Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome [corrected] [published erratum appears in PEDIATRICS 2006 Jun;117(6):2334].
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| Title: | Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome [corrected] [published erratum appears in PEDIATRICS 2006 Jun;117(6):2334]. |
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| Authors: | Gastiasoro-Cuesta E (AUTHOR), Alvarez-Diaz FJ (AUTHOR), Rey-Santano C (AUTHOR), Arnaiz-Renedo A (AUTHOR), Loureiro-Gonzalez B (AUTHOR), Valls-i-Soler A (AUTHOR) |
| Source: | Pediatrics. Feb2006, Vol. 117 Issue 2, p295-303. 9p. |
| Abstract: | BACKGROUND: Animal-derived, protein-containing surfactants seem to be superior to protein-free surfactants. Lucinactant, a synthetic surfactant containing a surfactant protein-B peptide analog, has been shown to be effective in animal models and phase II clinical trials. To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model. OBJECTIVE: The objective was to compare the acute and sustained effects of lucinactant among premature lambs with respiratory distress syndrome (RDS) with the effects of a natural porcine surfactant (poractant-alpha). METHODS: After 5 minutes of mechanical ventilation twin premature lambs were assigned randomly to the lucinactant group (30 mg/mL, 5.8 mL/kg) or the poractant-alpha group (80 mg/mL, 2.2 mL/kg). Heart rate, systemic arterial pressure, arterial pH, blood gas values, and lung mechanics were recorded for 12 hours. RESULTS: Baseline fetal pH values were similar for the 2 groups (pH 7.27). After 5 minutes of mechanical ventilation, severe RDS developed (pH: <7.08; Paco2: >80 mm Hg; Pao2: <40 mm Hg; dynamic compliance: <0.08 mL/cm H2O per kg). After surfactant instillation, similar improvements in gas exchange and lung mechanics were observed for the lucinactant and poractant-alpha groups at 1 hour (pH: 7.3 +/- 0.1 vs 7.4 +/- 0.1; Paco2: 8 +/- 18 mm Hg vs 40 +/- 8 mm Hg; Pao2: 167 +/- 52 mm Hg vs 259 +/- 51 mm Hg; dynamic compliance: 0.3 +/- 0.1 mL/cm H2O per kg vs 0.3 +/- 0.1 mL/cm H2O per kg). The improvements in lung function were sustained, with no differences between groups. Cardiovascular profiles remained stable in both groups. CONCLUSIONS: Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106434815 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome [corrected] [published erratum appears in PEDIATRICS 2006 Jun;117(6):2334]. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gastiasoro-Cuesta+E%22">Gastiasoro-Cuesta E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alvarez-Diaz+FJ%22">Alvarez-Diaz FJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rey-Santano+C%22">Rey-Santano C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arnaiz-Renedo+A%22">Arnaiz-Renedo A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Loureiro-Gonzalez+B%22">Loureiro-Gonzalez B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valls-i-Soler+A%22">Valls-i-Soler A</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Feb2006, Vol. 117 Issue 2, p295-303. 9p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Animal-derived, protein-containing surfactants seem to be superior to protein-free surfactants. Lucinactant, a synthetic surfactant containing a surfactant protein-B peptide analog, has been shown to be effective in animal models and phase II clinical trials. To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model. OBJECTIVE: The objective was to compare the acute and sustained effects of lucinactant among premature lambs with respiratory distress syndrome (RDS) with the effects of a natural porcine surfactant (poractant-alpha). METHODS: After 5 minutes of mechanical ventilation twin premature lambs were assigned randomly to the lucinactant group (30 mg/mL, 5.8 mL/kg) or the poractant-alpha group (80 mg/mL, 2.2 mL/kg). Heart rate, systemic arterial pressure, arterial pH, blood gas values, and lung mechanics were recorded for 12 hours. RESULTS: Baseline fetal pH values were similar for the 2 groups (pH 7.27). After 5 minutes of mechanical ventilation, severe RDS developed (pH: <7.08; Paco2: >80 mm Hg; Pao2: <40 mm Hg; dynamic compliance: <0.08 mL/cm H2O per kg). After surfactant instillation, similar improvements in gas exchange and lung mechanics were observed for the lucinactant and poractant-alpha groups at 1 hour (pH: 7.3 +/- 0.1 vs 7.4 +/- 0.1; Paco2: 8 +/- 18 mm Hg vs 40 +/- 8 mm Hg; Pao2: 167 +/- 52 mm Hg vs 259 +/- 51 mm Hg; dynamic compliance: 0.3 +/- 0.1 mL/cm H2O per kg vs 0.3 +/- 0.1 mL/cm H2O per kg). The improvements in lung function were sustained, with no differences between groups. Cardiovascular profiles remained stable in both groups. CONCLUSIONS: Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2005-0378 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 295 Titles: – TitleFull: Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome [corrected] [published erratum appears in PEDIATRICS 2006 Jun;117(6):2334]. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gastiasoro-Cuesta E – PersonEntity: Name: NameFull: Alvarez-Diaz FJ – PersonEntity: Name: NameFull: Rey-Santano C – PersonEntity: Name: NameFull: Arnaiz-Renedo A – PersonEntity: Name: NameFull: Loureiro-Gonzalez B – PersonEntity: Name: NameFull: Valls-i-Soler A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 117 – Type: issue Value: 2 Titles: – TitleFull: Pediatrics Type: main |
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