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The chorda tympani degenerates during chronic otitis media: an electron microscopy study.

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Title: The chorda tympani degenerates during chronic otitis media: an electron microscopy study.
Authors: Berling, Katarina (AUTHOR), Mannström, Paula (AUTHOR), Ulfendahl, Mats (AUTHOR), Danckwardt Lillieström, Niklas (AUTHOR), von Unge, Magnus (AUTHOR)
Source: Acta Oto-Laryngologica. Jun2015, Vol. 135 Issue 6, p542-548. 7p.
Subjects: Confidence intervals, Ear surgery, Electron microscopy, Neurodegeneration, Otitis media, Research funding, Taste disorders, Tympanic membrane, Data analysis software, Descriptive statistics, Odds ratio
Abstract: Conclusion: Chorda tympani nerve specimens from ears with chronic inflammatory middle ear disease exhibit structural signs of degeneration. These correlate well with taste disturbance. Simultaneously, they exhibit signs of regeneration, which may explain the ability for taste recovery. Objectives: The chorda tympani, the major taste nerve, runs uncovered through the middle ear cavity. This situation exposes it to various forms of middle ear pathology. A difference has been noticed regarding taste symptoms pre- and postoperatively between inflammatory and non-inflammatory diseases. The present study aimed to investigate ultrastructural changes of chorda tympani in different forms of inflammatory middle ear disease, such as chronic suppurative otitis media and cholesteatoma, as compared with normal. Methods: Five chorda tympani specimens were collected from healthy middle ears of patients subjected to surgery for acoustic neuroma, to be used as normal controls, and five from middle ears with chronic otitis media or cholesteatoma, where the nerve could not be saved during the operation. Light and electron microscopy were performed. Results: For all five nerves from diseased ears, microscopy showed a higher percentage of axon and myelin sheath degeneration than in the normal controls. Furthermore, three of the five also exhibited sprouting. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: The chorda tympani degenerates during chronic otitis media: an electron microscopy study.
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  Data: <searchLink fieldCode="AR" term="%22Berling%2C+Katarina%22">Berling, Katarina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mannström%2C+Paula%22">Mannström, Paula</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ulfendahl%2C+Mats%22">Ulfendahl, Mats</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Danckwardt+Lillieström%2C+Niklas%22">Danckwardt Lillieström, Niklas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22von+Unge%2C+Magnus%22">von Unge, Magnus</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jun2015, Vol. 135 Issue 6, p542-548. 7p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Ear+surgery%22">Ear surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Electron+microscopy%22">Electron microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Otitis+media%22">Otitis media</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Taste+disorders%22">Taste disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Tympanic+membrane%22">Tympanic membrane</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusion: Chorda tympani nerve specimens from ears with chronic inflammatory middle ear disease exhibit structural signs of degeneration. These correlate well with taste disturbance. Simultaneously, they exhibit signs of regeneration, which may explain the ability for taste recovery. Objectives: The chorda tympani, the major taste nerve, runs uncovered through the middle ear cavity. This situation exposes it to various forms of middle ear pathology. A difference has been noticed regarding taste symptoms pre- and postoperatively between inflammatory and non-inflammatory diseases. The present study aimed to investigate ultrastructural changes of chorda tympani in different forms of inflammatory middle ear disease, such as chronic suppurative otitis media and cholesteatoma, as compared with normal. Methods: Five chorda tympani specimens were collected from healthy middle ears of patients subjected to surgery for acoustic neuroma, to be used as normal controls, and five from middle ears with chronic otitis media or cholesteatoma, where the nerve could not be saved during the operation. Light and electron microscopy were performed. Results: For all five nerves from diseased ears, microscopy showed a higher percentage of axon and myelin sheath degeneration than in the normal controls. Furthermore, three of the five also exhibited sprouting. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3109/00016489.2014.999875
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 542
    Subjects:
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Ear surgery
        Type: general
      – SubjectFull: Electron microscopy
        Type: general
      – SubjectFull: Neurodegeneration
        Type: general
      – SubjectFull: Otitis media
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Taste disorders
        Type: general
      – SubjectFull: Tympanic membrane
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Odds ratio
        Type: general
    Titles:
      – TitleFull: The chorda tympani degenerates during chronic otitis media: an electron microscopy study.
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            NameFull: Berling, Katarina
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            NameFull: Mannström, Paula
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            NameFull: Ulfendahl, Mats
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            NameFull: Danckwardt Lillieström, Niklas
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            NameFull: von Unge, Magnus
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            – D: 01
              M: 06
              Text: Jun2015
              Type: published
              Y: 2015
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              Value: 135
            – Type: issue
              Value: 6
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            – TitleFull: Acta Oto-Laryngologica
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