View in EDS HTML Full Text PDF Full Text

Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.

Saved in:
Bibliographic Details
Title: Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.
Authors: Gensicke, H., Wicht, A., Bill, O., Zini, A., Costa, P., Kägi, G., Stark, R., Seiffge, D. J., Traenka, C., Peters, N., Bonati, L. H., Giovannini, G., De Marchis, G. M., Poli, L., Polymeris, A., Vanacker, P., Sarikaya, H., Lyrer, P. A., Pezzini, A., Vandelli, L.
Source: European Journal of Neurology. Dec2016, Vol. 23 Issue 12, p1705-1712. 8p. 4 Charts, 1 Graph.
Subjects: Body mass index, Health outcome assessment, Stroke patients, Thrombolytic therapy, Hemorrhage risk factors, Medical care
Abstract: Background and purpose The impact of body mass index ( BMI) on outcome in stroke patients treated with intravenous thrombolysis ( IVT) was investigated. Methods In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage ( sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m2) from underweight (<18.5 kg/m2), overweight (25-29.9 kg/m2) and obese (≥30 kg/m2) patients. Univariable and multivariable regression analyses with adjustments for age and stroke severity were done and odds ratios with 95% confidence intervals [OR (95% CI)] were calculated. Results Of 1798 patients, 730 (40.6%) were normal weight, 55 (3.1%) were underweight, 717 (39.9%) overweight and 295 (16.4%) obese. Poor outcome occurred in 38.1% of normal weight patients and did not differ significantly from underweight (45.5%), overweight (36.1%) and obese (32.5%) patients. The same was true for death (9.5% vs. 14.5%, 9.6% and 7.5%) and sICH (3.9% vs. 5.5%, 4.3%, 2.7%). Neither in univariable nor in multivariable analyses did the risks of poor outcome, death or sICH differ significantly between BMI groups. BMI as a continuous variable was not associated with poor outcome, death or sICH in unadjusted [ OR (95% CI) 0.99 (0.97-1.01), 0.98 (0.95-1.02), 0.98 (0.94-1.04)] or adjusted analyses [ OR (95% CI) 1.01 (0.98-1.03), 0.99 (0.95-1.05), 1.01 (0.97-1.05)], respectively. Conclusion In this largest study to date, investigating the impact of BMI in IVT-treated stroke patients, BMI had no prognostic meaning with regard to 3-month functional outcome, death or occurrence of sICH. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 119752285
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gensicke%2C+H%2E%22&quot;&gt;Gensicke, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wicht%2C+A%2E%22&quot;&gt;Wicht, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bill%2C+O%2E%22&quot;&gt;Bill, O.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zini%2C+A%2E%22&quot;&gt;Zini, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Costa%2C+P%2E%22&quot;&gt;Costa, P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22K&#228;gi%2C+G%2E%22&quot;&gt;K&#228;gi, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stark%2C+R%2E%22&quot;&gt;Stark, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Seiffge%2C+D%2E+J%2E%22&quot;&gt;Seiffge, D. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Traenka%2C+C%2E%22&quot;&gt;Traenka, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Peters%2C+N%2E%22&quot;&gt;Peters, N.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bonati%2C+L%2E+H%2E%22&quot;&gt;Bonati, L. H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giovannini%2C+G%2E%22&quot;&gt;Giovannini, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22De+Marchis%2C+G%2E+M%2E%22&quot;&gt;De Marchis, G. M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Poli%2C+L%2E%22&quot;&gt;Poli, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Polymeris%2C+A%2E%22&quot;&gt;Polymeris, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vanacker%2C+P%2E%22&quot;&gt;Vanacker, P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sarikaya%2C+H%2E%22&quot;&gt;Sarikaya, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lyrer%2C+P%2E+A%2E%22&quot;&gt;Lyrer, P. A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pezzini%2C+A%2E%22&quot;&gt;Pezzini, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vandelli%2C+L%2E%22&quot;&gt;Vandelli, L.&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Dec2016, Vol. 23 Issue 12, p1705-1712. 8p. 4 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Body+mass+index%22&quot;&gt;Body mass index&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Health+outcome+assessment%22&quot;&gt;Health outcome assessment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Stroke+patients%22&quot;&gt;Stroke patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Thrombolytic+therapy%22&quot;&gt;Thrombolytic therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hemorrhage+risk+factors%22&quot;&gt;Hemorrhage risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+care%22&quot;&gt;Medical care&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose The impact of body mass index ( BMI) on outcome in stroke patients treated with intravenous thrombolysis ( IVT) was investigated. Methods In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage ( sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m2) from underweight (&lt;18.5 kg/m2), overweight (25-29.9 kg/m2) and obese (≥30 kg/m2) patients. Univariable and multivariable regression analyses with adjustments for age and stroke severity were done and odds ratios with 95% confidence intervals [OR (95% CI)] were calculated. Results Of 1798 patients, 730 (40.6%) were normal weight, 55 (3.1%) were underweight, 717 (39.9%) overweight and 295 (16.4%) obese. Poor outcome occurred in 38.1% of normal weight patients and did not differ significantly from underweight (45.5%), overweight (36.1%) and obese (32.5%) patients. The same was true for death (9.5% vs. 14.5%, 9.6% and 7.5%) and sICH (3.9% vs. 5.5%, 4.3%, 2.7%). Neither in univariable nor in multivariable analyses did the risks of poor outcome, death or sICH differ significantly between BMI groups. BMI as a continuous variable was not associated with poor outcome, death or sICH in unadjusted [ OR (95% CI) 0.99 (0.97-1.01), 0.98 (0.95-1.02), 0.98 (0.94-1.04)] or adjusted analyses [ OR (95% CI) 1.01 (0.98-1.03), 0.99 (0.95-1.05), 1.01 (0.97-1.05)], respectively. Conclusion In this largest study to date, investigating the impact of BMI in IVT-treated stroke patients, BMI had no prognostic meaning with regard to 3-month functional outcome, death or occurrence of sICH. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=119752285
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.13071
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1705
    Subjects:
      – SubjectFull: Body mass index
        Type: general
      – SubjectFull: Health outcome assessment
        Type: general
      – SubjectFull: Stroke patients
        Type: general
      – SubjectFull: Thrombolytic therapy
        Type: general
      – SubjectFull: Hemorrhage risk factors
        Type: general
      – SubjectFull: Medical care
        Type: general
    Titles:
      – TitleFull: Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gensicke, H.
      – PersonEntity:
          Name:
            NameFull: Wicht, A.
      – PersonEntity:
          Name:
            NameFull: Bill, O.
      – PersonEntity:
          Name:
            NameFull: Zini, A.
      – PersonEntity:
          Name:
            NameFull: Costa, P.
      – PersonEntity:
          Name:
            NameFull: Kägi, G.
      – PersonEntity:
          Name:
            NameFull: Stark, R.
      – PersonEntity:
          Name:
            NameFull: Seiffge, D. J.
      – PersonEntity:
          Name:
            NameFull: Traenka, C.
      – PersonEntity:
          Name:
            NameFull: Peters, N.
      – PersonEntity:
          Name:
            NameFull: Bonati, L. H.
      – PersonEntity:
          Name:
            NameFull: Giovannini, G.
      – PersonEntity:
          Name:
            NameFull: De Marchis, G. M.
      – PersonEntity:
          Name:
            NameFull: Poli, L.
      – PersonEntity:
          Name:
            NameFull: Polymeris, A.
      – PersonEntity:
          Name:
            NameFull: Vanacker, P.
      – PersonEntity:
          Name:
            NameFull: Sarikaya, H.
      – PersonEntity:
          Name:
            NameFull: Lyrer, P. A.
      – PersonEntity:
          Name:
            NameFull: Pezzini, A.
      – PersonEntity:
          Name:
            NameFull: Vandelli, L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 23
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1