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Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis.

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Title: Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis.
Authors: Marrazzo JM (AUTHOR), Cook RL (AUTHOR), Wiesenfeld HC (AUTHOR), Murray PJ (AUTHOR), Busse B (AUTHOR), Krohn M (AUTHOR), Hillier SL (AUTHOR)
Source: Journal of Women's Health (15409996). Nov2006, Vol. 15 Issue 9, p1053-1060. 8p.
Subjects: Vaginal diseases, Bacterial disease treatment, Patient satisfaction, Women patients, Lactobacillus, Hydrogen peroxide, Pharmaceutical encapsulation, Placebos, Medical care
Abstract: Objective: To assess women's satisfaction with a vaginal capsule containing human-derived, H[2]O[2]-producing Lactobacillus crispatus at completion of a randomized, placebo-controlled study for treatment of bacterial vaginosis (BV). Methods: Women aged 14-35 years with BV were randomized to Lactobacillus or placebo intravaginal capsule twice daily for 3 days monthly for 3 months. Attitudes were assessed with a standardized scale at the final follow-up visit, and associations of satisfaction with clinical and gram stain cure of BV were determined. Results: Four hundred twenty-four women were randomized at enrollment, and 232 (55%) provided data on satisfaction at the final visit. Overall, satisfaction with the capsule was high and was independent of subjects' race, age, and prior history of BV. Report of satisfaction with the capsule, belief that it contained healthy bacteria, and belief that its use improved vaginal health were directly related to clinical cure and to improved Nugent score. Except for women who had BV at the final follow-up visit, most subjects believed that the capsule contained healthy bacteria independent of any outcome reflecting cure. Willingness to use the capsule again was not significantly related to whether subjects experienced clinical cure or normalization of Nugent score at either visit. Adverse effects were rare and were largely related to a perceived difference in vaginal discharge. Conclusions: Satisfaction with an intravaginal capsule and positive beliefs about its use for BV treatment were prevalent, especially among women with a clinical and microbiological response to BV therapy. However, most women expressed willingness to use the product again regardless of clinical response. Acceptability of and interest in alternative BV treatments, such as L. crispatus intravaginal applications, are high. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis.
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  Data: <searchLink fieldCode="AR" term="%22Marrazzo+JM%22">Marrazzo JM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cook+RL%22">Cook RL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiesenfeld+HC%22">Wiesenfeld HC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Murray+PJ%22">Murray PJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Busse+B%22">Busse B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krohn+M%22">Krohn M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hillier+SL%22">Hillier SL</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Women's+Health+%2815409996%29%22">Journal of Women's Health (15409996)</searchLink>. Nov2006, Vol. 15 Issue 9, p1053-1060. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Vaginal+diseases%22">Vaginal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+disease+treatment%22">Bacterial disease treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+satisfaction%22">Patient satisfaction</searchLink><br /><searchLink fieldCode="DE" term="%22Women+patients%22">Women patients</searchLink><br /><searchLink fieldCode="DE" term="%22Lactobacillus%22">Lactobacillus</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen+peroxide%22">Hydrogen peroxide</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+encapsulation%22">Pharmaceutical encapsulation</searchLink><br /><searchLink fieldCode="DE" term="%22Placebos%22">Placebos</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care%22">Medical care</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To assess women's satisfaction with a vaginal capsule containing human-derived, H[2]O[2]-producing Lactobacillus crispatus at completion of a randomized, placebo-controlled study for treatment of bacterial vaginosis (BV). Methods: Women aged 14-35 years with BV were randomized to Lactobacillus or placebo intravaginal capsule twice daily for 3 days monthly for 3 months. Attitudes were assessed with a standardized scale at the final follow-up visit, and associations of satisfaction with clinical and gram stain cure of BV were determined. Results: Four hundred twenty-four women were randomized at enrollment, and 232 (55%) provided data on satisfaction at the final visit. Overall, satisfaction with the capsule was high and was independent of subjects' race, age, and prior history of BV. Report of satisfaction with the capsule, belief that it contained healthy bacteria, and belief that its use improved vaginal health were directly related to clinical cure and to improved Nugent score. Except for women who had BV at the final follow-up visit, most subjects believed that the capsule contained healthy bacteria independent of any outcome reflecting cure. Willingness to use the capsule again was not significantly related to whether subjects experienced clinical cure or normalization of Nugent score at either visit. Adverse effects were rare and were largely related to a perceived difference in vaginal discharge. Conclusions: Satisfaction with an intravaginal capsule and positive beliefs about its use for BV treatment were prevalent, especially among women with a clinical and microbiological response to BV therapy. However, most women expressed willingness to use the product again regardless of clinical response. Acceptability of and interest in alternative BV treatments, such as L. crispatus intravaginal applications, are high. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105843296
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        Value: 10.1089/jwh.2006.15.1053
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        Text: English
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      – SubjectFull: Vaginal diseases
        Type: general
      – SubjectFull: Bacterial disease treatment
        Type: general
      – SubjectFull: Patient satisfaction
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      – SubjectFull: Women patients
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      – SubjectFull: Lactobacillus
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      – SubjectFull: Hydrogen peroxide
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      – SubjectFull: Pharmaceutical encapsulation
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      – SubjectFull: Placebos
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      – SubjectFull: Medical care
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      – TitleFull: Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis.
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              Text: Nov2006
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