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Parental glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants.

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Title: Parental glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants.
Authors: Poindexter BB (AUTHOR), Ehrenkranz RA (AUTHOR), Stoll BJ (AUTHOR), Wright LL (AUTHOR), Poole WK (AUTHOR), Oh W (AUTHOR), Bauer CR (AUTHOR), Papile L (AUTHOR), Tyson JE (AUTHOR), Carlo WA (AUTHOR), Laptook AR (AUTHOR), Narendran V (AUTHOR), Stevenson DK (AUTHOR), Fanaroff AA (AUTHOR), Korones SB (AUTHOR), Shankaran S (AUTHOR), Finer NN (AUTHOR), Lemons JA (AUTHOR), National Institute of Child Health and Human Development Neonatal Research Network (CORPORATE AUTHOR)
Source: Pediatrics. May2004, Vol. 113 Issue 5, p1209-1215. 7p.
Abstract: BACKGROUND: Glutamine is one of the most abundant amino acids in both plasma and human milk, yet it is not included in standard intravenous amino acid solutions. Previous studies have suggested that parenteral nutrition (PN) supplemented with glutamine may reduce sepsis and mortality in critically ill adults. Whether glutamine supplementation would provide a similar benefit to extremely low birth weight (ELBW) infants is not known. METHODS: We performed a multicenter, randomized, double-masked, clinical trial to assess the safety and efficacy of early PN supplemented with glutamine in decreasing the risk of death or late-onset sepsis in ELBW infants. Infants 401 to 1000 g were randomized within 72 hours of birth to receive either TrophAmine (control) or an isonitrogenous study amino acid solution with 20% glutamine whenever they received PN up to 120 days of age, death, or discharge from the hospital. The primary outcome was death or late-onset sepsis. RESULTS: Of the 721 infants who were assigned to glutamine supplementation, 370 (51%) died or developed late-onset sepsis, as compared with 343 of the 712 infants (48%) assigned to control (relative risk: 1.07; 95% confidence interval: 0.97-1.17). Glutamine had no effect on tolerance of enteral feeds, necrotizing enterocolitis, or growth. No significant adverse events were observed with glutamine supplementation. CONCLUSIONS: Parenteral glutamine supplementation as studied did not decrease mortality or the incidence of late-onset sepsis in ELBW infants. Consequently, although no harm was demonstrated, routine use of parenteral glutamine supplementation cannot be recommended in this population. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Parental glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants.
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  Data: <searchLink fieldCode="AR" term="%22Poindexter+BB%22">Poindexter BB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ehrenkranz+RA%22">Ehrenkranz RA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stoll+BJ%22">Stoll BJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wright+LL%22">Wright LL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poole+WK%22">Poole WK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oh+W%22">Oh W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bauer+CR%22">Bauer CR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papile+L%22">Papile L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tyson+JE%22">Tyson JE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carlo+WA%22">Carlo WA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Laptook+AR%22">Laptook AR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Narendran+V%22">Narendran V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stevenson+DK%22">Stevenson DK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fanaroff+AA%22">Fanaroff AA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korones+SB%22">Korones SB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shankaran+S%22">Shankaran S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Finer+NN%22">Finer NN</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lemons+JA%22">Lemons JA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22National+Institute+of+Child+Health+and+Human+Development+Neonatal+Research+Network%22">National Institute of Child Health and Human Development Neonatal Research Network</searchLink> (CORPORATE AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. May2004, Vol. 113 Issue 5, p1209-1215. 7p.
– Name: Abstract
  Label: Abstract
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  Data: BACKGROUND: Glutamine is one of the most abundant amino acids in both plasma and human milk, yet it is not included in standard intravenous amino acid solutions. Previous studies have suggested that parenteral nutrition (PN) supplemented with glutamine may reduce sepsis and mortality in critically ill adults. Whether glutamine supplementation would provide a similar benefit to extremely low birth weight (ELBW) infants is not known. METHODS: We performed a multicenter, randomized, double-masked, clinical trial to assess the safety and efficacy of early PN supplemented with glutamine in decreasing the risk of death or late-onset sepsis in ELBW infants. Infants 401 to 1000 g were randomized within 72 hours of birth to receive either TrophAmine (control) or an isonitrogenous study amino acid solution with 20% glutamine whenever they received PN up to 120 days of age, death, or discharge from the hospital. The primary outcome was death or late-onset sepsis. RESULTS: Of the 721 infants who were assigned to glutamine supplementation, 370 (51%) died or developed late-onset sepsis, as compared with 343 of the 712 infants (48%) assigned to control (relative risk: 1.07; 95% confidence interval: 0.97-1.17). Glutamine had no effect on tolerance of enteral feeds, necrotizing enterocolitis, or growth. No significant adverse events were observed with glutamine supplementation. CONCLUSIONS: Parenteral glutamine supplementation as studied did not decrease mortality or the incidence of late-onset sepsis in ELBW infants. Consequently, although no harm was demonstrated, routine use of parenteral glutamine supplementation cannot be recommended in this population. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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