View in EDS

Apolipoprotein E ℇ4 and testosterone interact in the risk of Alzheimer's disease in men.

Saved in:
Bibliographic Details
Title: Apolipoprotein E ℇ4 and testosterone interact in the risk of Alzheimer's disease in men.
Authors: Hogervorst, E., Lehmann, D. J., Warden, D. R., McBroom, J., Smith, A. D.
Source: International Journal of Geriatric Psychiatry. Oct2002, Vol. 17 Issue 10, p938-940. 3p. 1 Chart.
Subjects: Testosterone, Alzheimer's disease, Older men, Enzyme-linked immunosorbent assay, Aging
Abstract: Objectives To assess the association between testosterone levels and APOE ℇ4 in cases with AD and controls. Method We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA). Testosterone was measured using a competitive enzyme immunoassay (Bayer®). Results We found that both low serum testosterone and the interaction between testosterone and APOE ℇ4 were associated with AD. Furthermore, testosterone levels were lower in APOE ℇ4-positive controls (mean: 11.3 nmol/L) than in controls without the allele (19.1 nmol/L). Conclusions Low testosterone is potentially a modifiable risk factor, which may prove relevant to APOE ℇ4 carriers who are at risk of AD. Copyright © 2002 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 11821858
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Apolipoprotein E ℇ4 and testosterone interact in the risk of Alzheimer's disease in men.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hogervorst%2C+E%2E%22">Hogervorst, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lehmann%2C+D%2E+J%2E%22">Lehmann, D. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Warden%2C+D%2E+R%2E%22">Warden, D. R.</searchLink><br /><searchLink fieldCode="AR" term="%22McBroom%2C+J%2E%22">McBroom, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+A%2E+D%2E%22">Smith, A. D.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. Oct2002, Vol. 17 Issue 10, p938-940. 3p. 1 Chart.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Testosterone%22">Testosterone</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Older+men%22">Older men</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-linked+immunosorbent+assay%22">Enzyme-linked immunosorbent assay</searchLink><br /><searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives To assess the association between testosterone levels and APOE ℇ4 in cases with AD and controls. Method We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA). Testosterone was measured using a competitive enzyme immunoassay (Bayer®). Results We found that both low serum testosterone and the interaction between testosterone and APOE ℇ4 were associated with AD. Furthermore, testosterone levels were lower in APOE ℇ4-positive controls (mean: 11.3 nmol/L) than in controls without the allele (19.1 nmol/L). Conclusions Low testosterone is potentially a modifiable risk factor, which may prove relevant to APOE ℇ4 carriers who are at risk of AD. Copyright © 2002 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11821858
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/gps.714
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 3
        StartPage: 938
    Subjects:
      – SubjectFull: Testosterone
        Type: general
      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Older men
        Type: general
      – SubjectFull: Enzyme-linked immunosorbent assay
        Type: general
      – SubjectFull: Aging
        Type: general
    Titles:
      – TitleFull: Apolipoprotein E ℇ4 and testosterone interact in the risk of Alzheimer's disease in men.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hogervorst, E.
      – PersonEntity:
          Name:
            NameFull: Lehmann, D. J.
      – PersonEntity:
          Name:
            NameFull: Warden, D. R.
      – PersonEntity:
          Name:
            NameFull: McBroom, J.
      – PersonEntity:
          Name:
            NameFull: Smith, A. D.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2002
              Type: published
              Y: 2002
          Identifiers:
            – Type: issn-print
              Value: 08856230
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: International Journal of Geriatric Psychiatry
              Type: main
ResultId 1