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Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.

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Title: Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.
Authors: Marusak, Hilary, Kuruvadi, Nisha, Vila, Angela, Shattuck, David, Joshi, Shantanu, Joshi, Anand, Jella, Pavan, Thomason, Moriah
Source: European Child & Adolescent Psychiatry. May2016, Vol. 25 Issue 5, p509-518. 10p.
Subjects: Limbic system, Affective disorders, Chi-squared test, Genetic polymorphisms, Magnetic resonance imaging, T-test (Statistics), Wounds & injuries, Brain-derived neurotrophic factor, Mann Whitney U Test, Genotypes, Anatomy
Abstract: Childhood trauma is a major precipitating factor in psychiatric disease. Emerging data suggest that stress susceptibility is genetically determined, and that risk is mediated by changes in limbic brain circuitry. There is a need to identify markers of disease vulnerability, and it is critical that these markers be investigated in childhood and adolescence, a time when neural networks are particularly malleable and when psychiatric disorders frequently emerge. In this preliminary study, we evaluated whether a common variant in the brain-derived neurotrophic factor (BDNF) gene ( Val66Met; rs6265) interacts with childhood trauma to predict limbic gray matter volume in a sample of 55 youth high in sociodemographic risk. We found trauma-by-BDNF interactions in the right subcallosal area and right hippocampus, wherein BDNF-related gray matter changes were evident in youth without histories of trauma. In youth without trauma exposure, lower hippocampal volume was related to higher symptoms of anxiety. These data provide preliminary evidence for a contribution of a common BDNF gene variant to the neural correlates of childhood trauma among high-risk urban youth. Altered limbic structure in early life may lay the foundation for longer term patterns of neural dysfunction, and hold implications for understanding the psychiatric and psychobiological consequences of traumatic stress on the developing brain. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.
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  Data: <searchLink fieldCode="AR" term="%22Marusak%2C+Hilary%22">Marusak, Hilary</searchLink><br /><searchLink fieldCode="AR" term="%22Kuruvadi%2C+Nisha%22">Kuruvadi, Nisha</searchLink><br /><searchLink fieldCode="AR" term="%22Vila%2C+Angela%22">Vila, Angela</searchLink><br /><searchLink fieldCode="AR" term="%22Shattuck%2C+David%22">Shattuck, David</searchLink><br /><searchLink fieldCode="AR" term="%22Joshi%2C+Shantanu%22">Joshi, Shantanu</searchLink><br /><searchLink fieldCode="AR" term="%22Joshi%2C+Anand%22">Joshi, Anand</searchLink><br /><searchLink fieldCode="AR" term="%22Jella%2C+Pavan%22">Jella, Pavan</searchLink><br /><searchLink fieldCode="AR" term="%22Thomason%2C+Moriah%22">Thomason, Moriah</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. May2016, Vol. 25 Issue 5, p509-518. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Limbic+system%22">Limbic system</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Wounds+%26+injuries%22">Wounds & injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Anatomy%22">Anatomy</searchLink>
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  Data: Childhood trauma is a major precipitating factor in psychiatric disease. Emerging data suggest that stress susceptibility is genetically determined, and that risk is mediated by changes in limbic brain circuitry. There is a need to identify markers of disease vulnerability, and it is critical that these markers be investigated in childhood and adolescence, a time when neural networks are particularly malleable and when psychiatric disorders frequently emerge. In this preliminary study, we evaluated whether a common variant in the brain-derived neurotrophic factor (BDNF) gene ( Val66Met; rs6265) interacts with childhood trauma to predict limbic gray matter volume in a sample of 55 youth high in sociodemographic risk. We found trauma-by-BDNF interactions in the right subcallosal area and right hippocampus, wherein BDNF-related gray matter changes were evident in youth without histories of trauma. In youth without trauma exposure, lower hippocampal volume was related to higher symptoms of anxiety. These data provide preliminary evidence for a contribution of a common BDNF gene variant to the neural correlates of childhood trauma among high-risk urban youth. Altered limbic structure in early life may lay the foundation for longer term patterns of neural dysfunction, and hold implications for understanding the psychiatric and psychobiological consequences of traumatic stress on the developing brain. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00787-015-0759-4
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      – SubjectFull: Chi-squared test
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              Text: May2016
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