View in EDS HTML Full Text PDF Full Text

Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning.

Saved in:
Bibliographic Details
Title: Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning.
Authors: Weiss R (AUTHOR), Dufour S (AUTHOR), Taksali SE (AUTHOR), Tamborlane WV (AUTHOR), Petersen KF (AUTHOR), Bonadonna RC (AUTHOR), Boselli L (AUTHOR), Barbetta G (AUTHOR), Allen K (AUTHOR), Rife F (AUTHOR), Savoye M (AUTHOR), Dziura J (AUTHOR), Sherwin R (AUTHOR), Shulman GI (AUTHOR), Caprio S (AUTHOR), Weiss, Ram (AUTHOR), Dufour, Sylvie (AUTHOR), Taksali, Sara E (AUTHOR), Tamborlane, William V (AUTHOR), Petersen, Kitt F (AUTHOR)
Source: Lancet. 9/20/2003, Vol. 362 Issue 9388, p951-957. 7p.
Abstract: Background: Impaired glucose tolerance is common among obese adolescents, but the changes in insulin sensitivity and secretion that lead to this prediabetic state are unknown. We investigated whether altered partitioning of myocellular and abdominal fat relates to abnormalities in glucose homoeostasis in obese adolescents with prediabetes.Methods: We studied 14 obese children with impaired glucose tolerance and 14 with normal glucose tolerance, of similar ages, sex distribution, and degree of obesity. Insulin sensitivity and secretion were assessed by the euglycaemic-hyperinsulinaemic clamp and the hyperglycaemic clamp. Intramyocellular lipid was assessed by proton nuclear magnetic resonance spectroscopy and abdominal fat distribution by magnetic resonance imaging.Findings: Peripheral glucose disposal was significantly lower in individuals with impaired than in those with normal glucose tolerance (mean 35.4 [SE 4.0] vs 60.6 [7.2] micromoles per kg lean body mass per min; p=0.023) owing to a reduction in non-oxidative glucose disposal metabolism (storage). Individuals with impaired glucose tolerance had higher intramyocellular lipid content (3.04 [0.43] vs 1.99 [0.19]%, p=0.03), lower abdominal subcutaneous fat (460 [47] vs 626 [39] cm2, p=0.04), and slightly higher visceral fat than the controls (70 [11] vs 47 [6] cm2, p=0.065), resulting in a higher ratio of visceral to subcutaneous fat (0.15 [0.02] vs 0.07 [0.01], p=0.002). Intramyocellular and visceral lipid contents were inversely related to the glucose disposal and non-oxidative glucose metabolism and positively related to the 2 h plasma glucose concentration.Interpretation: In obese children and adolescents with prediabetes, intramyocellular and intra-abdominal lipid accumulation is closely linked to the development of severe peripheral insulin resistance. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 106768125
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Weiss+R%22">Weiss R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dufour+S%22">Dufour S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taksali+SE%22">Taksali SE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tamborlane+WV%22">Tamborlane WV</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Petersen+KF%22">Petersen KF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bonadonna+RC%22">Bonadonna RC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boselli+L%22">Boselli L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barbetta+G%22">Barbetta G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Allen+K%22">Allen K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rife+F%22">Rife F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Savoye+M%22">Savoye M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dziura+J%22">Dziura J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sherwin+R%22">Sherwin R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shulman+GI%22">Shulman GI</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caprio+S%22">Caprio S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weiss%2C+Ram%22">Weiss, Ram</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dufour%2C+Sylvie%22">Dufour, Sylvie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taksali%2C+Sara+E%22">Taksali, Sara E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tamborlane%2C+William+V%22">Tamborlane, William V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Petersen%2C+Kitt+F%22">Petersen, Kitt F</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 9/20/2003, Vol. 362 Issue 9388, p951-957. 7p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>Impaired glucose tolerance is common among obese adolescents, but the changes in insulin sensitivity and secretion that lead to this prediabetic state are unknown. We investigated whether altered partitioning of myocellular and abdominal fat relates to abnormalities in glucose homoeostasis in obese adolescents with prediabetes.<bold>Methods: </bold>We studied 14 obese children with impaired glucose tolerance and 14 with normal glucose tolerance, of similar ages, sex distribution, and degree of obesity. Insulin sensitivity and secretion were assessed by the euglycaemic-hyperinsulinaemic clamp and the hyperglycaemic clamp. Intramyocellular lipid was assessed by proton nuclear magnetic resonance spectroscopy and abdominal fat distribution by magnetic resonance imaging.<bold>Findings: </bold>Peripheral glucose disposal was significantly lower in individuals with impaired than in those with normal glucose tolerance (mean 35.4 [SE 4.0] vs 60.6 [7.2] micromoles per kg lean body mass per min; p=0.023) owing to a reduction in non-oxidative glucose disposal metabolism (storage). Individuals with impaired glucose tolerance had higher intramyocellular lipid content (3.04 [0.43] vs 1.99 [0.19]%, p=0.03), lower abdominal subcutaneous fat (460 [47] vs 626 [39] cm2, p=0.04), and slightly higher visceral fat than the controls (70 [11] vs 47 [6] cm2, p=0.065), resulting in a higher ratio of visceral to subcutaneous fat (0.15 [0.02] vs 0.07 [0.01], p=0.002). Intramyocellular and visceral lipid contents were inversely related to the glucose disposal and non-oxidative glucose metabolism and positively related to the 2 h plasma glucose concentration.<bold>Interpretation: </bold>In obese children and adolescents with prediabetes, intramyocellular and intra-abdominal lipid accumulation is closely linked to the development of severe peripheral insulin resistance. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106768125
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/s0140-6736(03)14364-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 951
    Titles:
      – TitleFull: Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Weiss R
      – PersonEntity:
          Name:
            NameFull: Dufour S
      – PersonEntity:
          Name:
            NameFull: Taksali SE
      – PersonEntity:
          Name:
            NameFull: Tamborlane WV
      – PersonEntity:
          Name:
            NameFull: Petersen KF
      – PersonEntity:
          Name:
            NameFull: Bonadonna RC
      – PersonEntity:
          Name:
            NameFull: Boselli L
      – PersonEntity:
          Name:
            NameFull: Barbetta G
      – PersonEntity:
          Name:
            NameFull: Allen K
      – PersonEntity:
          Name:
            NameFull: Rife F
      – PersonEntity:
          Name:
            NameFull: Savoye M
      – PersonEntity:
          Name:
            NameFull: Dziura J
      – PersonEntity:
          Name:
            NameFull: Sherwin R
      – PersonEntity:
          Name:
            NameFull: Shulman GI
      – PersonEntity:
          Name:
            NameFull: Caprio S
      – PersonEntity:
          Name:
            NameFull: Weiss, Ram
      – PersonEntity:
          Name:
            NameFull: Dufour, Sylvie
      – PersonEntity:
          Name:
            NameFull: Taksali, Sara E
      – PersonEntity:
          Name:
            NameFull: Tamborlane, William V
      – PersonEntity:
          Name:
            NameFull: Petersen, Kitt F
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 20
              M: 09
              Text: 9/20/2003
              Type: published
              Y: 2003
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 362
            – Type: issue
              Value: 9388
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1