View in EDS PDF Full Text

Prognostic value of health-related quality of life in patients with metastatic pancreatic adenocarcinoma: a random forest methodology.

Saved in:
Bibliographic Details
Title: Prognostic value of health-related quality of life in patients with metastatic pancreatic adenocarcinoma: a random forest methodology.
Authors: Diouf, Momar, Filleron, Thomas, Pointet, Anne-Laure, Dupont-Gossard, Anne-Claire, Malka, David, Artru, Pascal, Gauthier, Mélanie, Lecomte, Thierry, Aparicio, Thomas, Thirot-Bidault, Anne, Lobry, Céline, Fein, Francine, Dubreuil, Olivier, Landi, Bruno, Zaanan, Aziz, Taieb, Julien, Bonnetain, Franck, Gauthier, Mélanie (AUTHOR), Lobry, Céline (AUTHOR)
Source: Quality of Life Research. Jul2016, Vol. 25 Issue 7, p1713-1723. 11p.
Subjects: Health status indicators, Cancer patients, Pancreatic cancer, Random forest algorithms, Adenocarcinoma, Oncology, Prognosis, Fatigue (Physiology), Quality of life, Mental health, Appetite, Clinical trials, Comparative studies, Research methodology, Medical cooperation, Pancreatic tumors, Questionnaires, Research, Self-evaluation, Self-perception, Evaluation research, Psychology
Abstract: Purpose: Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is currently an important parameter in the choice of treatment strategy for metastatic pancreatic adenocarcinoma (mPA) patients. However, previous research has shown that patients' self-reported health-related quality of life (HRQOL) scales provided additional prognostic information in homogeneous groups of patients with respect to ECOG-PS. The aim of this study was to identify HRQOL scales with independent prognostic value in mPA and to propose prognostic groups for these patients.Methods: We analysed data from 98 chemotherapy-naive patients with histologically proven mPA recruited from 2007 to 2011 in the FIRGEM phase II study which aimed to compare the effectiveness of two chemotherapy regimen. HRQOL data were assessed with the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire. A random survival forest methodology was used to impute missing data and to identify major prognostic factors for overall survival.Results: Baseline HRQOL assessment was completed by 60 % of patients (59/98). Twelve prognostic variables were identified. The three most important prognostic variables were fatigue, appetite loss, and role functioning, followed by three laboratory variables. The model's discriminative power assessed by Harrell's C statistic was 0.65. Fatigue score explained almost all the survival variability.Conclusion: HRQOL scores have prognostic value for mPA patients with good ECOG-PS. Moreover, the patient's fatigue, appetite loss, and self-perception of daily activities were more reliable prognostic indicators than clinical and laboratory variables. These HRQOL scores, especially the fatigue symptom, should be urgently included for prognostic assessment of mPA patients (with good ECOG-PS). [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 115900111
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Prognostic value of health-related quality of life in patients with metastatic pancreatic adenocarcinoma: a random forest methodology.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Diouf%2C+Momar%22">Diouf, Momar</searchLink><br /><searchLink fieldCode="AR" term="%22Filleron%2C+Thomas%22">Filleron, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Pointet%2C+Anne-Laure%22">Pointet, Anne-Laure</searchLink><br /><searchLink fieldCode="AR" term="%22Dupont-Gossard%2C+Anne-Claire%22">Dupont-Gossard, Anne-Claire</searchLink><br /><searchLink fieldCode="AR" term="%22Malka%2C+David%22">Malka, David</searchLink><br /><searchLink fieldCode="AR" term="%22Artru%2C+Pascal%22">Artru, Pascal</searchLink><br /><searchLink fieldCode="AR" term="%22Gauthier%2C+Mélanie%22">Gauthier, Mélanie</searchLink><br /><searchLink fieldCode="AR" term="%22Lecomte%2C+Thierry%22">Lecomte, Thierry</searchLink><br /><searchLink fieldCode="AR" term="%22Aparicio%2C+Thomas%22">Aparicio, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Thirot-Bidault%2C+Anne%22">Thirot-Bidault, Anne</searchLink><br /><searchLink fieldCode="AR" term="%22Lobry%2C+Céline%22">Lobry, Céline</searchLink><br /><searchLink fieldCode="AR" term="%22Fein%2C+Francine%22">Fein, Francine</searchLink><br /><searchLink fieldCode="AR" term="%22Dubreuil%2C+Olivier%22">Dubreuil, Olivier</searchLink><br /><searchLink fieldCode="AR" term="%22Landi%2C+Bruno%22">Landi, Bruno</searchLink><br /><searchLink fieldCode="AR" term="%22Zaanan%2C+Aziz%22">Zaanan, Aziz</searchLink><br /><searchLink fieldCode="AR" term="%22Taieb%2C+Julien%22">Taieb, Julien</searchLink><br /><searchLink fieldCode="AR" term="%22Bonnetain%2C+Franck%22">Bonnetain, Franck</searchLink><br /><searchLink fieldCode="AR" term="%22Gauthier%2C+Mélanie%22">Gauthier, Mélanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lobry%2C+Céline%22">Lobry, Céline</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Jul2016, Vol. 25 Issue 7, p1713-1723. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Health+status+indicators%22">Health status indicators</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+cancer%22">Pancreatic cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Random+forest+algorithms%22">Random forest algorithms</searchLink><br /><searchLink fieldCode="DE" term="%22Adenocarcinoma%22">Adenocarcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Oncology%22">Oncology</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Fatigue+%28Physiology%29%22">Fatigue (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Appetite%22">Appetite</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+tumors%22">Pancreatic tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Self-evaluation%22">Self-evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Self-perception%22">Self-perception</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology%22">Psychology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Purpose: </bold>Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is currently an important parameter in the choice of treatment strategy for metastatic pancreatic adenocarcinoma (mPA) patients. However, previous research has shown that patients' self-reported health-related quality of life (HRQOL) scales provided additional prognostic information in homogeneous groups of patients with respect to ECOG-PS. The aim of this study was to identify HRQOL scales with independent prognostic value in mPA and to propose prognostic groups for these patients.<bold>Methods: </bold>We analysed data from 98 chemotherapy-naive patients with histologically proven mPA recruited from 2007 to 2011 in the FIRGEM phase II study which aimed to compare the effectiveness of two chemotherapy regimen. HRQOL data were assessed with the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire. A random survival forest methodology was used to impute missing data and to identify major prognostic factors for overall survival.<bold>Results: </bold>Baseline HRQOL assessment was completed by 60 % of patients (59/98). Twelve prognostic variables were identified. The three most important prognostic variables were fatigue, appetite loss, and role functioning, followed by three laboratory variables. The model's discriminative power assessed by Harrell's C statistic was 0.65. Fatigue score explained almost all the survival variability.<bold>Conclusion: </bold>HRQOL scores have prognostic value for mPA patients with good ECOG-PS. Moreover, the patient's fatigue, appetite loss, and self-perception of daily activities were more reliable prognostic indicators than clinical and laboratory variables. These HRQOL scores, especially the fatigue symptom, should be urgently included for prognostic assessment of mPA patients (with good ECOG-PS). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=115900111
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s11136-015-1198-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1713
    Subjects:
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Cancer patients
        Type: general
      – SubjectFull: Pancreatic cancer
        Type: general
      – SubjectFull: Random forest algorithms
        Type: general
      – SubjectFull: Adenocarcinoma
        Type: general
      – SubjectFull: Oncology
        Type: general
      – SubjectFull: Prognosis
        Type: general
      – SubjectFull: Fatigue (Physiology)
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Mental health
        Type: general
      – SubjectFull: Appetite
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Pancreatic tumors
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Self-evaluation
        Type: general
      – SubjectFull: Self-perception
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Psychology
        Type: general
    Titles:
      – TitleFull: Prognostic value of health-related quality of life in patients with metastatic pancreatic adenocarcinoma: a random forest methodology.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Diouf, Momar
      – PersonEntity:
          Name:
            NameFull: Filleron, Thomas
      – PersonEntity:
          Name:
            NameFull: Pointet, Anne-Laure
      – PersonEntity:
          Name:
            NameFull: Dupont-Gossard, Anne-Claire
      – PersonEntity:
          Name:
            NameFull: Malka, David
      – PersonEntity:
          Name:
            NameFull: Artru, Pascal
      – PersonEntity:
          Name:
            NameFull: Gauthier, Mélanie
      – PersonEntity:
          Name:
            NameFull: Lecomte, Thierry
      – PersonEntity:
          Name:
            NameFull: Aparicio, Thomas
      – PersonEntity:
          Name:
            NameFull: Thirot-Bidault, Anne
      – PersonEntity:
          Name:
            NameFull: Lobry, Céline
      – PersonEntity:
          Name:
            NameFull: Fein, Francine
      – PersonEntity:
          Name:
            NameFull: Dubreuil, Olivier
      – PersonEntity:
          Name:
            NameFull: Landi, Bruno
      – PersonEntity:
          Name:
            NameFull: Zaanan, Aziz
      – PersonEntity:
          Name:
            NameFull: Taieb, Julien
      – PersonEntity:
          Name:
            NameFull: Bonnetain, Franck
      – PersonEntity:
          Name:
            NameFull: Gauthier, Mélanie
      – PersonEntity:
          Name:
            NameFull: Lobry, Céline
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 09629343
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Quality of Life Research
              Type: main
ResultId 1