Alzheimer's disease.
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| Title: | Alzheimer's disease. |
|---|---|
| Authors: | Blennow K (AUTHOR), de Leon MJ (AUTHOR), Zetterberg H (AUTHOR), Blennow, Kaj (AUTHOR), de Leon, Mony J (AUTHOR), Zetterberg, Henrik (AUTHOR) |
| Source: | Lancet. 7/29/2006, Vol. 368 Issue 9533, p387-403. 17p. |
| Abstract: | Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease--ie, plaques, composed of amyloid beta (Abeta), and tangles, composed of hyperphosphorylated tau. However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's disease is a very rare autosomal dominant disease with early onset, caused by mutations in the amyloid precursor protein and presenilin genes, both linked to Abeta metabolism. By contrast with familial disease, sporadic Alzheimer's disease is very common with more than 15 million people affected worldwide. The cause of the sporadic form of the disease is unknown, probably because the disease is heterogeneous, caused by ageing in concert with a complex interaction of both genetic and environmental risk factors. This seminar reviews the key aspects of the disease, including epidemiology, genetics, pathogenesis, diagnosis, and treatment, as well as recent developments and controversies. [ABSTRACT FROM AUTHOR] |
| Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106003161 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Alzheimer's disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Blennow+K%22">Blennow K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Leon+MJ%22">de Leon MJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zetterberg+H%22">Zetterberg H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blennow%2C+Kaj%22">Blennow, Kaj</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Leon%2C+Mony+J%22">de Leon, Mony J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zetterberg%2C+Henrik%22">Zetterberg, Henrik</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 7/29/2006, Vol. 368 Issue 9533, p387-403. 17p. – Name: Abstract Label: Abstract Group: Ab Data: Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease--ie, plaques, composed of amyloid beta (Abeta), and tangles, composed of hyperphosphorylated tau. However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's disease is a very rare autosomal dominant disease with early onset, caused by mutations in the amyloid precursor protein and presenilin genes, both linked to Abeta metabolism. By contrast with familial disease, sporadic Alzheimer's disease is very common with more than 15 million people affected worldwide. The cause of the sporadic form of the disease is unknown, probably because the disease is heterogeneous, caused by ageing in concert with a complex interaction of both genetic and environmental risk factors. This seminar reviews the key aspects of the disease, including epidemiology, genetics, pathogenesis, diagnosis, and treatment, as well as recent developments and controversies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106003161 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/s0140-6736(06)69113-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 387 Titles: – TitleFull: Alzheimer's disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Blennow K – PersonEntity: Name: NameFull: de Leon MJ – PersonEntity: Name: NameFull: Zetterberg H – PersonEntity: Name: NameFull: Blennow, Kaj – PersonEntity: Name: NameFull: de Leon, Mony J – PersonEntity: Name: NameFull: Zetterberg, Henrik IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 07 Text: 7/29/2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 368 – Type: issue Value: 9533 Titles: – TitleFull: Lancet Type: main |
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