View in EDS PDF Full Text

Occurrence and long-term outcome of tumefactive demyelinating lesions in multiple sclerosis.

Saved in:
Bibliographic Details
Title: Occurrence and long-term outcome of tumefactive demyelinating lesions in multiple sclerosis.
Authors: Totaro, Rocco, Di Carmine, C., Splendiani, A., Torlone, S., Patriarca, L., Carrocci, C., Sciamanna, S., Marini, C., Carolei, A.
Source: Neurological Sciences. Jul2016, Vol. 37 Issue 7, p1113-1117. 5p. 2 Charts.
Subjects: Multiple sclerosis, Demyelination, Kaplan-Meier estimator, Progression-free survival, Cohort analysis, Disease progression, Prognosis, Functional assessment, Longitudinal method, Magnetic resonance imaging, Survival analysis (Biometry), Proportional hazards models, Disease complications
Abstract: Although tumefactive multiple sclerosis is a well recognized variant of multiple sclerosis, prognostic uncertainty still exists about long term prognosis. The aim of this study was to estimate the occurrence and long term outcome of tumefactive demyelinating lesions (TDLs) in a cohort of multiple sclerosis patients. We reviewed brain MRI of 443 patients referred to our MS clinic. All patients meeting the McDonald criteria for multiple sclerosis and showing at least one TDL were included. Kaplan-Meier estimates of disease-free survival in patient cohort were compared with control group without TDLs using a log-rank test. Seven cases with TDLs were identified (occurrence 1.58 %). Tumefactive demyelinating lesion recurrence was 16.6 %. Cumulative proportion of patients free from clinical relapse and from new T2 lesions was lower in the control group although not reaching statistical significance (30 vs 50 %; P = 0.666 and 21.7 vs 33.3 %; P = 0.761, respectively). Disability progression analysis showed a not significant trend towards lower probability of remaining progression free for TDL patients (50 vs 61 %; P = 0.295). Occurrence of tumefactive demyelinating lesions in our cohort was higher than those reported in other studies. Overall, TDLs were not predictive of poor outcome in terms of disability progression. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 116324315
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Occurrence and long-term outcome of tumefactive demyelinating lesions in multiple sclerosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Totaro%2C+Rocco%22">Totaro, Rocco</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Carmine%2C+C%2E%22">Di Carmine, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Splendiani%2C+A%2E%22">Splendiani, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Torlone%2C+S%2E%22">Torlone, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Patriarca%2C+L%2E%22">Patriarca, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Carrocci%2C+C%2E%22">Carrocci, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Sciamanna%2C+S%2E%22">Sciamanna, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Marini%2C+C%2E%22">Marini, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Carolei%2C+A%2E%22">Carolei, A.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jul2016, Vol. 37 Issue 7, p1113-1117. 5p. 2 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Demyelination%22">Demyelination</searchLink><br /><searchLink fieldCode="DE" term="%22Kaplan-Meier+estimator%22">Kaplan-Meier estimator</searchLink><br /><searchLink fieldCode="DE" term="%22Progression-free+survival%22">Progression-free survival</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+assessment%22">Functional assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Although tumefactive multiple sclerosis is a well recognized variant of multiple sclerosis, prognostic uncertainty still exists about long term prognosis. The aim of this study was to estimate the occurrence and long term outcome of tumefactive demyelinating lesions (TDLs) in a cohort of multiple sclerosis patients. We reviewed brain MRI of 443 patients referred to our MS clinic. All patients meeting the McDonald criteria for multiple sclerosis and showing at least one TDL were included. Kaplan-Meier estimates of disease-free survival in patient cohort were compared with control group without TDLs using a log-rank test. Seven cases with TDLs were identified (occurrence 1.58 %). Tumefactive demyelinating lesion recurrence was 16.6 %. Cumulative proportion of patients free from clinical relapse and from new T2 lesions was lower in the control group although not reaching statistical significance (30 vs 50 %; P = 0.666 and 21.7 vs 33.3 %; P = 0.761, respectively). Disability progression analysis showed a not significant trend towards lower probability of remaining progression free for TDL patients (50 vs 61 %; P = 0.295). Occurrence of tumefactive demyelinating lesions in our cohort was higher than those reported in other studies. Overall, TDLs were not predictive of poor outcome in terms of disability progression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=116324315
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-016-2558-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 1113
    Subjects:
      – SubjectFull: Multiple sclerosis
        Type: general
      – SubjectFull: Demyelination
        Type: general
      – SubjectFull: Kaplan-Meier estimator
        Type: general
      – SubjectFull: Progression-free survival
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
      – SubjectFull: Disease progression
        Type: general
      – SubjectFull: Prognosis
        Type: general
      – SubjectFull: Functional assessment
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Survival analysis (Biometry)
        Type: general
      – SubjectFull: Proportional hazards models
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: Occurrence and long-term outcome of tumefactive demyelinating lesions in multiple sclerosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Totaro, Rocco
      – PersonEntity:
          Name:
            NameFull: Di Carmine, C.
      – PersonEntity:
          Name:
            NameFull: Splendiani, A.
      – PersonEntity:
          Name:
            NameFull: Torlone, S.
      – PersonEntity:
          Name:
            NameFull: Patriarca, L.
      – PersonEntity:
          Name:
            NameFull: Carrocci, C.
      – PersonEntity:
          Name:
            NameFull: Sciamanna, S.
      – PersonEntity:
          Name:
            NameFull: Marini, C.
      – PersonEntity:
          Name:
            NameFull: Carolei, A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 37
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1