Noradrenergic Stimulation Impairs Memory Generalization in Women.
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| Title: | Noradrenergic Stimulation Impairs Memory Generalization in Women. |
|---|---|
| Authors: | Kluen, Lisa Marieke, Agorastos, Agorastos, Wiedemann, Klaus, Schwabe, Lars |
| Source: | Journal of Cognitive Neuroscience. 2017, Vol. 29 Issue 7, p1279-1291. 13p. 1 Diagram, 3 Charts, 2 Graphs. |
| Subjects: | Noradrenergic mechanisms, Neural stimulation, Memory disorders, Women's mental health, Glucocorticoids |
| Abstract: | Memory generalization is essential for adaptive decisionmaking and action. Our ability to generalize across past experiences relies on medial-temporal lobe structures, known to be highly sensitive to stress. Recent evidence suggests that stressful events may indeed interfere with memory generalization. Yet, the mechanisms involved in this generalization impairment are unknown. We tested here whether a pharmacological elevation of major stress mediators--noradrenaline and glucocorticoids--is sufficient to disrupt memory generalization. In a double-blind, placebo-controlled design, healthymen andwomen received orally a placebo, hydrocortisone, the a2-adrenoceptor antagonist yohimbine that leads to increased noradrenergic stimulation, or both drugs, before they completed an associative learning task probing memory generalization. Drugs left learning performance intact. Yohimbine, however, led to a striking generalization impairment in women, but not in men. Hydrocortisone, in turn, had no effect on memory generalization, neither in men nor in women. The present findings indicate that increased noradrenergic activity, but not cortisol, is sufficient to disrupt memory generalization in a sex-specific manner, with relevant implications for stress-related mental disorders characterized by generalization deficits. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 123355613 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Noradrenergic Stimulation Impairs Memory Generalization in Women. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kluen%2C+Lisa+Marieke%22">Kluen, Lisa Marieke</searchLink><br /><searchLink fieldCode="AR" term="%22Agorastos%2C+Agorastos%22">Agorastos, Agorastos</searchLink><br /><searchLink fieldCode="AR" term="%22Wiedemann%2C+Klaus%22">Wiedemann, Klaus</searchLink><br /><searchLink fieldCode="AR" term="%22Schwabe%2C+Lars%22">Schwabe, Lars</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Cognitive+Neuroscience%22">Journal of Cognitive Neuroscience</searchLink>. 2017, Vol. 29 Issue 7, p1279-1291. 13p. 1 Diagram, 3 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Noradrenergic+mechanisms%22">Noradrenergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+stimulation%22">Neural stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Memory+disorders%22">Memory disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Women's+mental+health%22">Women's mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Glucocorticoids%22">Glucocorticoids</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Memory generalization is essential for adaptive decisionmaking and action. Our ability to generalize across past experiences relies on medial-temporal lobe structures, known to be highly sensitive to stress. Recent evidence suggests that stressful events may indeed interfere with memory generalization. Yet, the mechanisms involved in this generalization impairment are unknown. We tested here whether a pharmacological elevation of major stress mediators--noradrenaline and glucocorticoids--is sufficient to disrupt memory generalization. In a double-blind, placebo-controlled design, healthymen andwomen received orally a placebo, hydrocortisone, the a2-adrenoceptor antagonist yohimbine that leads to increased noradrenergic stimulation, or both drugs, before they completed an associative learning task probing memory generalization. Drugs left learning performance intact. Yohimbine, however, led to a striking generalization impairment in women, but not in men. Hydrocortisone, in turn, had no effect on memory generalization, neither in men nor in women. The present findings indicate that increased noradrenergic activity, but not cortisol, is sufficient to disrupt memory generalization in a sex-specific manner, with relevant implications for stress-related mental disorders characterized by generalization deficits. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=123355613 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1162/jocn_a_01118 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1279 Subjects: – SubjectFull: Noradrenergic mechanisms Type: general – SubjectFull: Neural stimulation Type: general – SubjectFull: Memory disorders Type: general – SubjectFull: Women's mental health Type: general – SubjectFull: Glucocorticoids Type: general Titles: – TitleFull: Noradrenergic Stimulation Impairs Memory Generalization in Women. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kluen, Lisa Marieke – PersonEntity: Name: NameFull: Agorastos, Agorastos – PersonEntity: Name: NameFull: Wiedemann, Klaus – PersonEntity: Name: NameFull: Schwabe, Lars IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 0898929X Numbering: – Type: volume Value: 29 – Type: issue Value: 7 Titles: – TitleFull: Journal of Cognitive Neuroscience Type: main |
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