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Comorbidity of mitochondrial disease and dementia in patients with idiopathic polyneuropathy.

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Title: Comorbidity of mitochondrial disease and dementia in patients with idiopathic polyneuropathy.
Authors: Samuelsson, K., Mariosa, D., Fang, F., Press, R.
Source: European Journal of Neurology. Jun2018, Vol. 25 Issue 6, p882-887. 6p. 3 Charts.
Subjects: Dementia patients, Mitochondrial pathology, Polyneuropathies, Alzheimer's disease, Epidemiology, Disease risk factors
Abstract: Background and purpose: Studying the comorbidities of chronic idiopathic axonal polyneuropathy (CIAP) might help to better understand its etiopathogenesis. We aimed to assess the associations of mitochondrial disease (MD), Alzheimer's disease (AD) and vascular dementia (VD) with CIAP. Methods: In this nested case‐control study we included 2659 patients with CIAP identified from the Swedish Patient Register and 13 295 age‐ and sex‐matched controls to assess the associations of MD, AD and VD with the subsequent risk of CIAP. We also conducted a follow‐up study of the cases and controls to assess the risk of MD, AD or VD among patients with CIAP in comparison to individuals without CIAP. Results: Individuals with MD had an increased risk of subsequent CIAP [odds ratio (OR), 4.17; 95% confidence intervals (CI), 1.27–13.65], whereas individuals with AD and VD had a decreased risk (OR, 0.18; 95% CI, 0.06–0.59 and OR, 0.17; 95% CI, 0.04–0.69). Patients with CIAP had a ninefold increased risk of subsequent MD [hazard ratio (HR), 9.37; 95% CI, 4.00–21.93], twofold increased risk of VD (HR, 1.97; 95% CI, 1.23–3.16), but no increased risk of AD (HR, 1.33; 95% CI, 0.89–1.98) compared with individuals without CIAP. Conclusions: We found a higher risk of MD among patients with CIAP, both before and after the diagnosis of CIAP. We found a higher risk of VD, but not AD, after the diagnosis of CIAP. The lower risks of AD and VD before CIAP might be due to a reduced surveillance of CIAP symptoms among patients with dementia. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Comorbidity of mitochondrial disease and dementia in patients with idiopathic polyneuropathy.
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  Data: <searchLink fieldCode="AR" term="%22Samuelsson%2C+K%2E%22">Samuelsson, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Mariosa%2C+D%2E%22">Mariosa, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Fang%2C+F%2E%22">Fang, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Press%2C+R%2E%22">Press, R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jun2018, Vol. 25 Issue 6, p882-887. 6p. 3 Charts.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Dementia+patients%22">Dementia patients</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondrial+pathology%22">Mitochondrial pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Polyneuropathies%22">Polyneuropathies</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: Studying the comorbidities of chronic idiopathic axonal polyneuropathy (CIAP) might help to better understand its etiopathogenesis. We aimed to assess the associations of mitochondrial disease (MD), Alzheimer's disease (AD) and vascular dementia (VD) with CIAP. Methods: In this nested case‐control study we included 2659 patients with CIAP identified from the Swedish Patient Register and 13 295 age‐ and sex‐matched controls to assess the associations of MD, AD and VD with the subsequent risk of CIAP. We also conducted a follow‐up study of the cases and controls to assess the risk of MD, AD or VD among patients with CIAP in comparison to individuals without CIAP. Results: Individuals with MD had an increased risk of subsequent CIAP [odds ratio (OR), 4.17; 95% confidence intervals (CI), 1.27–13.65], whereas individuals with AD and VD had a decreased risk (OR, 0.18; 95% CI, 0.06–0.59 and OR, 0.17; 95% CI, 0.04–0.69). Patients with CIAP had a ninefold increased risk of subsequent MD [hazard ratio (HR), 9.37; 95% CI, 4.00–21.93], twofold increased risk of VD (HR, 1.97; 95% CI, 1.23–3.16), but no increased risk of AD (HR, 1.33; 95% CI, 0.89–1.98) compared with individuals without CIAP. Conclusions: We found a higher risk of MD among patients with CIAP, both before and after the diagnosis of CIAP. We found a higher risk of VD, but not AD, after the diagnosis of CIAP. The lower risks of AD and VD before CIAP might be due to a reduced surveillance of CIAP symptoms among patients with dementia. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2018
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