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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

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Title: Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.
Authors: Leeman, Dena S. (AUTHOR), Hebestreit, Katja (AUTHOR), Ruetz, Tyson (AUTHOR), Webb, Ashley E. (AUTHOR), McKay, Andrew (AUTHOR), Pollina, Elizabeth A. (AUTHOR), Dulken, Ben W. (AUTHOR), Zhao, Xiaoai (AUTHOR), Yeo, Robin W. (AUTHOR), Ho, Theodore T. (AUTHOR), Mahmoudi, Salah (AUTHOR), Devarajan, Keerthana (AUTHOR), Passegué, Emmanuelle (AUTHOR), Rando, Thomas A. (AUTHOR), Frydman, Judith (AUTHOR), Brunet, Anne (AUTHOR)
Source: Science (pre-March 2025). 3/16/2018, Vol. 359 Issue 6381, p1277-1283. 7p. 4 Color Photographs.
Subjects: Lysosomes, Neural stem cells, Physiological aspects of aging, Proteasomes, Biotransformation (Metabolism), Genetics of aging
Abstract: In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs exhibited differences in their protein homeostasis network. Whereas activated NSCs had active proteasomes, quiescent NSCs contained large lysosomes. Quiescent NSCs from young mice accumulated protein aggregates, and many of these aggregates were stored in large lysosomes. Perturbation of lysosomal activity in quiescent NSCs affected protein-aggregate accumulation and the ability of quiescent NSCs to activate. During aging, quiescent NSCs displayed defects in their lysosomes, increased accumulation of protein aggregates, and reduced ability to activate. Enhancement of the lysosome pathway in old quiescent NSCs cleared protein aggregates and ameliorated the ability of quiescent NSCs to activate, allowing them to regain a more youthful state. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.
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  Data: <searchLink fieldCode="AR" term="%22Leeman%2C+Dena+S%2E%22">Leeman, Dena S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hebestreit%2C+Katja%22">Hebestreit, Katja</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruetz%2C+Tyson%22">Ruetz, Tyson</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Webb%2C+Ashley+E%2E%22">Webb, Ashley E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McKay%2C+Andrew%22">McKay, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pollina%2C+Elizabeth+A%2E%22">Pollina, Elizabeth A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dulken%2C+Ben+W%2E%22">Dulken, Ben W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Xiaoai%22">Zhao, Xiaoai</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeo%2C+Robin+W%2E%22">Yeo, Robin W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ho%2C+Theodore+T%2E%22">Ho, Theodore T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahmoudi%2C+Salah%22">Mahmoudi, Salah</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Devarajan%2C+Keerthana%22">Devarajan, Keerthana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Passegué%2C+Emmanuelle%22">Passegué, Emmanuelle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rando%2C+Thomas+A%2E%22">Rando, Thomas A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frydman%2C+Judith%22">Frydman, Judith</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brunet%2C+Anne%22">Brunet, Anne</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/16/2018, Vol. 359 Issue 6381, p1277-1283. 7p. 4 Color Photographs.
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  Data: <searchLink fieldCode="DE" term="%22Lysosomes%22">Lysosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+stem+cells%22">Neural stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+aspects+of+aging%22">Physiological aspects of aging</searchLink><br /><searchLink fieldCode="DE" term="%22Proteasomes%22">Proteasomes</searchLink><br /><searchLink fieldCode="DE" term="%22Biotransformation+%28Metabolism%29%22">Biotransformation (Metabolism)</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics+of+aging%22">Genetics of aging</searchLink>
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  Label: Abstract
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  Data: In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs exhibited differences in their protein homeostasis network. Whereas activated NSCs had active proteasomes, quiescent NSCs contained large lysosomes. Quiescent NSCs from young mice accumulated protein aggregates, and many of these aggregates were stored in large lysosomes. Perturbation of lysosomal activity in quiescent NSCs affected protein-aggregate accumulation and the ability of quiescent NSCs to activate. During aging, quiescent NSCs displayed defects in their lysosomes, increased accumulation of protein aggregates, and reduced ability to activate. Enhancement of the lysosome pathway in old quiescent NSCs cleared protein aggregates and ameliorated the ability of quiescent NSCs to activate, allowing them to regain a more youthful state. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=128667405
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        Value: 10.1126/science.aag3048
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        Text: English
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        PageCount: 7
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      – SubjectFull: Lysosomes
        Type: general
      – SubjectFull: Neural stem cells
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      – SubjectFull: Physiological aspects of aging
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