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The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps.

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Title: The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps.
Authors: Naoki Sugimoto, Tsuguhisa Nakayama, Yoshiyuki Kasai, Daiya Asaka, Ryoto Mitsuyoshi, Tadao Tsurumoto, Shinya Takaishi, Sachiko Omae, Hiromi Kojima, Yasuhiro Tanaka, Shin-Ichi Haruna
Source: Acta Oto-Laryngologica (Supplement). Sep2018, Vol. 138 Issue 9, p830-836. 7p. 1 Chart, 4 Graphs.
Subjects: Cell differentiation, Endotoxins, Gene expression, Immunohistochemistry, Macrophages, Membrane proteins, Messenger RNA, Monocytes, Nasal polyps, Polymerase chain reaction, Sinusitis, Reverse transcriptase polymerase chain reaction, Lipopolysaccharides, Metalloendopeptidases
Abstract: Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is classified into two subtypes: eosinophilic (ECRSwNP) and non-eosinophilic (NECRSwNP). Although the inflammatory patterns of ECRSwNP have been elucidated, NECRSwNP is poorly understood. Aims/objectives: The metalloproteinase ADAM-like decysin 1 (ADAMDEC1) has been reported to play a role in the early stages of the inflammatory response. We investigated the role of ADAMDEC1 in the pathogenesis of CRSwNP. Material and methods: We compared ADAMDEC1 expression in nasal polyp tissue from CRS patients using immunohistochemistry and RT-qPCR. Macrophages were cultured and ADAMDEC1 expression was determined at baseline and after exposure to lipopolysaccharide (LPS). Results: ADAMDEC1 was virtually undetectable in tissues from control patients but was highly expressed in the NECRSwNP group compared with the ECRSwNP group. In nasal polyp tissues, ADAMDEC1 was expressed by CD68-positive cells, with a positive correlation between ADAMDEC1-positive and CD68-positive cells, and also between ADAMDEC1 and CD68 mRNA levels. Furthermore, stimulation of monocyte-derived macrophages with LPS induced ADAMDEC1 expression. Conclusions and significance: This study demonstrates that ADAMDEC1 is involved in the pathogenesis of NECRSwNP, and also bacterial endotoxin signalling in macrophages; however, the underlying mechanism remains to be elucidated. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps.
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  Data: <searchLink fieldCode="AR" term="%22Naoki+Sugimoto%22">Naoki Sugimoto</searchLink><br /><searchLink fieldCode="AR" term="%22Tsuguhisa+Nakayama%22">Tsuguhisa Nakayama</searchLink><br /><searchLink fieldCode="AR" term="%22Yoshiyuki+Kasai%22">Yoshiyuki Kasai</searchLink><br /><searchLink fieldCode="AR" term="%22Daiya+Asaka%22">Daiya Asaka</searchLink><br /><searchLink fieldCode="AR" term="%22Ryoto+Mitsuyoshi%22">Ryoto Mitsuyoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Tadao+Tsurumoto%22">Tadao Tsurumoto</searchLink><br /><searchLink fieldCode="AR" term="%22Shinya+Takaishi%22">Shinya Takaishi</searchLink><br /><searchLink fieldCode="AR" term="%22Sachiko+Omae%22">Sachiko Omae</searchLink><br /><searchLink fieldCode="AR" term="%22Hiromi+Kojima%22">Hiromi Kojima</searchLink><br /><searchLink fieldCode="AR" term="%22Yasuhiro+Tanaka%22">Yasuhiro Tanaka</searchLink><br /><searchLink fieldCode="AR" term="%22Shin-Ichi+Haruna%22">Shin-Ichi Haruna</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica+%28Supplement%29%22">Acta Oto-Laryngologica (Supplement)</searchLink>. Sep2018, Vol. 138 Issue 9, p830-836. 7p. 1 Chart, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Cell+differentiation%22">Cell differentiation</searchLink><br /><searchLink fieldCode="DE" term="%22Endotoxins%22">Endotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Immunohistochemistry%22">Immunohistochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22Membrane+proteins%22">Membrane proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Monocytes%22">Monocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Nasal+polyps%22">Nasal polyps</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerase+chain+reaction%22">Polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Sinusitis%22">Sinusitis</searchLink><br /><searchLink fieldCode="DE" term="%22Reverse+transcriptase+polymerase+chain+reaction%22">Reverse transcriptase polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Lipopolysaccharides%22">Lipopolysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Metalloendopeptidases%22">Metalloendopeptidases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is classified into two subtypes: eosinophilic (ECRSwNP) and non-eosinophilic (NECRSwNP). Although the inflammatory patterns of ECRSwNP have been elucidated, NECRSwNP is poorly understood. Aims/objectives: The metalloproteinase ADAM-like decysin 1 (ADAMDEC1) has been reported to play a role in the early stages of the inflammatory response. We investigated the role of ADAMDEC1 in the pathogenesis of CRSwNP. Material and methods: We compared ADAMDEC1 expression in nasal polyp tissue from CRS patients using immunohistochemistry and RT-qPCR. Macrophages were cultured and ADAMDEC1 expression was determined at baseline and after exposure to lipopolysaccharide (LPS). Results: ADAMDEC1 was virtually undetectable in tissues from control patients but was highly expressed in the NECRSwNP group compared with the ECRSwNP group. In nasal polyp tissues, ADAMDEC1 was expressed by CD68-positive cells, with a positive correlation between ADAMDEC1-positive and CD68-positive cells, and also between ADAMDEC1 and CD68 mRNA levels. Furthermore, stimulation of monocyte-derived macrophages with LPS induced ADAMDEC1 expression. Conclusions and significance: This study demonstrates that ADAMDEC1 is involved in the pathogenesis of NECRSwNP, and also bacterial endotoxin signalling in macrophages; however, the underlying mechanism remains to be elucidated. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00016489.2018.1481296
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 830
    Subjects:
      – SubjectFull: Cell differentiation
        Type: general
      – SubjectFull: Endotoxins
        Type: general
      – SubjectFull: Gene expression
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      – SubjectFull: Immunohistochemistry
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      – SubjectFull: Macrophages
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      – SubjectFull: Membrane proteins
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      – SubjectFull: Messenger RNA
        Type: general
      – SubjectFull: Monocytes
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      – SubjectFull: Nasal polyps
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      – SubjectFull: Polymerase chain reaction
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      – SubjectFull: Sinusitis
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      – SubjectFull: Reverse transcriptase polymerase chain reaction
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      – SubjectFull: Lipopolysaccharides
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      – SubjectFull: Metalloendopeptidases
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      – TitleFull: The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps.
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              Text: Sep2018
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