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Tau imaging with [18F] THK-5351 in progressive supranuclear palsy.

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Title: Tau imaging with [18F] THK-5351 in progressive supranuclear palsy.
Authors: Ishiki, A., Harada, R., Okamura, N., Tomita, N., Rowe, C. C., Villemagne, V. L., Yanai, K., Kudo, Y., Arai, H., Furumoto, S., Tashiro, M., Furukawa, K.
Source: European Journal of Neurology. Jan2017, Vol. 24 Issue 1, p130-136. 7p.
Subjects: Progressive supranuclear palsy, Tau proteins, Positron emission tomography, Brain physiology, Cerebral cortex, Neurodegeneration, Diagnosis
Abstract: Background and purpose Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions. Aggregates of the microtubule-binding protein, tau, are one of the most important pathogenic molecules in neurodegenerative disorders. Progressive supranuclear palsy ( PSP) is characterized by the deposition of tau proteins in some specific area such as the basal ganglia and brainstem. We tried to detect tau lesions in the brains of living patients with PSP with a novel positron emission tomography (PET) tracer, [18F] THK-5351, which we have recently developed. Methods Paraffin-embedded brain sections of the patients with PSP were used for autoradiography with [3H] THK-5351 and immunohistochemistry. Nine healthy controls, 13 patients with Alzheimer's disease and three patients with PSP participated in this PET study with [18F] THK-5351. To detect amyloid-β deposition, PET imaging with Pittsburgh compound B was also performed. Results Autoradiography in the brain sections of patients with PSP demonstrated [3H] THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibited no remarkable [18F] THK-5351 retention in the temporal cortex, significantly higher tracer retention was observed in the globus pallidus and midbrain. In contrast, amyloid imaging with Pittsburgh compound B showed no remarkable accumulation in the cerebral cortex of PSP. Conclusions We conclude that [18F] THK-5351 PET can potentially be used to detect the regional brain distribution of tau lesions in PSP, thereby facilitating the differential diagnosis of neurodegenerative disorders associated with tau protein. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Tau imaging with [<superscript>18</superscript>F] THK-5351 in progressive supranuclear palsy.
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  Data: <searchLink fieldCode="AR" term="%22Ishiki%2C+A%2E%22">Ishiki, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Harada%2C+R%2E%22">Harada, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Okamura%2C+N%2E%22">Okamura, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Tomita%2C+N%2E%22">Tomita, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Rowe%2C+C%2E+C%2E%22">Rowe, C. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Villemagne%2C+V%2E+L%2E%22">Villemagne, V. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Yanai%2C+K%2E%22">Yanai, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Kudo%2C+Y%2E%22">Kudo, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Arai%2C+H%2E%22">Arai, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Furumoto%2C+S%2E%22">Furumoto, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Tashiro%2C+M%2E%22">Tashiro, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Furukawa%2C+K%2E%22">Furukawa, K.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2017, Vol. 24 Issue 1, p130-136. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Progressive+supranuclear+palsy%22">Progressive supranuclear palsy</searchLink><br /><searchLink fieldCode="DE" term="%22Tau+proteins%22">Tau proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+cortex%22">Cerebral cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink>
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  Data: Background and purpose Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions. Aggregates of the microtubule-binding protein, tau, are one of the most important pathogenic molecules in neurodegenerative disorders. Progressive supranuclear palsy ( PSP) is characterized by the deposition of tau proteins in some specific area such as the basal ganglia and brainstem. We tried to detect tau lesions in the brains of living patients with PSP with a novel positron emission tomography (PET) tracer, [18F] THK-5351, which we have recently developed. Methods Paraffin-embedded brain sections of the patients with PSP were used for autoradiography with [3H] THK-5351 and immunohistochemistry. Nine healthy controls, 13 patients with Alzheimer's disease and three patients with PSP participated in this PET study with [18F] THK-5351. To detect amyloid-β deposition, PET imaging with Pittsburgh compound B was also performed. Results Autoradiography in the brain sections of patients with PSP demonstrated [3H] THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibited no remarkable [18F] THK-5351 retention in the temporal cortex, significantly higher tracer retention was observed in the globus pallidus and midbrain. In contrast, amyloid imaging with Pittsburgh compound B showed no remarkable accumulation in the cerebral cortex of PSP. Conclusions We conclude that [18F] THK-5351 PET can potentially be used to detect the regional brain distribution of tau lesions in PSP, thereby facilitating the differential diagnosis of neurodegenerative disorders associated with tau protein. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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