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Because difficulty is not the same for everyone: the impact of complexity in working memory is associated with cannabinoid 1 receptor genetic variation in young adults.

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Title: Because difficulty is not the same for everyone: the impact of complexity in working memory is associated with cannabinoid 1 receptor genetic variation in young adults.
Authors: Ruiz-Contreras, Alejandra E. (AUTHOR), Román-López, Talía V. (AUTHOR), Caballero-Sánchez, Ulises (AUTHOR), Rosas-Escobar, Cintia B. (AUTHOR), Ortega-Mora, E. Ivett (AUTHOR), Barrera-Tlapa, Miguel A. (AUTHOR), Romero-Hidalgo, Sandra (AUTHOR), Carrillo-Sánchez, Karol (AUTHOR), Hernández-Morales, Salvador (AUTHOR), Vadillo-Ortega, Felipe (AUTHOR), González-Barrios, Juan Antonio (AUTHOR), Méndez-Díaz, Mónica (AUTHOR), Prospéro-García, Oscar (AUTHOR)
Source: Memory. Mar2017, Vol. 25 Issue 3, p335-343. 9p.
Subjects: Short-term memory, Cannabinoid receptors, Young adults, Genotypes, Genetics, Alleles
Abstract: Individual differences in working memory ability are mainly revealed when a demanding challenge is imposed. Here, we have associated cannabinoid 1 (CB1) receptor genetic variation rs2180619 (AA, AG, GG), which is located in a potentialCNR1regulatory sequence, with performance in working memory. Two-hundred and nine Mexican-mestizo healthy young participants (89 women, 120 men, mean age: 23.26 years, SD = 2.85) were challenged to solve a medium (2-back)vs.a high (3-back) difficultyN-back tasks. All subjects responded as expected, performance was better with the medium than the high demand task version, but no differences were found among genotypes while performing each working memory (WM) task. However, the cost of the level of complexity inN-back paradigm was double for GG subjects than for AA subjects. It is noteworthy that an additive-dosage allele relation was found for G allele in terms of cost of level of complexity. These genetic variation results support that the endocannabinoid system, evaluated by rs2180619 polymorphism, is involved in WM ability in humans. [ABSTRACT FROM AUTHOR]
Copyright of Memory is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Because difficulty is not the same for everyone: the impact of complexity in working memory is associated with cannabinoid 1 receptor genetic variation in young adults.
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  Data: <searchLink fieldCode="AR" term="%22Ruiz-Contreras%2C+Alejandra+E%2E%22">Ruiz-Contreras, Alejandra E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Román-López%2C+Talía+V%2E%22">Román-López, Talía V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caballero-Sánchez%2C+Ulises%22">Caballero-Sánchez, Ulises</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rosas-Escobar%2C+Cintia+B%2E%22">Rosas-Escobar, Cintia B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ortega-Mora%2C+E%2E+Ivett%22">Ortega-Mora, E. Ivett</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barrera-Tlapa%2C+Miguel+A%2E%22">Barrera-Tlapa, Miguel A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Romero-Hidalgo%2C+Sandra%22">Romero-Hidalgo, Sandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carrillo-Sánchez%2C+Karol%22">Carrillo-Sánchez, Karol</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hernández-Morales%2C+Salvador%22">Hernández-Morales, Salvador</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vadillo-Ortega%2C+Felipe%22">Vadillo-Ortega, Felipe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22González-Barrios%2C+Juan+Antonio%22">González-Barrios, Juan Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Méndez-Díaz%2C+Mónica%22">Méndez-Díaz, Mónica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prospéro-García%2C+Oscar%22">Prospéro-García, Oscar</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Memory%22">Memory</searchLink>. Mar2017, Vol. 25 Issue 3, p335-343. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Cannabinoid+receptors%22">Cannabinoid receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Young+adults%22">Young adults</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Alleles%22">Alleles</searchLink>
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  Data: Individual differences in working memory ability are mainly revealed when a demanding challenge is imposed. Here, we have associated cannabinoid 1 (CB1) receptor genetic variation rs2180619 (AA, AG, GG), which is located in a potentialCNR1regulatory sequence, with performance in working memory. Two-hundred and nine Mexican-mestizo healthy young participants (89 women, 120 men, mean age: 23.26 years, SD = 2.85) were challenged to solve a medium (2-back)vs.a high (3-back) difficultyN-back tasks. All subjects responded as expected, performance was better with the medium than the high demand task version, but no differences were found among genotypes while performing each working memory (WM) task. However, the cost of the level of complexity inN-back paradigm was double for GG subjects than for AA subjects. It is noteworthy that an additive-dosage allele relation was found for G allele in terms of cost of level of complexity. These genetic variation results support that the endocannabinoid system, evaluated by rs2180619 polymorphism, is involved in WM ability in humans. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Memory is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=120932111
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        Value: 10.1080/09658211.2016.1172642
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        Type: general
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