The effects of buspirone on occupancy of dopamine receptors and the rat gambling task.
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| Title: | The effects of buspirone on occupancy of dopamine receptors and the rat gambling task. |
|---|---|
| Authors: | Ciano, Patricia, Cormick, Patrick, Stefan, Cristiana, Wong, Ernest, Kim, Aaron, Remington, Gary, Foll, Bernard |
| Source: | Psychopharmacology. Nov2017, Vol. 234 Issue 22, p3309-3320. 12p. |
| Subjects: | Buspirone, Dopamine receptors, Drug development, Tranquilizing drugs, Laboratory rats |
| Abstract: | Background: The dopamine D3 receptor (DRD) has been proposed as a target for drug development for the treatment of addictive disorders. Recently, the anxiolytic buspirone has been shown to have affinity for DRD and DRD, and interest in repurposing it for addictive disorders has grown. Methods: Binding of [H]-(+)-PHNO in the rat cerebellum and striatum was used to measure occupancy by buspirone of DRD or DRD, respectively. Effects of buspirone in the rat gambling task (rGT) and the five-choice serial reaction time task (5-CSRTT) were examined. Results: Buspirone occupied both the DRD and DRD at high doses and the DRD, but not the DRD, in the narrow dose range of 3 mg/kg. At 10 mg/kg, a disruption of performance on rGT was observed. All measures of performance on the rGT, except for perseverations, were affected at 3 mg/kg. On the 5-CSRTT, omissions were increased. Impairments in the rGT were not mimicked by the effects induced by satiation. Further, buspirone did not impair food-maintained responding under a progressive ratio schedule of reinforcement at any dose, suggesting that the effects of buspirone on the rGT cannot be explained by non-selective actions. Conclusions: Although buspirone had effects on the rGT at the dose that selectively occupied the DRD, the effects found do not parallel those found in previous studies of the effects of selective DRD antagonists on the rGT. Thus, buspirone may impair performance on the rGT through actions at multiple receptor sites. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 125924126 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The effects of buspirone on occupancy of dopamine receptors and the rat gambling task. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ciano%2C+Patricia%22">Ciano, Patricia</searchLink><br /><searchLink fieldCode="AR" term="%22Cormick%2C+Patrick%22">Cormick, Patrick</searchLink><br /><searchLink fieldCode="AR" term="%22Stefan%2C+Cristiana%22">Stefan, Cristiana</searchLink><br /><searchLink fieldCode="AR" term="%22Wong%2C+Ernest%22">Wong, Ernest</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Aaron%22">Kim, Aaron</searchLink><br /><searchLink fieldCode="AR" term="%22Remington%2C+Gary%22">Remington, Gary</searchLink><br /><searchLink fieldCode="AR" term="%22Foll%2C+Bernard%22">Foll, Bernard</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Nov2017, Vol. 234 Issue 22, p3309-3320. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Buspirone%22">Buspirone</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+development%22">Drug development</searchLink><br /><searchLink fieldCode="DE" term="%22Tranquilizing+drugs%22">Tranquilizing drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The dopamine D3 receptor (DRD) has been proposed as a target for drug development for the treatment of addictive disorders. Recently, the anxiolytic buspirone has been shown to have affinity for DRD and DRD, and interest in repurposing it for addictive disorders has grown. Methods: Binding of [H]-(+)-PHNO in the rat cerebellum and striatum was used to measure occupancy by buspirone of DRD or DRD, respectively. Effects of buspirone in the rat gambling task (rGT) and the five-choice serial reaction time task (5-CSRTT) were examined. Results: Buspirone occupied both the DRD and DRD at high doses and the DRD, but not the DRD, in the narrow dose range of 3 mg/kg. At 10 mg/kg, a disruption of performance on rGT was observed. All measures of performance on the rGT, except for perseverations, were affected at 3 mg/kg. On the 5-CSRTT, omissions were increased. Impairments in the rGT were not mimicked by the effects induced by satiation. Further, buspirone did not impair food-maintained responding under a progressive ratio schedule of reinforcement at any dose, suggesting that the effects of buspirone on the rGT cannot be explained by non-selective actions. Conclusions: Although buspirone had effects on the rGT at the dose that selectively occupied the DRD, the effects found do not parallel those found in previous studies of the effects of selective DRD antagonists on the rGT. Thus, buspirone may impair performance on the rGT through actions at multiple receptor sites. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-017-4715-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 3309 Subjects: – SubjectFull: Buspirone Type: general – SubjectFull: Dopamine receptors Type: general – SubjectFull: Drug development Type: general – SubjectFull: Tranquilizing drugs Type: general – SubjectFull: Laboratory rats Type: general Titles: – TitleFull: The effects of buspirone on occupancy of dopamine receptors and the rat gambling task. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ciano, Patricia – PersonEntity: Name: NameFull: Cormick, Patrick – PersonEntity: Name: NameFull: Stefan, Cristiana – PersonEntity: Name: NameFull: Wong, Ernest – PersonEntity: Name: NameFull: Kim, Aaron – PersonEntity: Name: NameFull: Remington, Gary – PersonEntity: Name: NameFull: Foll, Bernard IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 11 Text: Nov2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 234 – Type: issue Value: 22 Titles: – TitleFull: Psychopharmacology Type: main |
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