Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder.
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| Title: | Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder. |
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| Authors: | Baczkowski, Blazej, Zutphen, Linda, Siep, Nicolette, Jacob, Gitta, Domes, Gregor, Maier, Simon, Sprenger, Andreas, Senft, Alena, Willenborg, Bastian, Tüscher, Oliver, Arntz, Arnoud, Ven, Vincent |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Sep2017, Vol. 267 Issue 6, p551-565. 15p. |
| Subjects: | Borderline personality disorder, Emotions, Magnetic resonance imaging, Amygdaloid body, Prefrontal cortex |
| Abstract: | Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subsequently, we explored whether the results are common for personality disorders characterized by emotional problems, using additional data of 21 cluster-C personality disorder patients. In contrast to non-patients, BPD patients failed to show increased post-task amygdala resting-state FC with the medial, dorsolateral, ventrolateral PFC, and superior temporal gyrus, but surprisingly exhibited decreased FC with the posterior cingulate cortex and increased FC with the superior parietal lobule. In BPD patients, the emotion regulation task failed to increase resting-state amygdala FC with brain regions essential for effortful emotion regulation, which suggests: (a) altered cognitive control typically used to indirectly alleviate distress by reinterpreting the meaning of emotional stimuli; (b) impaired direct regulation of emotional responses, which might be common for personality disorders; (c) avoidance of self-related appraisals induced by social emotional stimuli. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 124864951 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Baczkowski%2C+Blazej%22">Baczkowski, Blazej</searchLink><br /><searchLink fieldCode="AR" term="%22Zutphen%2C+Linda%22">Zutphen, Linda</searchLink><br /><searchLink fieldCode="AR" term="%22Siep%2C+Nicolette%22">Siep, Nicolette</searchLink><br /><searchLink fieldCode="AR" term="%22Jacob%2C+Gitta%22">Jacob, Gitta</searchLink><br /><searchLink fieldCode="AR" term="%22Domes%2C+Gregor%22">Domes, Gregor</searchLink><br /><searchLink fieldCode="AR" term="%22Maier%2C+Simon%22">Maier, Simon</searchLink><br /><searchLink fieldCode="AR" term="%22Sprenger%2C+Andreas%22">Sprenger, Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22Senft%2C+Alena%22">Senft, Alena</searchLink><br /><searchLink fieldCode="AR" term="%22Willenborg%2C+Bastian%22">Willenborg, Bastian</searchLink><br /><searchLink fieldCode="AR" term="%22Tüscher%2C+Oliver%22">Tüscher, Oliver</searchLink><br /><searchLink fieldCode="AR" term="%22Arntz%2C+Arnoud%22">Arntz, Arnoud</searchLink><br /><searchLink fieldCode="AR" term="%22Ven%2C+Vincent%22">Ven, Vincent</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Sep2017, Vol. 267 Issue 6, p551-565. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Borderline+personality+disorder%22">Borderline personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Emotions%22">Emotions</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subsequently, we explored whether the results are common for personality disorders characterized by emotional problems, using additional data of 21 cluster-C personality disorder patients. In contrast to non-patients, BPD patients failed to show increased post-task amygdala resting-state FC with the medial, dorsolateral, ventrolateral PFC, and superior temporal gyrus, but surprisingly exhibited decreased FC with the posterior cingulate cortex and increased FC with the superior parietal lobule. In BPD patients, the emotion regulation task failed to increase resting-state amygdala FC with brain regions essential for effortful emotion regulation, which suggests: (a) altered cognitive control typically used to indirectly alleviate distress by reinterpreting the meaning of emotional stimuli; (b) impaired direct regulation of emotional responses, which might be common for personality disorders; (c) avoidance of self-related appraisals induced by social emotional stimuli. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-016-0760-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 551 Subjects: – SubjectFull: Borderline personality disorder Type: general – SubjectFull: Emotions Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Amygdaloid body Type: general – SubjectFull: Prefrontal cortex Type: general Titles: – TitleFull: Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Baczkowski, Blazej – PersonEntity: Name: NameFull: Zutphen, Linda – PersonEntity: Name: NameFull: Siep, Nicolette – PersonEntity: Name: NameFull: Jacob, Gitta – PersonEntity: Name: NameFull: Domes, Gregor – PersonEntity: Name: NameFull: Maier, Simon – PersonEntity: Name: NameFull: Sprenger, Andreas – PersonEntity: Name: NameFull: Senft, Alena – PersonEntity: Name: NameFull: Willenborg, Bastian – PersonEntity: Name: NameFull: Tüscher, Oliver – PersonEntity: Name: NameFull: Arntz, Arnoud – PersonEntity: Name: NameFull: Ven, Vincent IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 267 – Type: issue Value: 6 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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