A new complication of stem cell transplantation: measles inclusion body encephalitis.
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| Title: | A new complication of stem cell transplantation: measles inclusion body encephalitis. |
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| Authors: | Freeman AF (AUTHOR), Jacobsohn DA (AUTHOR), Shulman ST (AUTHOR), Bellini WJ (AUTHOR), Jaggi P (AUTHOR), de Leon G (AUTHOR), Keating GF (AUTHOR), Kim F (AUTHOR), Pachman LM (AUTHOR), Kletzel M (AUTHOR), Duerst RE (AUTHOR) |
| Source: | Pediatrics. 2004 Nov Supplement, Vol. 114 Issue 5, pe657-60. 1p. |
| Abstract: | Measles inclusion body encephalitis (MIBE) is a disease of the immunocompromised host and typically occurs within 1 year of acute measles infection or vaccination. We report a 13-year-old boy who had chronic granulomatous disease and presented 38 days after stem cell transplantation with afebrile focal seizures that progressed despite multiple anticonvulsants. After an extensive diagnostic evaluation, brain biopsy was performed, revealing numerous intranuclear inclusion bodies consistent with paramyxovirus nucleocapsids. Measles studies including reverse transcriptase-polymerase chain reaction and viral growth confirmed measles virus, genotype D3. Immunohistochemistry was positive for measles nucleoprotein. Despite intravenous ribavirin therapy, the patient died. MIBE has not been described in stem cell recipients but is a disease of immunocompromised hosts and typically occurs within 1 year of measles infection, exposure, or vaccination. Our case is unusual as neither the patient nor the stem cell donor had apparent recent measles exposure or vaccination, and neither had recent travel to measles-endemic regions. The patient had an erythematous rash several weeks before the neurologic symptoms; however, skin biopsy was consistent with graft-versus-host disease, and immunohistochemistry studies for measles nucleoprotein were negative. As measles genotype D3 has not been seen in areas where the child lived since his early childhood, the possibility of an unusually long latency period between initial measles infection and MIBE is raised. In addition, this case demonstrates the utility of brain biopsy in the diagnosis of encephalitis of unknown cause in the immunocompromised host. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106627494 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A new complication of stem cell transplantation: measles inclusion body encephalitis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Freeman+AF%22">Freeman AF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jacobsohn+DA%22">Jacobsohn DA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shulman+ST%22">Shulman ST</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bellini+WJ%22">Bellini WJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jaggi+P%22">Jaggi P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Leon+G%22">de Leon G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Keating+GF%22">Keating GF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim+F%22">Kim F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pachman+LM%22">Pachman LM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kletzel+M%22">Kletzel M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duerst+RE%22">Duerst RE</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. 2004 Nov Supplement, Vol. 114 Issue 5, pe657-60. 1p. – Name: Abstract Label: Abstract Group: Ab Data: Measles inclusion body encephalitis (MIBE) is a disease of the immunocompromised host and typically occurs within 1 year of acute measles infection or vaccination. We report a 13-year-old boy who had chronic granulomatous disease and presented 38 days after stem cell transplantation with afebrile focal seizures that progressed despite multiple anticonvulsants. After an extensive diagnostic evaluation, brain biopsy was performed, revealing numerous intranuclear inclusion bodies consistent with paramyxovirus nucleocapsids. Measles studies including reverse transcriptase-polymerase chain reaction and viral growth confirmed measles virus, genotype D3. Immunohistochemistry was positive for measles nucleoprotein. Despite intravenous ribavirin therapy, the patient died. MIBE has not been described in stem cell recipients but is a disease of immunocompromised hosts and typically occurs within 1 year of measles infection, exposure, or vaccination. Our case is unusual as neither the patient nor the stem cell donor had apparent recent measles exposure or vaccination, and neither had recent travel to measles-endemic regions. The patient had an erythematous rash several weeks before the neurologic symptoms; however, skin biopsy was consistent with graft-versus-host disease, and immunohistochemistry studies for measles nucleoprotein were negative. As measles genotype D3 has not been seen in areas where the child lived since his early childhood, the possibility of an unusually long latency period between initial measles infection and MIBE is raised. In addition, this case demonstrates the utility of brain biopsy in the diagnosis of encephalitis of unknown cause in the immunocompromised host. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2004-0949 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e657 Titles: – TitleFull: A new complication of stem cell transplantation: measles inclusion body encephalitis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Freeman AF – PersonEntity: Name: NameFull: Jacobsohn DA – PersonEntity: Name: NameFull: Shulman ST – PersonEntity: Name: NameFull: Bellini WJ – PersonEntity: Name: NameFull: Jaggi P – PersonEntity: Name: NameFull: de Leon G – PersonEntity: Name: NameFull: Keating GF – PersonEntity: Name: NameFull: Kim F – PersonEntity: Name: NameFull: Pachman LM – PersonEntity: Name: NameFull: Kletzel M – PersonEntity: Name: NameFull: Duerst RE IsPartOfRelationships: – BibEntity: Dates: – D: 04 M: 11 Text: 2004 Nov Supplement Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 114 – Type: issue Value: 5 Titles: – TitleFull: Pediatrics Type: main |
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