Persistence of impulsivity in pediatric and adolescent patients with obsessive-compulsive disorder.
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| Title: | Persistence of impulsivity in pediatric and adolescent patients with obsessive-compulsive disorder. |
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| Authors: | Yamamuro, Kazuhiko, Ota, Toyosaku, Iida, Junzo, Kishimoto, Naoko, Nakanishi, Yoko, Kishimoto, Toshifumi |
| Source: | Psychiatry & Clinical Neurosciences. Jan2017, Vol. 71 Issue 1, p36-43. 8p. |
| Subjects: | Teenager attitudes, Obsessive-compulsive disorder in adolescence, Serotonin uptake inhibitors, Neurotransmitter uptake inhibitors, Serotonin syndrome |
| Abstract: | Aim Increasing clinical evidence points to impulsivity as a symptom of obsessive-compulsive disorder ( OCD). However, little is known about its persistence over time. Methods In this study, we evaluated the performance of 12 pediatric patients with OCD on the Stroop color-word task, which assesses impulsivity, and compared this with age- and sex-matched controls. In parallel, we measured changes in hemodynamic responses during the task, using near-infrared spectroscopy. As patients in the OCD group were naïve to treatment, we compared results before and after 3-year medication with serotonin reuptake inhibitors. Results We report that, compared with controls, the OCD group had significantly poorer performance and less activation in the prefrontal cortex during the Stroop color-word task. Surprisingly, while serotonin-reuptake-inhibitors treatment reduced OCD symptomology, it did not improve the diminished hemodynamic responses or task performance of these patients. Conclusion Our findings suggest that a persistent deficit exists in the inhibitory control of pediatric patients with OCD; they also provide insight into the pathophysiology of OCD. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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