View in EDS HTML Full Text PDF Full Text

Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images.

Saved in:
Bibliographic Details
Title: Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images.
Authors: Whitwell, J. L., Boeve, B. F., Weigand, S. D., Senjem, M. L., Gunter, J. L., Baker, M. C., DeJesus ‐ Hernandez, M., Knopman, D. S., Wszolek, Z. K., Petersen, R. C., Rademakers, R., Jack, C. R., Josephs, K. A.
Source: European Journal of Neurology. May2015, Vol. 22 Issue 5, p745-752. 8p.
Subjects: Cerebral atrophy, Magnetic resonance imaging, Brain imaging, Biomarkers, Longitudinal method, Genetic mutation, Temporal lobe
Abstract: Background and purpose The aim of our study was to determine the utility of longitudinal magnetic resonance imaging ( MRI) measurements as potential biomarkers in the main genetic variants of frontotemporal dementia ( FTD), including microtubule-associated protein tau ( MAPT) and progranulin ( GRN) mutations and C9 ORF72 repeat expansions, as well as sporadic FTD. Methods In this longitudinal study, 58 subjects were identified who had at least two MRI and MAPT mutations ( n = 21), GRN mutations ( n = 11), C9 ORF72 repeat expansions ( n = 11) or sporadic FTD ( n = 15). A total of 198 serial MRI measurements were analyzed. Rates of whole brain atrophy were calculated using the boundary shift integral. Regional rates of atrophy were calculated using tensor-based morphometry. Sample size estimates were calculated. Results Progressive brain atrophy was observed in all groups, with fastest rates of whole brain atrophy in GRN, followed by sporadic FTD, C9 ORF72 and MAPT. All variants showed greatest rates in the frontal and temporal lobes, with parietal lobes also strikingly affected in GRN. Regional rates of atrophy across all lobes were greater in GRN compared to the other groups. C9 ORF72 showed greater rates of atrophy in the left cerebellum and right occipital lobe than MAPT, and sporadic FTD showed greater rates in the anterior cingulate than C9 ORF72 and MAPT. Sample size estimates were lowest using temporal lobe rates in GRN, ventricular rates in MAPT and C9 ORF72, and whole brain rates in sporadic FTD. Conclusion These data support the utility of using rates of atrophy as outcome measures in future drug trials in FTD and show that different imaging biomarkers may offer advantages in the different variants of FTD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 101947095
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Whitwell%2C+J%2E+L%2E%22">Whitwell, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Boeve%2C+B%2E+F%2E%22">Boeve, B. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Weigand%2C+S%2E+D%2E%22">Weigand, S. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Senjem%2C+M%2E+L%2E%22">Senjem, M. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Gunter%2C+J%2E+L%2E%22">Gunter, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Baker%2C+M%2E+C%2E%22">Baker, M. C.</searchLink><br /><searchLink fieldCode="AR" term="%22DeJesus+‐+Hernandez%2C+M%2E%22">DeJesus ‐ Hernandez, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Knopman%2C+D%2E+S%2E%22">Knopman, D. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Wszolek%2C+Z%2E+K%2E%22">Wszolek, Z. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Petersen%2C+R%2E+C%2E%22">Petersen, R. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Rademakers%2C+R%2E%22">Rademakers, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Jack%2C+C%2E+R%2E%22">Jack, C. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Josephs%2C+K%2E+A%2E%22">Josephs, K. A.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. May2015, Vol. 22 Issue 5, p745-752. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cerebral+atrophy%22">Cerebral atrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose The aim of our study was to determine the utility of longitudinal magnetic resonance imaging ( MRI) measurements as potential biomarkers in the main genetic variants of frontotemporal dementia ( FTD), including microtubule-associated protein tau ( MAPT) and progranulin ( GRN) mutations and C9 ORF72 repeat expansions, as well as sporadic FTD. Methods In this longitudinal study, 58 subjects were identified who had at least two MRI and MAPT mutations ( n = 21), GRN mutations ( n = 11), C9 ORF72 repeat expansions ( n = 11) or sporadic FTD ( n = 15). A total of 198 serial MRI measurements were analyzed. Rates of whole brain atrophy were calculated using the boundary shift integral. Regional rates of atrophy were calculated using tensor-based morphometry. Sample size estimates were calculated. Results Progressive brain atrophy was observed in all groups, with fastest rates of whole brain atrophy in GRN, followed by sporadic FTD, C9 ORF72 and MAPT. All variants showed greatest rates in the frontal and temporal lobes, with parietal lobes also strikingly affected in GRN. Regional rates of atrophy across all lobes were greater in GRN compared to the other groups. C9 ORF72 showed greater rates of atrophy in the left cerebellum and right occipital lobe than MAPT, and sporadic FTD showed greater rates in the anterior cingulate than C9 ORF72 and MAPT. Sample size estimates were lowest using temporal lobe rates in GRN, ventricular rates in MAPT and C9 ORF72, and whole brain rates in sporadic FTD. Conclusion These data support the utility of using rates of atrophy as outcome measures in future drug trials in FTD and show that different imaging biomarkers may offer advantages in the different variants of FTD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=101947095
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.12675
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 745
    Subjects:
      – SubjectFull: Cerebral atrophy
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Brain imaging
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Genetic mutation
        Type: general
      – SubjectFull: Temporal lobe
        Type: general
    Titles:
      – TitleFull: Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Whitwell, J. L.
      – PersonEntity:
          Name:
            NameFull: Boeve, B. F.
      – PersonEntity:
          Name:
            NameFull: Weigand, S. D.
      – PersonEntity:
          Name:
            NameFull: Senjem, M. L.
      – PersonEntity:
          Name:
            NameFull: Gunter, J. L.
      – PersonEntity:
          Name:
            NameFull: Baker, M. C.
      – PersonEntity:
          Name:
            NameFull: DeJesus ‐ Hernandez, M.
      – PersonEntity:
          Name:
            NameFull: Knopman, D. S.
      – PersonEntity:
          Name:
            NameFull: Wszolek, Z. K.
      – PersonEntity:
          Name:
            NameFull: Petersen, R. C.
      – PersonEntity:
          Name:
            NameFull: Rademakers, R.
      – PersonEntity:
          Name:
            NameFull: Jack, C. R.
      – PersonEntity:
          Name:
            NameFull: Josephs, K. A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 22
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1