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Anticonvulsants and suicide attempts in bipolar I disorders.

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Title: Anticonvulsants and suicide attempts in bipolar I disorders.
Authors: Bellivier, F., Belzeaux, R., Scott, J., Courtet, P., Golmard, J.‐L., Azorin, J.‐M.
Source: Acta Psychiatrica Scandinavica. May2017, Vol. 135 Issue 5, p470-478. 9p.
Subjects: Anticonvulsants, Suicide risk factors, Bipolar disorder, Mania, Substance-induced disorders
Abstract: Objective To identify risk factors for suicide attempts ( SA) in individuals commencing treatment for a manic or mixed episode. Method A total of 3390 manic or mixed cases with bipolar disorder ( BD) type I recruited from 14 European countries were included in a prospective, 2-year observational study. Poisson regression models were used to identify individual and treatment factors associated with new SA events. Two multivariate models were built, stratified for the presence or absence of prior SA. Results A total of 302 SA were recorded prospectively; the peak incidence was 0-12 weeks after commencing treatment. In cases with a prior history of SA, risk of SA repetition was associated with younger age of first manic episode ( P = 0.03), rapid cycling ( P < 0.001), history of alcohol and/or substance use disorder ( P < 0.001), number of psychotropic drugs prescribed ( P < 0.001) and initiation of an anticonvulsant at study entry ( P < 0.001). In cases with no previous SA, the first SA event was associated with rapid cycling ( P = 0.02), lifetime history of alcohol use disorder ( P = 0.02) and initiation of an anticonvulsant at study entry ( P = 0.002). Conclusion The introduction of anticonvulsants for a recent-onset manic or mixed episode may be associated with an increased risk of SA. Further BD studies must determine whether this link is causal. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Anticonvulsants and suicide attempts in bipolar I disorders.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Psychiatrica+Scandinavica%22&quot;&gt;Acta Psychiatrica Scandinavica&lt;/searchLink&gt;. May2017, Vol. 135 Issue 5, p470-478. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Anticonvulsants%22&quot;&gt;Anticonvulsants&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Suicide+risk+factors%22&quot;&gt;Suicide risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bipolar+disorder%22&quot;&gt;Bipolar disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mania%22&quot;&gt;Mania&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Substance-induced+disorders%22&quot;&gt;Substance-induced disorders&lt;/searchLink&gt;
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  Data: Objective To identify risk factors for suicide attempts ( SA) in individuals commencing treatment for a manic or mixed episode. Method A total of 3390 manic or mixed cases with bipolar disorder ( BD) type I recruited from 14 European countries were included in a prospective, 2-year observational study. Poisson regression models were used to identify individual and treatment factors associated with new SA events. Two multivariate models were built, stratified for the presence or absence of prior SA. Results A total of 302 SA were recorded prospectively; the peak incidence was 0-12 weeks after commencing treatment. In cases with a prior history of SA, risk of SA repetition was associated with younger age of first manic episode ( P = 0.03), rapid cycling ( P &lt; 0.001), history of alcohol and/or substance use disorder ( P &lt; 0.001), number of psychotropic drugs prescribed ( P &lt; 0.001) and initiation of an anticonvulsant at study entry ( P &lt; 0.001). In cases with no previous SA, the first SA event was associated with rapid cycling ( P = 0.02), lifetime history of alcohol use disorder ( P = 0.02) and initiation of an anticonvulsant at study entry ( P = 0.002). Conclusion The introduction of anticonvulsants for a recent-onset manic or mixed episode may be associated with an increased risk of SA. Further BD studies must determine whether this link is causal. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Suicide risk factors
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      – SubjectFull: Bipolar disorder
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      – SubjectFull: Mania
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      – SubjectFull: Substance-induced disorders
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              Text: May2017
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