DNA Repair Capacity in Healthy Medical Students During and After Exam Stress.
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| Title: | DNA Repair Capacity in Healthy Medical Students During and After Exam Stress. |
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| Authors: | Cohen, Lorenzo, Marshall Jr., Gailen D., Lie Cheng, Gailen D., Agarwal, Sandeep K., Qingyi Wei |
| Source: | Journal of Behavioral Medicine. Dec2000, Vol. 23 Issue 6, p531-544. 14p. |
| Subjects: | DNA repair, Medical students, Psychological stress |
| Abstract: | There has been extensive research into the effects of stress on immune function but little on the effects of stress on DNA repair capacity (DRC), a process central to maintaining a normal cell cycle. Defective DRC is one of the factors responsible for carcinogenesis. In the present study we assessed DRC in healthy medical students during times of high and low stress. Sixteen medical students were evaluated during the third day of a 5-day exam period and then again 3 weeks later, after vacation. At both time points, participants underwent a brief physical examination, had venous blood drawn, and completed questionnaires to identify subjective stress levels. The DRC was assessed by the host-cell reaction assay, which measures nucleotide excision repair capacity. Participants reported significantly higher levels of subjective stress during the exam period than after vacation. DRC was also significantly higher during the exam period than after vacation, suggesting a positive association between subject stress levels and DRC. The results are discussed in relation to previous findings and implications for cancer research. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Behavioral Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11306913 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: DNA Repair Capacity in Healthy Medical Students During and After Exam Stress. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Cohen%2C+Lorenzo%22">Cohen, Lorenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Marshall+Jr%2E%2C+Gailen+D%2E%22">Marshall Jr., Gailen D.</searchLink><br /><searchLink fieldCode="AR" term="%22Lie+Cheng%2C+Gailen+D%2E%22">Lie Cheng, Gailen D.</searchLink><br /><searchLink fieldCode="AR" term="%22Agarwal%2C+Sandeep+K%2E%22">Agarwal, Sandeep K.</searchLink><br /><searchLink fieldCode="AR" term="%22Qingyi+Wei%22">Qingyi Wei</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Behavioral+Medicine%22">Journal of Behavioral Medicine</searchLink>. Dec2000, Vol. 23 Issue 6, p531-544. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22DNA+repair%22">DNA repair</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+students%22">Medical students</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: There has been extensive research into the effects of stress on immune function but little on the effects of stress on DNA repair capacity (DRC), a process central to maintaining a normal cell cycle. Defective DRC is one of the factors responsible for carcinogenesis. In the present study we assessed DRC in healthy medical students during times of high and low stress. Sixteen medical students were evaluated during the third day of a 5-day exam period and then again 3 weeks later, after vacation. At both time points, participants underwent a brief physical examination, had venous blood drawn, and completed questionnaires to identify subjective stress levels. The DRC was assessed by the host-cell reaction assay, which measures nucleotide excision repair capacity. Participants reported significantly higher levels of subjective stress during the exam period than after vacation. DRC was also significantly higher during the exam period than after vacation, suggesting a positive association between subject stress levels and DRC. The results are discussed in relation to previous findings and implications for cancer research. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Behavioral Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1023/A:1005503502992 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 531 Subjects: – SubjectFull: DNA repair Type: general – SubjectFull: Medical students Type: general – SubjectFull: Psychological stress Type: general Titles: – TitleFull: DNA Repair Capacity in Healthy Medical Students During and After Exam Stress. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cohen, Lorenzo – PersonEntity: Name: NameFull: Marshall Jr., Gailen D. – PersonEntity: Name: NameFull: Lie Cheng, Gailen D. – PersonEntity: Name: NameFull: Agarwal, Sandeep K. – PersonEntity: Name: NameFull: Qingyi Wei IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2000 Type: published Y: 2000 Identifiers: – Type: issn-print Value: 01607715 Numbering: – Type: volume Value: 23 – Type: issue Value: 6 Titles: – TitleFull: Journal of Behavioral Medicine Type: main |
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