View in EDS HTML Full Text PDF Full Text

Prognostic significance of proteinuria in stroke patients treated with intravenous thrombolysis.

Saved in:
Bibliographic Details
Title: Prognostic significance of proteinuria in stroke patients treated with intravenous thrombolysis.
Authors: Gensicke, H., Frih, A. A., Strbian, D., Zini, A., Pezzini, A., Padjen, V., Haueter, M., Seiffge, D. J., Mäkitie, L., Traenka, C., Poli, L., Martinez ‐ Majander, N., Putaala, J., Bonati, L. H., Sibolt, G., Giovannini, G., Curtze, S., Beslac ‐ Bumbasirevic, L., Vandelli, L., Lyrer, P. A.
Source: European Journal of Neurology. Feb2017, Vol. 24 Issue 2, p262-269. 8p.
Subjects: Proteinuria diagnosis, Stroke patients, Thrombolytic therapy, Glomerular filtration rate, Intravenous therapy, Cerebral hemorrhage, Mortality risk factors
Abstract: Background and purpose Proteinuria and estimated glomerular filtration rate ( eGFR) are indicators of renal function. Whether proteinuria better predicts outcome than eGFR in stroke patients treated with intravenous thrombolysis ( IVT) remains to be determined. Methods In this explorative multicenter IVT register based study, the presence of urine dipstick proteinuria (yes/no), reduced eGFR (<60 ml/min/1.73 m2) and the coexistence of both with regard to (i) poor 3-month outcome (modified Rankin Scale score 3-6), (ii) death within 3 months and (iii) symptomatic intracranial hemorrhage ( ECASS- II criteria) were compared. Unadjusted and adjusted odds ratios ( ORs) with 95% confidence intervals were calculated. Results Amongst 3398 patients, 881 (26.1%) had proteinuria and 623 (18.3%) reduced eGFR. Proteinuria [ ORadjusted 1.65 (1.37-2.00) and ORadjusted 1.52 (1.24-1.88)] and reduced eGFR [ ORadjusted 1.26 (1.01-1.57) and ORadjusted 1.34 (1.06-1.69)] were independently associated with poor functional outcome and death, respectively. After adding both renal markers to the models, proteinuria [ ORadjusted+eGFR 1.59 (1.31-1.93)] still predicted poor outcome whilst reduced eGFR [ ORadjusted+proteinuria 1.20 (0.96-1.50)] did not. Proteinuria was associated with symptomatic intracranial hemorrhage [ ORadjusted 1.54 (1.09-2.17)] but not reduced eGFR [ ORadjusted 0.96 (0.63-1.62)]. In 234 (6.9%) patients, proteinuria and reduced eGFR were coexistent. Such patients were at the highest risk of poor outcome [ ORadjusted 2.16 (1.54-3.03)] and death [ ORadjusted 2.55 (1.69-3.84)]. Conclusion Proteinuria and reduced eGFR were each independently associated with poor outcome and death but the statistically strongest association appeared for proteinuria. Patients with coexistent proteinuria and reduced eGFR were at the highest risk of poor outcome and death. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 120810685
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Prognostic significance of proteinuria in stroke patients treated with intravenous thrombolysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gensicke%2C+H%2E%22&quot;&gt;Gensicke, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Frih%2C+A%2E+A%2E%22&quot;&gt;Frih, A. A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strbian%2C+D%2E%22&quot;&gt;Strbian, D.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zini%2C+A%2E%22&quot;&gt;Zini, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pezzini%2C+A%2E%22&quot;&gt;Pezzini, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Padjen%2C+V%2E%22&quot;&gt;Padjen, V.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Haueter%2C+M%2E%22&quot;&gt;Haueter, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Seiffge%2C+D%2E+J%2E%22&quot;&gt;Seiffge, D. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22M&#228;kitie%2C+L%2E%22&quot;&gt;M&#228;kitie, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Traenka%2C+C%2E%22&quot;&gt;Traenka, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Poli%2C+L%2E%22&quot;&gt;Poli, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Martinez+‐+Majander%2C+N%2E%22&quot;&gt;Martinez ‐ Majander, N.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Putaala%2C+J%2E%22&quot;&gt;Putaala, J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bonati%2C+L%2E+H%2E%22&quot;&gt;Bonati, L. H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sibolt%2C+G%2E%22&quot;&gt;Sibolt, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giovannini%2C+G%2E%22&quot;&gt;Giovannini, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Curtze%2C+S%2E%22&quot;&gt;Curtze, S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Beslac+‐+Bumbasirevic%2C+L%2E%22&quot;&gt;Beslac ‐ Bumbasirevic, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vandelli%2C+L%2E%22&quot;&gt;Vandelli, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lyrer%2C+P%2E+A%2E%22&quot;&gt;Lyrer, P. A.&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Feb2017, Vol. 24 Issue 2, p262-269. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Proteinuria+diagnosis%22&quot;&gt;Proteinuria diagnosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Stroke+patients%22&quot;&gt;Stroke patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Thrombolytic+therapy%22&quot;&gt;Thrombolytic therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Glomerular+filtration+rate%22&quot;&gt;Glomerular filtration rate&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intravenous+therapy%22&quot;&gt;Intravenous therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cerebral+hemorrhage%22&quot;&gt;Cerebral hemorrhage&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mortality+risk+factors%22&quot;&gt;Mortality risk factors&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose Proteinuria and estimated glomerular filtration rate ( eGFR) are indicators of renal function. Whether proteinuria better predicts outcome than eGFR in stroke patients treated with intravenous thrombolysis ( IVT) remains to be determined. Methods In this explorative multicenter IVT register based study, the presence of urine dipstick proteinuria (yes/no), reduced eGFR (&lt;60 ml/min/1.73 m2) and the coexistence of both with regard to (i) poor 3-month outcome (modified Rankin Scale score 3-6), (ii) death within 3 months and (iii) symptomatic intracranial hemorrhage ( ECASS- II criteria) were compared. Unadjusted and adjusted odds ratios ( ORs) with 95% confidence intervals were calculated. Results Amongst 3398 patients, 881 (26.1%) had proteinuria and 623 (18.3%) reduced eGFR. Proteinuria [ ORadjusted 1.65 (1.37-2.00) and ORadjusted 1.52 (1.24-1.88)] and reduced eGFR [ ORadjusted 1.26 (1.01-1.57) and ORadjusted 1.34 (1.06-1.69)] were independently associated with poor functional outcome and death, respectively. After adding both renal markers to the models, proteinuria [ ORadjusted+eGFR 1.59 (1.31-1.93)] still predicted poor outcome whilst reduced eGFR [ ORadjusted+proteinuria 1.20 (0.96-1.50)] did not. Proteinuria was associated with symptomatic intracranial hemorrhage [ ORadjusted 1.54 (1.09-2.17)] but not reduced eGFR [ ORadjusted 0.96 (0.63-1.62)]. In 234 (6.9%) patients, proteinuria and reduced eGFR were coexistent. Such patients were at the highest risk of poor outcome [ ORadjusted 2.16 (1.54-3.03)] and death [ ORadjusted 2.55 (1.69-3.84)]. Conclusion Proteinuria and reduced eGFR were each independently associated with poor outcome and death but the statistically strongest association appeared for proteinuria. Patients with coexistent proteinuria and reduced eGFR were at the highest risk of poor outcome and death. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=120810685
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.13179
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 262
    Subjects:
      – SubjectFull: Proteinuria diagnosis
        Type: general
      – SubjectFull: Stroke patients
        Type: general
      – SubjectFull: Thrombolytic therapy
        Type: general
      – SubjectFull: Glomerular filtration rate
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Cerebral hemorrhage
        Type: general
      – SubjectFull: Mortality risk factors
        Type: general
    Titles:
      – TitleFull: Prognostic significance of proteinuria in stroke patients treated with intravenous thrombolysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gensicke, H.
      – PersonEntity:
          Name:
            NameFull: Frih, A. A.
      – PersonEntity:
          Name:
            NameFull: Strbian, D.
      – PersonEntity:
          Name:
            NameFull: Zini, A.
      – PersonEntity:
          Name:
            NameFull: Pezzini, A.
      – PersonEntity:
          Name:
            NameFull: Padjen, V.
      – PersonEntity:
          Name:
            NameFull: Haueter, M.
      – PersonEntity:
          Name:
            NameFull: Seiffge, D. J.
      – PersonEntity:
          Name:
            NameFull: Mäkitie, L.
      – PersonEntity:
          Name:
            NameFull: Traenka, C.
      – PersonEntity:
          Name:
            NameFull: Poli, L.
      – PersonEntity:
          Name:
            NameFull: Martinez ‐ Majander, N.
      – PersonEntity:
          Name:
            NameFull: Putaala, J.
      – PersonEntity:
          Name:
            NameFull: Bonati, L. H.
      – PersonEntity:
          Name:
            NameFull: Sibolt, G.
      – PersonEntity:
          Name:
            NameFull: Giovannini, G.
      – PersonEntity:
          Name:
            NameFull: Curtze, S.
      – PersonEntity:
          Name:
            NameFull: Beslac ‐ Bumbasirevic, L.
      – PersonEntity:
          Name:
            NameFull: Vandelli, L.
      – PersonEntity:
          Name:
            NameFull: Lyrer, P. A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1