Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa.
Saved in:
| Title: | Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa. |
|---|---|
| Authors: | Fowler L (AUTHOR), Blackwell A (AUTHOR), Jaffa A (AUTHOR), Palmer R (AUTHOR), Robbins TW (AUTHOR), Sahakian BJ (AUTHOR), Dowson JH (AUTHOR) |
| Source: | Psychological Medicine. Apr2006, Vol. 36 Issue 4, p517-527. 11p. |
| Abstract: | BACKGROUND: Although many studies have reported impairments of neurocognitive performance in patients with anorexia nervosa (AN), these have involved a wide range of assessment methods and some findings are inconsistent. METHOD: Twenty-five female in-patients with a DSM-IV diagnosis of AN, identified from three units specializing in the treatment of eating disorders, volunteered for the study. Twenty-five non-clinical control subjects were recruited, matched for age, gender and estimated IQ. Subjects were assessed with a range of computer-administered neurocognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), which has been validated in many studies of neuropsychiatric disorders. RESULTS: The patient group showed significant but moderate impairments (i.e. less than one standard deviation below the mean performance of the control group) on tests of spatial recognition memory, a planning task and rapid visual information processing, while a subgroup of patients (n = 14) showed greater degrees of impairments on at least one of these tests. The degrees of impairments did not correlate with body mass index (BMI). No impairments were observed on tests of spatial span, pattern recognition memory, spatial working memory, matching-to-sample, paired associates learning and set-shifting. CONCLUSIONS: The findings, in relation to a mean BMI of 15.3, are compatible with, in general, subtle impairments in neurocognition in AN. However, in those patients with relatively severe degrees of impairments, these may have adverse effects on complex tasks of social and occupational functioning. Further research is needed on the nature of relevant causal mechanisms, including the effects of potentially confounding variables. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106443163 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fowler+L%22">Fowler L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blackwell+A%22">Blackwell A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jaffa+A%22">Jaffa A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palmer+R%22">Palmer R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robbins+TW%22">Robbins TW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sahakian+BJ%22">Sahakian BJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dowson+JH%22">Dowson JH</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Apr2006, Vol. 36 Issue 4, p517-527. 11p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Although many studies have reported impairments of neurocognitive performance in patients with anorexia nervosa (AN), these have involved a wide range of assessment methods and some findings are inconsistent. METHOD: Twenty-five female in-patients with a DSM-IV diagnosis of AN, identified from three units specializing in the treatment of eating disorders, volunteered for the study. Twenty-five non-clinical control subjects were recruited, matched for age, gender and estimated IQ. Subjects were assessed with a range of computer-administered neurocognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), which has been validated in many studies of neuropsychiatric disorders. RESULTS: The patient group showed significant but moderate impairments (i.e. less than one standard deviation below the mean performance of the control group) on tests of spatial recognition memory, a planning task and rapid visual information processing, while a subgroup of patients (n = 14) showed greater degrees of impairments on at least one of these tests. The degrees of impairments did not correlate with body mass index (BMI). No impairments were observed on tests of spatial span, pattern recognition memory, spatial working memory, matching-to-sample, paired associates learning and set-shifting. CONCLUSIONS: The findings, in relation to a mean BMI of 15.3, are compatible with, in general, subtle impairments in neurocognition in AN. However, in those patients with relatively severe degrees of impairments, these may have adverse effects on complex tasks of social and occupational functioning. Further research is needed on the nature of relevant causal mechanisms, including the effects of potentially confounding variables. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106443163 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/s0033291705006379 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 517 Titles: – TitleFull: Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fowler L – PersonEntity: Name: NameFull: Blackwell A – PersonEntity: Name: NameFull: Jaffa A – PersonEntity: Name: NameFull: Palmer R – PersonEntity: Name: NameFull: Robbins TW – PersonEntity: Name: NameFull: Sahakian BJ – PersonEntity: Name: NameFull: Dowson JH IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 36 – Type: issue Value: 4 Titles: – TitleFull: Psychological Medicine Type: main |
| ResultId | 1 |
