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Characterization of traumatic spinal cord injury model in relation to neuropathic pain in the rat.

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Title: Characterization of traumatic spinal cord injury model in relation to neuropathic pain in the rat.
Authors: Batista, Chary Marquez, Mariano, Eric Domingos, Onuchic, Fernando, Dale, Camila Squarzoni, dos Santos, Gustavo Bispo, Cristante, Alexandre Fogaça, Otoch, Jose Pinhata, Teixeira, Manoel Jacobsen, Morgalla, Matthias, Lepski, Guilherme
Source: Somatosensory & Motor Research. Mar2019, Vol. 36 Issue 1, p14-23. 10p. 2 Color Photographs, 2 Charts, 1 Graph.
Subjects: New York University, Spinal cord injuries, Chronic pain, Therapeutics, Pain, Spinal cord
Abstract: Purpose/aim: Neuropathic pain following spinal cord injury (SCI) has a tremendous impact on patient's quality of life, and frequently is the most limiting aspect of the disease. In view of the severity of this condition and the absence of effective treatments, the establishment of a reliable animal model that reproduces neuropathic pain after injury is crucial for a better understanding of the pathophysiology and for the development of new therapeutic strategies. Thus, the objective of the present study was to standardize the traumatic SCI model in relation to neuropathic pain. Materials and methods: Wistar rats were submitted to SCI of mild intensity (pendulum height 12.5 mm) or moderate intensity (pendulum height 25 mm) using the New York University Impactor equipment. Behavioural assessment was performed during 8 weeks. Thereafter, spinal cords were processed for immunohistochemistry. Results: The animals of the moderate injury group in comparison with mild injury had a greater motor function deficit, worse mechanical allodynia, and latter bladder recovery; moreover, histological analysis revealed more extensive lesions with lower neuronal population. Conclusions: Our study suggests that moderate SCI causes a progressive and long-lasting painful condition (at least 8 weeks), in addition to motor impairment, and thus represents a reliable animal model for the study of chronic neuropathic pain after SCI. [ABSTRACT FROM AUTHOR]
Copyright of Somatosensory & Motor Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Characterization of traumatic spinal cord injury model in relation to neuropathic pain in the rat.
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  Data: <searchLink fieldCode="AR" term="%22Batista%2C+Chary+Marquez%22">Batista, Chary Marquez</searchLink><br /><searchLink fieldCode="AR" term="%22Mariano%2C+Eric+Domingos%22">Mariano, Eric Domingos</searchLink><br /><searchLink fieldCode="AR" term="%22Onuchic%2C+Fernando%22">Onuchic, Fernando</searchLink><br /><searchLink fieldCode="AR" term="%22Dale%2C+Camila+Squarzoni%22">Dale, Camila Squarzoni</searchLink><br /><searchLink fieldCode="AR" term="%22dos+Santos%2C+Gustavo+Bispo%22">dos Santos, Gustavo Bispo</searchLink><br /><searchLink fieldCode="AR" term="%22Cristante%2C+Alexandre+Fogaça%22">Cristante, Alexandre Fogaça</searchLink><br /><searchLink fieldCode="AR" term="%22Otoch%2C+Jose+Pinhata%22">Otoch, Jose Pinhata</searchLink><br /><searchLink fieldCode="AR" term="%22Teixeira%2C+Manoel+Jacobsen%22">Teixeira, Manoel Jacobsen</searchLink><br /><searchLink fieldCode="AR" term="%22Morgalla%2C+Matthias%22">Morgalla, Matthias</searchLink><br /><searchLink fieldCode="AR" term="%22Lepski%2C+Guilherme%22">Lepski, Guilherme</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Somatosensory+%26+Motor+Research%22">Somatosensory & Motor Research</searchLink>. Mar2019, Vol. 36 Issue 1, p14-23. 10p. 2 Color Photographs, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22New+York+University%22">New York University</searchLink><br /><searchLink fieldCode="DE" term="%22Spinal+cord+injuries%22">Spinal cord injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+pain%22">Chronic pain</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Pain%22">Pain</searchLink><br /><searchLink fieldCode="DE" term="%22Spinal+cord%22">Spinal cord</searchLink>
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  Data: Purpose/aim: Neuropathic pain following spinal cord injury (SCI) has a tremendous impact on patient's quality of life, and frequently is the most limiting aspect of the disease. In view of the severity of this condition and the absence of effective treatments, the establishment of a reliable animal model that reproduces neuropathic pain after injury is crucial for a better understanding of the pathophysiology and for the development of new therapeutic strategies. Thus, the objective of the present study was to standardize the traumatic SCI model in relation to neuropathic pain. Materials and methods: Wistar rats were submitted to SCI of mild intensity (pendulum height 12.5 mm) or moderate intensity (pendulum height 25 mm) using the New York University Impactor equipment. Behavioural assessment was performed during 8 weeks. Thereafter, spinal cords were processed for immunohistochemistry. Results: The animals of the moderate injury group in comparison with mild injury had a greater motor function deficit, worse mechanical allodynia, and latter bladder recovery; moreover, histological analysis revealed more extensive lesions with lower neuronal population. Conclusions: Our study suggests that moderate SCI causes a progressive and long-lasting painful condition (at least 8 weeks), in addition to motor impairment, and thus represents a reliable animal model for the study of chronic neuropathic pain after SCI. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Somatosensory & Motor Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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