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Investigating the relationship between plasma neuropeptide-S levels and clinical depression.

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Title: Investigating the relationship between plasma neuropeptide-S levels and clinical depression.
Authors: Baykan, Hayriye, Durmaz, Onur, Baykan, Ozgur, Sahin Can, Merve, Kara, Hayrettin, Hismiogullari, Adnan Adil, Karlidere, Tunay
Source: Nordic Journal of Psychiatry. May2018, Vol. 72 Issue 4, p292-295. 4p.
Subjects: Anxiety disorders, Neuropeptides, Central nervous system, Amino acids, Body mass index, Diagnosis
Abstract: Purpose: Neuropeptide-S (NPS) is a novel 20-amino acid peptide, mainly expressed in the central nervous system and endocrine tissues. NPS has been linked to anxiety and fear-related behaviors. The association of NPS with depression in a human population has not been previously examined. The aim of the current study was to explore the potential association of NPS with clinical depression and comorbid anxiety. Materials and methods: Seventy-nine patients diagnosed with major depressive disorder and seventy-eight controls were included in the study. The Hamilton Depression Scale (HAM-D) and Hamilton Anxiety Scale (HAM-A) were used to measure depression and anxiety levels, respectively. Venous blood samples were obtained to measure plasma NPS levels. Results: There were no statistically significant differences between the patients and controls in terms of sex, marital status, and smoking status. Plasma NPS levels were also not significantly different between the patients and controls. In patients with major depressive disorder, HAM-A and HAM-D scores were significantly higher than those of controls. No correlation was found between plasma NPS levels and age, body mass index (BMI), median HAM-A scores, and median HAM-D scores. Conclusions: Despite a significantly high level of comorbid anxiety among the patient group, we found no relationship between plasma NPS levels and depressive symptomatology. [ABSTRACT FROM AUTHOR]
Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Investigating the relationship between plasma neuropeptide-S levels and clinical depression.
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  Data: <searchLink fieldCode="AR" term="%22Baykan%2C+Hayriye%22">Baykan, Hayriye</searchLink><br /><searchLink fieldCode="AR" term="%22Durmaz%2C+Onur%22">Durmaz, Onur</searchLink><br /><searchLink fieldCode="AR" term="%22Baykan%2C+Ozgur%22">Baykan, Ozgur</searchLink><br /><searchLink fieldCode="AR" term="%22Sahin+Can%2C+Merve%22">Sahin Can, Merve</searchLink><br /><searchLink fieldCode="AR" term="%22Kara%2C+Hayrettin%22">Kara, Hayrettin</searchLink><br /><searchLink fieldCode="AR" term="%22Hismiogullari%2C+Adnan+Adil%22">Hismiogullari, Adnan Adil</searchLink><br /><searchLink fieldCode="AR" term="%22Karlidere%2C+Tunay%22">Karlidere, Tunay</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nordic+Journal+of+Psychiatry%22">Nordic Journal of Psychiatry</searchLink>. May2018, Vol. 72 Issue 4, p292-295. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropeptides%22">Neuropeptides</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink>
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  Label: Abstract
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  Data: Purpose: Neuropeptide-S (NPS) is a novel 20-amino acid peptide, mainly expressed in the central nervous system and endocrine tissues. NPS has been linked to anxiety and fear-related behaviors. The association of NPS with depression in a human population has not been previously examined. The aim of the current study was to explore the potential association of NPS with clinical depression and comorbid anxiety. Materials and methods: Seventy-nine patients diagnosed with major depressive disorder and seventy-eight controls were included in the study. The Hamilton Depression Scale (HAM-D) and Hamilton Anxiety Scale (HAM-A) were used to measure depression and anxiety levels, respectively. Venous blood samples were obtained to measure plasma NPS levels. Results: There were no statistically significant differences between the patients and controls in terms of sex, marital status, and smoking status. Plasma NPS levels were also not significantly different between the patients and controls. In patients with major depressive disorder, HAM-A and HAM-D scores were significantly higher than those of controls. No correlation was found between plasma NPS levels and age, body mass index (BMI), median HAM-A scores, and median HAM-D scores. Conclusions: Despite a significantly high level of comorbid anxiety among the patient group, we found no relationship between plasma NPS levels and depressive symptomatology. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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