Effects of the menstrual cycle on mood, neurocognitive and neuroendocrine function in healthy premenopausal women.
Saved in:
| Title: | Effects of the menstrual cycle on mood, neurocognitive and neuroendocrine function in healthy premenopausal women. |
|---|---|
| Authors: | Symonds CS (AUTHOR), Gallagher P (AUTHOR), Thompson JM (AUTHOR), Young AH (AUTHOR) |
| Source: | Psychological Medicine. Jan2004, Vol. 34 Issue 1, p93-102. 10p. |
| Abstract: | BACKGROUND: Neurocognitive functioning may be impaired in the luteal phase of the menstrual cycle due to associated changes in hypothalamic-pituitary adrenal (HPA) axis function. This study examines the relationship between changes in neurocognition and HPA axis function in different phases of the menstrual cycle. METHOD: Fifteen female volunteers, free from psychiatric history and hormonal medication were tested twice, during mid-follicular and late-luteal phases in a randomized, crossover design. Mood, neurocognitive function, and basal cortisol and dehydroepiandrosterone (DHEA) were profiled. RESULTS: Relative to the follicular phase, verbal fluency was impaired in the luteal phase and reaction times speeded on a continuous performance task, without affecting overall accuracy. 'Hedonic' scores on the UWIST-MACL scale were decreased in the luteal phase. There was also evidence of changes in the function of the HPA axis, with 24 h urinary cortisol concentrations and salivary DHEA levels being significantly lower during the luteal phase. CONCLUSIONS: These data suggest that luteal phase HPA axis function is lower than in the follicular phase in premenopausal healthy women. This putative biological difference may be important for our understanding of the aetiopathogenesis of menstrually related mood change and neurocognitive disturbance. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106004682 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Effects of the menstrual cycle on mood, neurocognitive and neuroendocrine function in healthy premenopausal women. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Symonds+CS%22">Symonds CS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gallagher+P%22">Gallagher P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thompson+JM%22">Thompson JM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Young+AH%22">Young AH</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jan2004, Vol. 34 Issue 1, p93-102. 10p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Neurocognitive functioning may be impaired in the luteal phase of the menstrual cycle due to associated changes in hypothalamic-pituitary adrenal (HPA) axis function. This study examines the relationship between changes in neurocognition and HPA axis function in different phases of the menstrual cycle. METHOD: Fifteen female volunteers, free from psychiatric history and hormonal medication were tested twice, during mid-follicular and late-luteal phases in a randomized, crossover design. Mood, neurocognitive function, and basal cortisol and dehydroepiandrosterone (DHEA) were profiled. RESULTS: Relative to the follicular phase, verbal fluency was impaired in the luteal phase and reaction times speeded on a continuous performance task, without affecting overall accuracy. 'Hedonic' scores on the UWIST-MACL scale were decreased in the luteal phase. There was also evidence of changes in the function of the HPA axis, with 24 h urinary cortisol concentrations and salivary DHEA levels being significantly lower during the luteal phase. CONCLUSIONS: These data suggest that luteal phase HPA axis function is lower than in the follicular phase in premenopausal healthy women. This putative biological difference may be important for our understanding of the aetiopathogenesis of menstrually related mood change and neurocognitive disturbance. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106004682 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/s0033291703008535 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 93 Titles: – TitleFull: Effects of the menstrual cycle on mood, neurocognitive and neuroendocrine function in healthy premenopausal women. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Symonds CS – PersonEntity: Name: NameFull: Gallagher P – PersonEntity: Name: NameFull: Thompson JM – PersonEntity: Name: NameFull: Young AH IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 34 – Type: issue Value: 1 Titles: – TitleFull: Psychological Medicine Type: main |
| ResultId | 1 |
