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Effect of pallidal deep-brain stimulation on articulation rate in dystonia.

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Title: Effect of pallidal deep-brain stimulation on articulation rate in dystonia.
Authors: Rusz, Jan (AUTHOR), Fečíková, Anna (AUTHOR), Tykalová, Tereza (AUTHOR), Jech, Robert (AUTHOR)
Source: Neurological Sciences. Apr2019, Vol. 40 Issue 4, p869-873. 5p. 1 Chart, 1 Graph.
Subjects: Subthalamic nucleus, Globus pallidus, Drug side effects, Biomarkers, Dystonia, Dysarthria, Treatment of dystonia, Basal ganglia, Deep brain stimulation
Abstract: Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS) is an effective treatment for dystonia. However, GPi-DBS may cause important stimulation-induced side effects such as hypokinetic dysarthria, which is particularly manifested by articulation rate abnormalities. However, little data regarding the effect of the location of the electrode and stimulation parameters for pallidal stimulation on articulation rate in dystonia is available. Speech data were acquired from 18 dystonic patients with GPi-DBS and 18 matched healthy controls. Each of dystonic patients was tested twice within 1 day in both the GPi-DBS ON and GPi-DBS OFF stimulation conditions. Compared to healthy controls, the decreased diadochokinetic rate and slower articulation rate in dystonic patients were observed in both stimulation conditions. No significant differences in speech rate measures between stimulation conditions were detected with no relation to contact localization and stimulation intensity. Our findings do not support the use articulation rate as a surrogate marker of stimulation-induced changes to the speech apparatus in dystonia. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effect of pallidal deep-brain stimulation on articulation rate in dystonia.
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  Data: <searchLink fieldCode="AR" term="%22Rusz%2C+Jan%22">Rusz, Jan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fečíková%2C+Anna%22">Fečíková, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tykalová%2C+Tereza%22">Tykalová, Tereza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jech%2C+Robert%22">Jech, Robert</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Apr2019, Vol. 40 Issue 4, p869-873. 5p. 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Subthalamic+nucleus%22">Subthalamic nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Globus+pallidus%22">Globus pallidus</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Dystonia%22">Dystonia</searchLink><br /><searchLink fieldCode="DE" term="%22Dysarthria%22">Dysarthria</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+dystonia%22">Treatment of dystonia</searchLink><br /><searchLink fieldCode="DE" term="%22Basal+ganglia%22">Basal ganglia</searchLink><br /><searchLink fieldCode="DE" term="%22Deep+brain+stimulation%22">Deep brain stimulation</searchLink>
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  Data: Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS) is an effective treatment for dystonia. However, GPi-DBS may cause important stimulation-induced side effects such as hypokinetic dysarthria, which is particularly manifested by articulation rate abnormalities. However, little data regarding the effect of the location of the electrode and stimulation parameters for pallidal stimulation on articulation rate in dystonia is available. Speech data were acquired from 18 dystonic patients with GPi-DBS and 18 matched healthy controls. Each of dystonic patients was tested twice within 1 day in both the GPi-DBS ON and GPi-DBS OFF stimulation conditions. Compared to healthy controls, the decreased diadochokinetic rate and slower articulation rate in dystonic patients were observed in both stimulation conditions. No significant differences in speech rate measures between stimulation conditions were detected with no relation to contact localization and stimulation intensity. Our findings do not support the use articulation rate as a surrogate marker of stimulation-induced changes to the speech apparatus in dystonia. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-019-3702-5
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        Text: English
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        Type: general
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      – SubjectFull: Dystonia
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      – SubjectFull: Basal ganglia
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      – SubjectFull: Deep brain stimulation
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      – TitleFull: Effect of pallidal deep-brain stimulation on articulation rate in dystonia.
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              Text: Apr2019
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