Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding.
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| Title: | Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. |
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| Authors: | Marinari, Eliana (AUTHOR), Mehonic, Aida (AUTHOR), Curran, Scott (AUTHOR), Gale, Jonathan (AUTHOR), Duke, Thomas (AUTHOR), Baum, Buzz (AUTHOR) |
| Source: | Nature. 4/26/2012, Vol. 484 Issue 7395, p542-545. 4p. 3 Graphs. |
| Abstract: | The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth1,2,3,4, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a model system5 to identify a novel process of crowding-induced cell delamination that balances growth to ensure the development of well-ordered cell packing. In crowded regions of the tissue, a proportion of cells undergo a serial loss of cell–cell junctions and a progressive loss of apical area, before being squeezed out by their neighbours. This path of delamination is recapitulated by a simple computational model of epithelial mechanics, in which stochastic cell loss relieves overcrowding as the system tends towards equilibrium. We show that this process of delamination is mechanistically distinct from apoptosis-mediated cell extrusion6,7,8 and precedes the first signs of cell death. Overall, this analysis reveals a simple mechanism that buffers epithelia against variations in growth. Because live-cell delamination constitutes a mechanistic link between epithelial hyperplasia and cell invasion, this is likely to have important implications for our understanding of the early stages of cancer development. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 128471318 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Marinari%2C+Eliana%22">Marinari, Eliana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehonic%2C+Aida%22">Mehonic, Aida</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Curran%2C+Scott%22">Curran, Scott</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gale%2C+Jonathan%22">Gale, Jonathan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duke%2C+Thomas%22">Duke, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baum%2C+Buzz%22">Baum, Buzz</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 4/26/2012, Vol. 484 Issue 7395, p542-545. 4p. 3 Graphs. – Name: Abstract Label: Abstract Group: Ab Data: The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth1,2,3,4, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a model system5 to identify a novel process of crowding-induced cell delamination that balances growth to ensure the development of well-ordered cell packing. In crowded regions of the tissue, a proportion of cells undergo a serial loss of cell–cell junctions and a progressive loss of apical area, before being squeezed out by their neighbours. This path of delamination is recapitulated by a simple computational model of epithelial mechanics, in which stochastic cell loss relieves overcrowding as the system tends towards equilibrium. We show that this process of delamination is mechanistically distinct from apoptosis-mediated cell extrusion6,7,8 and precedes the first signs of cell death. Overall, this analysis reveals a simple mechanism that buffers epithelia against variations in growth. Because live-cell delamination constitutes a mechanistic link between epithelial hyperplasia and cell invasion, this is likely to have important implications for our understanding of the early stages of cancer development. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=128471318 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature10984 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 542 Titles: – TitleFull: Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Marinari, Eliana – PersonEntity: Name: NameFull: Mehonic, Aida – PersonEntity: Name: NameFull: Curran, Scott – PersonEntity: Name: NameFull: Gale, Jonathan – PersonEntity: Name: NameFull: Duke, Thomas – PersonEntity: Name: NameFull: Baum, Buzz IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 04 Text: 4/26/2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 484 – Type: issue Value: 7395 Titles: – TitleFull: Nature Type: main |
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