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Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study.

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Title: Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study.
Authors: Oomen CM (AUTHOR), Ocké MC (AUTHOR), Feskens EJM (AUTHOR), van Erp-Baart MJ (AUTHOR), Kok FJ (AUTHOR), Kromhout D (AUTHOR), Oomen, C M (AUTHOR), Ocké, M C (AUTHOR), Feskens, E J (AUTHOR), van Erp-Baart, M A (AUTHOR), Kok, F J (AUTHOR), Kromhout, D (AUTHOR)
Source: Lancet. 3/10/2001, Vol. 357 Issue 9258, p746-751. 6p.
Abstract: Background: Evidence on the relation between trans fatty acid intake and coronary heart disease is limited. We investigated this relation in a Dutch population with a fairly high trans fatty acid intake, including trans fatty acids from partly hydrogenated fish oils.Methods: We prospectively studied 667 men of the Zutphen Elderly Study aged 64-84 years and free of coronary heart disease at baseline. We used dietary surveys to establish the participants' food consumption patterns. Information on risk factors and diet was obtained in 1985, 1990, and 1995. After 10 years of follow-up from 1985-95, there were 98 cases of fatal or non-fatal coronary heart disease.Findings: Between 1985 and 1995, average trans fatty acid intake decreased from 4.3% to 1.9% of energy. After adjustment for age, body mass index, smoking, and dietary covariates, trans fatty acid intake at baseline was positively associated with the 10-year risk of coronary heart disease. The relative risk for a difference of 2% of energy in trans fatty acid intake at baseline was 1.28 (95% CI 1.01-1.61).Interpretation: A high intake of trans fatty acids (all types of isomers) contributes to the risk of coronary heart disease. The substantial decrease in trans fatty acid intake, mainly due to industrial lowering of trans contents in Dutch edible fats, could therefore have had a large public-health impact. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study.
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  Data: <searchLink fieldCode="AR" term="%22Oomen+CM%22">Oomen CM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ocké+MC%22">Ocké MC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feskens+EJM%22">Feskens EJM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Erp-Baart+MJ%22">van Erp-Baart MJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kok+FJ%22">Kok FJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kromhout+D%22">Kromhout D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oomen%2C+C+M%22">Oomen, C M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ocké%2C+M+C%22">Ocké, M C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feskens%2C+E+J%22">Feskens, E J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Erp-Baart%2C+M+A%22">van Erp-Baart, M A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kok%2C+F+J%22">Kok, F J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kromhout%2C+D%22">Kromhout, D</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/10/2001, Vol. 357 Issue 9258, p746-751. 6p.
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  Data: <bold>Background: </bold>Evidence on the relation between trans fatty acid intake and coronary heart disease is limited. We investigated this relation in a Dutch population with a fairly high trans fatty acid intake, including trans fatty acids from partly hydrogenated fish oils.<bold>Methods: </bold>We prospectively studied 667 men of the Zutphen Elderly Study aged 64-84 years and free of coronary heart disease at baseline. We used dietary surveys to establish the participants' food consumption patterns. Information on risk factors and diet was obtained in 1985, 1990, and 1995. After 10 years of follow-up from 1985-95, there were 98 cases of fatal or non-fatal coronary heart disease.<bold>Findings: </bold>Between 1985 and 1995, average trans fatty acid intake decreased from 4.3% to 1.9% of energy. After adjustment for age, body mass index, smoking, and dietary covariates, trans fatty acid intake at baseline was positively associated with the 10-year risk of coronary heart disease. The relative risk for a difference of 2% of energy in trans fatty acid intake at baseline was 1.28 (95% CI 1.01-1.61).<bold>Interpretation: </bold>A high intake of trans fatty acids (all types of isomers) contributes to the risk of coronary heart disease. The substantial decrease in trans fatty acid intake, mainly due to industrial lowering of trans contents in Dutch edible fats, could therefore have had a large public-health impact. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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