Long-term whole-body vibration training in two late-onset Pompe disease patients.
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| Title: | Long-term whole-body vibration training in two late-onset Pompe disease patients. |
|---|---|
| Authors: | Montagnese, Federica, Thiele, Simone, Wenninger, Stephan, Schoser, Benedikt |
| Source: | Neurological Sciences. Aug2016, Vol. 37 Issue 8, p1357-1360. 4p. |
| Subjects: | Whole-body vibration, Vibration (Mechanics), Glycogen storage disease type II, Applied kinesiology, Pulmonary function tests, Patients |
| Abstract: | The treatment of late-onset Pompe disease (LOPD) relies on enzyme replacement therapy (ERT) and physiotherapy but the most appropriate exercise program is not yet established. Whole-body vibration training (WBVT) has showed promising results, improving motor performances in various populations. Our aim is to assess the effects of WBVT performed by two LOPD patients in addition to ERT and physiotherapy. A side-alternating WBVT lasting 2 years; clinical assessments included: manual muscle testing (MRC sumscore), knee extension and arm flection isometric strength (multi-muscle tester M3diagnos), timed function tests (10 m walking, standing-up from chair, ascending 4-steps), 6 min walking (6 MWT), motor disability (Walton Gardner-Medwin scale), pulmonary function. Follow-up evaluations performed for 9 years since ERT start (pre-WBVT and post-WBVT) are reported for comparison. MRC sumscore improved in both patients (Pt.1:41 → 48, Pt.2:42 → 47) as isometric strength of knee extension (Pt.1: + 62 %, Pt.2: + 26 %) and arm flection (Pt.1: + 88 %, Pt.2: + 66 %), 6 MWT improved in Pt.1 (+75 m). Timed function tests did not greatly change. Patients reported no significant CK elevation or WBVT-related complaints. WBVT may be safely used in LOPD and seems to moderately boost muscle strength in patients receiving ERT and physiotherapy for more than 3 years. Larger cohorts should be studied to better assess WBVT potential as adjunctive exercise tool in LOPD. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 116936142 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Long-term whole-body vibration training in two late-onset Pompe disease patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Montagnese%2C+Federica%22">Montagnese, Federica</searchLink><br /><searchLink fieldCode="AR" term="%22Thiele%2C+Simone%22">Thiele, Simone</searchLink><br /><searchLink fieldCode="AR" term="%22Wenninger%2C+Stephan%22">Wenninger, Stephan</searchLink><br /><searchLink fieldCode="AR" term="%22Schoser%2C+Benedikt%22">Schoser, Benedikt</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Aug2016, Vol. 37 Issue 8, p1357-1360. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Whole-body+vibration%22">Whole-body vibration</searchLink><br /><searchLink fieldCode="DE" term="%22Vibration+%28Mechanics%29%22">Vibration (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Glycogen+storage+disease+type+II%22">Glycogen storage disease type II</searchLink><br /><searchLink fieldCode="DE" term="%22Applied+kinesiology%22">Applied kinesiology</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+function+tests%22">Pulmonary function tests</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The treatment of late-onset Pompe disease (LOPD) relies on enzyme replacement therapy (ERT) and physiotherapy but the most appropriate exercise program is not yet established. Whole-body vibration training (WBVT) has showed promising results, improving motor performances in various populations. Our aim is to assess the effects of WBVT performed by two LOPD patients in addition to ERT and physiotherapy. A side-alternating WBVT lasting 2 years; clinical assessments included: manual muscle testing (MRC sumscore), knee extension and arm flection isometric strength (multi-muscle tester M3diagnos), timed function tests (10 m walking, standing-up from chair, ascending 4-steps), 6 min walking (6 MWT), motor disability (Walton Gardner-Medwin scale), pulmonary function. Follow-up evaluations performed for 9 years since ERT start (pre-WBVT and post-WBVT) are reported for comparison. MRC sumscore improved in both patients (Pt.1:41 → 48, Pt.2:42 → 47) as isometric strength of knee extension (Pt.1: + 62 %, Pt.2: + 26 %) and arm flection (Pt.1: + 88 %, Pt.2: + 66 %), 6 MWT improved in Pt.1 (+75 m). Timed function tests did not greatly change. Patients reported no significant CK elevation or WBVT-related complaints. WBVT may be safely used in LOPD and seems to moderately boost muscle strength in patients receiving ERT and physiotherapy for more than 3 years. Larger cohorts should be studied to better assess WBVT potential as adjunctive exercise tool in LOPD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-016-2612-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 1357 Subjects: – SubjectFull: Whole-body vibration Type: general – SubjectFull: Vibration (Mechanics) Type: general – SubjectFull: Glycogen storage disease type II Type: general – SubjectFull: Applied kinesiology Type: general – SubjectFull: Pulmonary function tests Type: general – SubjectFull: Patients Type: general Titles: – TitleFull: Long-term whole-body vibration training in two late-onset Pompe disease patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Montagnese, Federica – PersonEntity: Name: NameFull: Thiele, Simone – PersonEntity: Name: NameFull: Wenninger, Stephan – PersonEntity: Name: NameFull: Schoser, Benedikt IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 37 – Type: issue Value: 8 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
