View in EDS

Effect of celecoxib on restenosis after coronary angioplasty with a Taxus stent (COREA-TAXUS trial): an open-label randomised controlled study.

Saved in:
Bibliographic Details
Title: Effect of celecoxib on restenosis after coronary angioplasty with a Taxus stent (COREA-TAXUS trial): an open-label randomised controlled study.
Authors: Koo BK (AUTHOR), Kim YS (AUTHOR), Park KW (AUTHOR), Yang HM (AUTHOR), Kwon DA (AUTHOR), Chung JW (AUTHOR), Hahn JY (AUTHOR), Lee HY (AUTHOR), Park JS (AUTHOR), Kang HJ (AUTHOR), Cho YS (AUTHOR), Youn TJ (AUTHOR), Chung WY (AUTHOR), Chae IH (AUTHOR), Choi DJ (AUTHOR), Oh BH (AUTHOR), Park YB (AUTHOR), Kim HS (AUTHOR)
Source: Lancet. 8/18/2007, Vol. 370 Issue 9587, p567-574. 8p.
Abstract: BACKGROUND: In-vitro and animal experiments have shown that the cyclo-oxygenase 2 inhibitor celecoxib can reduce formation of neointima within stents. We aimed to test whether celecoxib has similar effects in a clinical setting. METHODS: In a randomised two-centre trial, we enrolled 274 patients who had angina pectoris or a positive stress test and who had native coronary artery lesions for which implantation of paclitaxel-eluting stents was feasible. All patients were given aspirin (100 mg daily) and clopidogrel (75 mg daily). 136 patients were randomly assigned to receive celecoxib (400 mg before the intervention, and 200 mg twice daily for 6 months after the procedure). The primary endpoint was late luminal loss on quantitative coronary angiography at 6 months after the intervention. Secondary endpoints were cardiac death, non-fatal myocardial infarction, and revascularisation of the target lesion. Analysis was done on a modified intention-to-treat basis. This study is registered with ClinicalTrials.gov, number NCT00292721. FINDINGS: At 6 months, mean in-stent late luminal loss was lower in the celecoxib group (0.49 mm, SD 0.47) than in the control group (0.75 mm, 0.60) (absolute difference 0.26 mm; 95% CI 0.12-0.40). Frequency of secondary outcomes at 6 months was also lower in the celecoxib group, mainly because of a reduced need for revascularisation of the target lesion. INTERPRETATION: These data suggest that the adjunctive use of celecoxib for 6 months after stent implantation in patients with coronary artery disease is safe and can reduce the need for revascularisation of the target lesion. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 105642805
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of celecoxib on restenosis after coronary angioplasty with a Taxus stent (COREA-TAXUS trial): an open-label randomised controlled study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Koo+BK%22">Koo BK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim+YS%22">Kim YS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+KW%22">Park KW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang+HM%22">Yang HM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon+DA%22">Kwon DA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung+JW%22">Chung JW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hahn+JY%22">Hahn JY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee+HY%22">Lee HY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+JS%22">Park JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang+HJ%22">Kang HJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cho+YS%22">Cho YS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Youn+TJ%22">Youn TJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung+WY%22">Chung WY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chae+IH%22">Chae IH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi+DJ%22">Choi DJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oh+BH%22">Oh BH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+YB%22">Park YB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim+HS%22">Kim HS</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 8/18/2007, Vol. 370 Issue 9587, p567-574. 8p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: In-vitro and animal experiments have shown that the cyclo-oxygenase 2 inhibitor celecoxib can reduce formation of neointima within stents. We aimed to test whether celecoxib has similar effects in a clinical setting. METHODS: In a randomised two-centre trial, we enrolled 274 patients who had angina pectoris or a positive stress test and who had native coronary artery lesions for which implantation of paclitaxel-eluting stents was feasible. All patients were given aspirin (100 mg daily) and clopidogrel (75 mg daily). 136 patients were randomly assigned to receive celecoxib (400 mg before the intervention, and 200 mg twice daily for 6 months after the procedure). The primary endpoint was late luminal loss on quantitative coronary angiography at 6 months after the intervention. Secondary endpoints were cardiac death, non-fatal myocardial infarction, and revascularisation of the target lesion. Analysis was done on a modified intention-to-treat basis. This study is registered with ClinicalTrials.gov, number NCT00292721. FINDINGS: At 6 months, mean in-stent late luminal loss was lower in the celecoxib group (0.49 mm, SD 0.47) than in the control group (0.75 mm, 0.60) (absolute difference 0.26 mm; 95% CI 0.12-0.40). Frequency of secondary outcomes at 6 months was also lower in the celecoxib group, mainly because of a reduced need for revascularisation of the target lesion. INTERPRETATION: These data suggest that the adjunctive use of celecoxib for 6 months after stent implantation in patients with coronary artery disease is safe and can reduce the need for revascularisation of the target lesion. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105642805
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/s0140-6736(07)61295-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 567
    Titles:
      – TitleFull: Effect of celecoxib on restenosis after coronary angioplasty with a Taxus stent (COREA-TAXUS trial): an open-label randomised controlled study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Koo BK
      – PersonEntity:
          Name:
            NameFull: Kim YS
      – PersonEntity:
          Name:
            NameFull: Park KW
      – PersonEntity:
          Name:
            NameFull: Yang HM
      – PersonEntity:
          Name:
            NameFull: Kwon DA
      – PersonEntity:
          Name:
            NameFull: Chung JW
      – PersonEntity:
          Name:
            NameFull: Hahn JY
      – PersonEntity:
          Name:
            NameFull: Lee HY
      – PersonEntity:
          Name:
            NameFull: Park JS
      – PersonEntity:
          Name:
            NameFull: Kang HJ
      – PersonEntity:
          Name:
            NameFull: Cho YS
      – PersonEntity:
          Name:
            NameFull: Youn TJ
      – PersonEntity:
          Name:
            NameFull: Chung WY
      – PersonEntity:
          Name:
            NameFull: Chae IH
      – PersonEntity:
          Name:
            NameFull: Choi DJ
      – PersonEntity:
          Name:
            NameFull: Oh BH
      – PersonEntity:
          Name:
            NameFull: Park YB
      – PersonEntity:
          Name:
            NameFull: Kim HS
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 18
              M: 08
              Text: 8/18/2007
              Type: published
              Y: 2007
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 370
            – Type: issue
              Value: 9587
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1