View in EDS PDF Full Text

Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement.

Saved in:
Bibliographic Details
Title: Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement.
Authors: Spoelder, Marcia, Hesseling, Peter, Styles, Matthew, Baars, Annemarie M., Lozeman‐van ‘t Klooster, José G., Lesscher, Heidi M. B., Vanderschuren, Louk J. M. J., Dalley, Jeffrey
Source: European Journal of Neuroscience. Jan2017, Vol. 45 Issue 1, p147-158. 12p. 1 Diagram, 3 Charts, 3 Graphs.
Subjects: Dopaminergic neurons, Neural transmission, Reinforcement (Psychology), Psychology of alcoholism, Laboratory rats
Abstract: Dopaminergic neurotransmission in the striatum has been widely implicated in the reinforcing properties of substances of abuse. However, the striatum is functionally heterogeneous, and previous work has mostly focused on psychostimulant drugs. Therefore, we investigated how dopamine within striatal subregions modulates alcohol-directed behaviour in rats. We assessed the effects of infusion of the dopamine receptor antagonist alpha-flupenthixol into the shell and core of the nucleus accumbens ( NAcc) and the dorsolateral striatum ( DLS) on responding for alcohol under fixed ratio 1 ( FR1) and progressive ratio ( PR) schedules of reinforcement. Bilateral infusion of alpha-flupenthixol into the NAcc shell reduced responding for alcohol under both the FR1 (15 μg/side) and the PR schedule (3.75-15 μg/side) of reinforcement. Infusion of alpha-flupenthixol into the NAcc core (7.5-15 μg/side) also decreased responding for alcohol under both schedules. By contrast, alpha-flupenthixol infusion into the DLS did not affect FR1 responding, but reduced responding under the PR schedule (15 μg/side). The decreases in responding were related to earlier termination of responding during the session, whereas the onset and rate of responding remained largely unaffected. Together, these data suggest that dopamine in the NAcc shell is involved in the incentive motivation for alcohol, whereas DLS dopamine comes into play when obtaining alcohol requires high levels of effort. In contrast, NAcc core dopamine appears to play a more general role in alcohol reinforcement. In conclusion, dopaminergic neurotransmission acts in concert in subregions of the striatum to modulate different aspects of alcohol-directed behaviour. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 120505066
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Spoelder%2C+Marcia%22">Spoelder, Marcia</searchLink><br /><searchLink fieldCode="AR" term="%22Hesseling%2C+Peter%22">Hesseling, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Styles%2C+Matthew%22">Styles, Matthew</searchLink><br /><searchLink fieldCode="AR" term="%22Baars%2C+Annemarie+M%2E%22">Baars, Annemarie M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lozeman‐van+‘t+Klooster%2C+José+G%2E%22">Lozeman‐van ‘t Klooster, José G.</searchLink><br /><searchLink fieldCode="AR" term="%22Lesscher%2C+Heidi+M%2E+B%2E%22">Lesscher, Heidi M. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Vanderschuren%2C+Louk+J%2E+M%2E+J%2E%22">Vanderschuren, Louk J. M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dalley%2C+Jeffrey%22">Dalley, Jeffrey</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jan2017, Vol. 45 Issue 1, p147-158. 12p. 1 Diagram, 3 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Reinforcement+%28Psychology%29%22">Reinforcement (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+alcoholism%22">Psychology of alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Dopaminergic neurotransmission in the striatum has been widely implicated in the reinforcing properties of substances of abuse. However, the striatum is functionally heterogeneous, and previous work has mostly focused on psychostimulant drugs. Therefore, we investigated how dopamine within striatal subregions modulates alcohol-directed behaviour in rats. We assessed the effects of infusion of the dopamine receptor antagonist alpha-flupenthixol into the shell and core of the nucleus accumbens ( NAcc) and the dorsolateral striatum ( DLS) on responding for alcohol under fixed ratio 1 ( FR1) and progressive ratio ( PR) schedules of reinforcement. Bilateral infusion of alpha-flupenthixol into the NAcc shell reduced responding for alcohol under both the FR1 (15 μg/side) and the PR schedule (3.75-15 μg/side) of reinforcement. Infusion of alpha-flupenthixol into the NAcc core (7.5-15 μg/side) also decreased responding for alcohol under both schedules. By contrast, alpha-flupenthixol infusion into the DLS did not affect FR1 responding, but reduced responding under the PR schedule (15 μg/side). The decreases in responding were related to earlier termination of responding during the session, whereas the onset and rate of responding remained largely unaffected. Together, these data suggest that dopamine in the NAcc shell is involved in the incentive motivation for alcohol, whereas DLS dopamine comes into play when obtaining alcohol requires high levels of effort. In contrast, NAcc core dopamine appears to play a more general role in alcohol reinforcement. In conclusion, dopaminergic neurotransmission acts in concert in subregions of the striatum to modulate different aspects of alcohol-directed behaviour. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=120505066
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.13358
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 147
    Subjects:
      – SubjectFull: Dopaminergic neurons
        Type: general
      – SubjectFull: Neural transmission
        Type: general
      – SubjectFull: Reinforcement (Psychology)
        Type: general
      – SubjectFull: Psychology of alcoholism
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
    Titles:
      – TitleFull: Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Spoelder, Marcia
      – PersonEntity:
          Name:
            NameFull: Hesseling, Peter
      – PersonEntity:
          Name:
            NameFull: Styles, Matthew
      – PersonEntity:
          Name:
            NameFull: Baars, Annemarie M.
      – PersonEntity:
          Name:
            NameFull: Lozeman‐van ‘t Klooster, José G.
      – PersonEntity:
          Name:
            NameFull: Lesscher, Heidi M. B.
      – PersonEntity:
          Name:
            NameFull: Vanderschuren, Louk J. M. J.
      – PersonEntity:
          Name:
            NameFull: Dalley, Jeffrey
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 45
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1