Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study.
Saved in:
| Title: | Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study. |
|---|---|
| Authors: | Little MP (AUTHOR), Breitling LP (AUTHOR), Basáñez M (AUTHOR), Alley ES (AUTHOR), Boatin BA (AUTHOR), Little, M P (AUTHOR), Breitling, L P (AUTHOR), Basáñez, M-G (AUTHOR), Alley, E S (AUTHOR), Boatin, B A (AUTHOR) |
| Source: | Lancet. 5/8/2004, Vol. 363 Issue 9420, p1514-1521. 8p. |
| Abstract: | |
| Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106569217 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Little+MP%22">Little MP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Breitling+LP%22">Breitling LP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Basáñez+M%22">Basáñez M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alley+ES%22">Alley ES</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boatin+BA%22">Boatin BA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Little%2C+M+P%22">Little, M P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Breitling%2C+L+P%22">Breitling, L P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Basáñez%2C+M-G%22">Basáñez, M-G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alley%2C+E+S%22">Alley, E S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boatin%2C+B+A%22">Boatin, B A</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 5/8/2004, Vol. 363 Issue 9420, p1514-1521. 8p. – Name: Abstract Label: Abstract Group: Ab Data: <bold>Background: </bold>Infection with the parasitic filarial nematode Onchocerca volvulus can lead to severe visual impairment and ultimately blindness. Excess mortality has been noted among people with onchocerciasis, but it is not clear whether this effect is entirely due to blindness, or mediated by some more direct effects of the infection. <bold>Methods: </bold>We assessed the relations between infection with O volvulus, visual acuity, and host mortality with data obtained by the Onchocerciasis Control Programme in West Africa from 2315 villages in 11 countries. <bold>Findings: </bold>297,756 people were eligible for follow-up, and accumulated 2,579449 person-years of follow-up from 1971 through 2001. 24,517 people died during this period; 1283 (5.2%) of these deaths were due to onchocerciasis. Mortality of the human host was significantly and positively associated with increasing microfilarial burden (p<0.00001), but not with blindness after adjustment for microfilarial load and other variables. Overall, after adjustment for microfilarial load and other variables, female individuals had a risk of death about 7.5% lower than males (p<0.00001). Rates of mortality peaked in the mid 1980s but generally decreased thereafter. <bold>Interpretation: </bold>We have shown a direct relation between O volvulus microfilarial load and host mortality in a comprehensive dataset and in both sexes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106569217 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/s0140-6736(04)16151-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1514 Titles: – TitleFull: Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Little MP – PersonEntity: Name: NameFull: Breitling LP – PersonEntity: Name: NameFull: Basáñez M – PersonEntity: Name: NameFull: Alley ES – PersonEntity: Name: NameFull: Boatin BA – PersonEntity: Name: NameFull: Little, M P – PersonEntity: Name: NameFull: Breitling, L P – PersonEntity: Name: NameFull: Basáñez, M-G – PersonEntity: Name: NameFull: Alley, E S – PersonEntity: Name: NameFull: Boatin, B A IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 05 Text: 5/8/2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 363 – Type: issue Value: 9420 Titles: – TitleFull: Lancet Type: main |
| ResultId | 1 |
