Strategy implementation in obsessive-compulsive disorder and trichotillomania.
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| Title: | Strategy implementation in obsessive-compulsive disorder and trichotillomania. |
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| Authors: | Chamberlain SR (AUTHOR), Blackwell AD (AUTHOR), Fineberg NA (AUTHOR), Robbins TW (AUTHOR), Sahakian BJ (AUTHOR) |
| Source: | Psychological Medicine. Jan2006, Vol. 36 Issue 1, p91-97. 7p. |
| Abstract: | Background. The use of strategies to aid performance when undertaking neuropsychological tasks is dependent on intact fronto-striatal circuitry, and growing evidence suggests impaired spontaneous use of strategies in patients with obsessive-compulsive disorder (OCD). However, studies to date have not examined the effects of strategy training on task performance in OCD or in trichotillomania (compulsive hair-pulling, a condition that has been argued to share overlap with OCD in terms of phenomenology and co-morbidity).Method. The ability to generate novel visuospatial sequences using a computer interface was examined before and after undertaking optimal strategy training in 20 OCD patients, 17 trichotillomania patients, and 20 controls (matched for age, education, and IQ).Results. OCD patients failed to improve ability to generate novel sequences above baseline despite successfully completing strategy training to the same extent as other groups. In contrast, performance of trichotillomania patients improved significantly after training to the same extent as controls. Groups did not differ on memory span, trial-by-trial action monitoring, or ability to generate novel visuospatial sequences prior to strategy training.Conclusions. Strategy implementation deficits, suggestive of cognitive inflexibility and fronto-striatal dysfunction, appear integral to the neurocognitive profile of OCD but not trichotillomania. Future research should investigate cognitive flexibility in obsessive-compulsive spectrum disorders using a variety of paradigms, and clarify the contribution of specific neural structures and transmitter systems to deficits reported. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106398264 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Strategy implementation in obsessive-compulsive disorder and trichotillomania. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chamberlain+SR%22">Chamberlain SR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blackwell+AD%22">Blackwell AD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fineberg+NA%22">Fineberg NA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robbins+TW%22">Robbins TW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sahakian+BJ%22">Sahakian BJ</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jan2006, Vol. 36 Issue 1, p91-97. 7p. – Name: Abstract Label: Abstract Group: Ab Data: Background. The use of strategies to aid performance when undertaking neuropsychological tasks is dependent on intact fronto-striatal circuitry, and growing evidence suggests impaired spontaneous use of strategies in patients with obsessive-compulsive disorder (OCD). However, studies to date have not examined the effects of strategy training on task performance in OCD or in trichotillomania (compulsive hair-pulling, a condition that has been argued to share overlap with OCD in terms of phenomenology and co-morbidity).Method. The ability to generate novel visuospatial sequences using a computer interface was examined before and after undertaking optimal strategy training in 20 OCD patients, 17 trichotillomania patients, and 20 controls (matched for age, education, and IQ).Results. OCD patients failed to improve ability to generate novel sequences above baseline despite successfully completing strategy training to the same extent as other groups. In contrast, performance of trichotillomania patients improved significantly after training to the same extent as controls. Groups did not differ on memory span, trial-by-trial action monitoring, or ability to generate novel visuospatial sequences prior to strategy training.Conclusions. Strategy implementation deficits, suggestive of cognitive inflexibility and fronto-striatal dysfunction, appear integral to the neurocognitive profile of OCD but not trichotillomania. Future research should investigate cognitive flexibility in obsessive-compulsive spectrum disorders using a variety of paradigms, and clarify the contribution of specific neural structures and transmitter systems to deficits reported. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/s0033291705006124 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 91 Titles: – TitleFull: Strategy implementation in obsessive-compulsive disorder and trichotillomania. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chamberlain SR – PersonEntity: Name: NameFull: Blackwell AD – PersonEntity: Name: NameFull: Fineberg NA – PersonEntity: Name: NameFull: Robbins TW – PersonEntity: Name: NameFull: Sahakian BJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 36 – Type: issue Value: 1 Titles: – TitleFull: Psychological Medicine Type: main |
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