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Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism.

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Title: Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism.
Authors: Oliveira, J., Debnath, M., Etain, B., Bennabi, M., Hamdani, N., Lajnef, M., Bengoufa, D., Fortier, C., Boukouaci, W., Bellivier, F., Kahn, J.‐P., Henry, C., Charron, D., Krishnamoorthy, R., Leboyer, M., Tamouza, R.
Source: Acta Psychiatrica Scandinavica. Sep2015, Vol. 132 Issue 3, p218-225. 8p. 4 Charts.
Subjects: Bipolar disorder, Nitric-oxide synthases, Genetic polymorphisms, Neural transmission, Psychology
Abstract: Objective Given the importance of nitric oxide system in oxidative stress, inflammation, neurotransmission and cerebrovascular tone regulation, we postulated its potential dysfunction in bipolar disorder ( BD) and suicide. By simultaneously analysing variants of three isoforms of nitric oxide synthase ( NOS) genes, we explored interindividual genetic liability to suicidal behaviour in BD. Method A total of 536 patients with BD ( DSM- IV) and 160 healthy controls were genotyped for functionally relevant NOS1, NOS2 and NOS3 polymorphisms. History of suicidal behaviour and violent suicide attempt was documented for 511 patients with BD. Chi-squared test was used to perform genetic association analyses and logistic regression to test for gene-gene interactions. Results NOS3 rs1799983 T homozygous state was associated with violent suicide attempts (26.4% vs. 10.8%, in patients and controls, P = 0.002, corrected P ( Pc) = 0.004, OR: 2.96, 95% CI = 1.33-6.34), and this association was restricted to the early-onset BD subgroup (37.9% vs. 10.8%, in early-onset BD and controls, P = 0.0003, Pc = 0.0006 OR: 5.05, 95% CI: 1.95-12.45), while we found no association with BD per se and no gene-gene interactions. Conclusion Our results bring further evidence for the potential involvement of endothelial NOS gene variants in susceptibility to suicidal behaviour. Future exploration of this pathway on larger cohort of suicidal behaviour is warranted. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism.
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  Data: <searchLink fieldCode="AR" term="%22Oliveira%2C+J%2E%22">Oliveira, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Debnath%2C+M%2E%22">Debnath, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Etain%2C+B%2E%22">Etain, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Bennabi%2C+M%2E%22">Bennabi, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hamdani%2C+N%2E%22">Hamdani, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Lajnef%2C+M%2E%22">Lajnef, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bengoufa%2C+D%2E%22">Bengoufa, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Fortier%2C+C%2E%22">Fortier, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Boukouaci%2C+W%2E%22">Boukouaci, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Bellivier%2C+F%2E%22">Bellivier, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kahn%2C+J%2E‐P%2E%22">Kahn, J.‐P.</searchLink><br /><searchLink fieldCode="AR" term="%22Henry%2C+C%2E%22">Henry, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Charron%2C+D%2E%22">Charron, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Krishnamoorthy%2C+R%2E%22">Krishnamoorthy, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Leboyer%2C+M%2E%22">Leboyer, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tamouza%2C+R%2E%22">Tamouza, R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Sep2015, Vol. 132 Issue 3, p218-225. 8p. 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Nitric-oxide+synthases%22">Nitric-oxide synthases</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology%22">Psychology</searchLink>
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  Data: Objective Given the importance of nitric oxide system in oxidative stress, inflammation, neurotransmission and cerebrovascular tone regulation, we postulated its potential dysfunction in bipolar disorder ( BD) and suicide. By simultaneously analysing variants of three isoforms of nitric oxide synthase ( NOS) genes, we explored interindividual genetic liability to suicidal behaviour in BD. Method A total of 536 patients with BD ( DSM- IV) and 160 healthy controls were genotyped for functionally relevant NOS1, NOS2 and NOS3 polymorphisms. History of suicidal behaviour and violent suicide attempt was documented for 511 patients with BD. Chi-squared test was used to perform genetic association analyses and logistic regression to test for gene-gene interactions. Results NOS3 rs1799983 T homozygous state was associated with violent suicide attempts (26.4% vs. 10.8%, in patients and controls, P = 0.002, corrected P ( Pc) = 0.004, OR: 2.96, 95% CI = 1.33-6.34), and this association was restricted to the early-onset BD subgroup (37.9% vs. 10.8%, in early-onset BD and controls, P = 0.0003, Pc = 0.0006 OR: 5.05, 95% CI: 1.95-12.45), while we found no association with BD per se and no gene-gene interactions. Conclusion Our results bring further evidence for the potential involvement of endothelial NOS gene variants in susceptibility to suicidal behaviour. Future exploration of this pathway on larger cohort of suicidal behaviour is warranted. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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