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Cerebellar parcellation in schizophrenia and bipolar disorder.

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Title: Cerebellar parcellation in schizophrenia and bipolar disorder.
Authors: Laidi, C. (AUTHOR), Hajek, T. (AUTHOR), Spaniel, F. (AUTHOR), Kolenic, M. (AUTHOR), d'Albis, M.‐A. (AUTHOR), Sarrazin, S. (AUTHOR), Mangin, J.‐F. (AUTHOR), Duchesnay, E. (AUTHOR), Brambilla, P. (AUTHOR), Wessa, M. (AUTHOR), Linke, J. (AUTHOR), Polosan, M. (AUTHOR), Favre, P. (AUTHOR), Versace, A. L. (AUTHOR), Phillips, M. L. (AUTHOR), Manjon, J. V. (AUTHOR), Romero, J. E. (AUTHOR), Hozer, F. (AUTHOR), Leboyer, M. (AUTHOR), Coupe, P. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Nov2019, Vol. 140 Issue 5, p468-476. 9p. 1 Color Photograph, 3 Charts, 1 Graph.
Subjects: Bipolar disorder, Schizophrenia, Cerebellum, Therapeutic use of lithium
Abstract: Objective: The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. Methods: Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. Results: Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent‐onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. Conclusion: Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cerebellar parcellation in schizophrenia and bipolar disorder.
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  Data: <searchLink fieldCode="AR" term="%22Laidi%2C+C%2E%22">Laidi, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hajek%2C+T%2E%22">Hajek, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spaniel%2C+F%2E%22">Spaniel, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kolenic%2C+M%2E%22">Kolenic, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22d'Albis%2C+M%2E‐A%2E%22">d'Albis, M.‐A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sarrazin%2C+S%2E%22">Sarrazin, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mangin%2C+J%2E‐F%2E%22">Mangin, J.‐F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duchesnay%2C+E%2E%22">Duchesnay, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brambilla%2C+P%2E%22">Brambilla, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wessa%2C+M%2E%22">Wessa, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Linke%2C+J%2E%22">Linke, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Polosan%2C+M%2E%22">Polosan, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Favre%2C+P%2E%22">Favre, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Versace%2C+A%2E+L%2E%22">Versace, A. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Phillips%2C+M%2E+L%2E%22">Phillips, M. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manjon%2C+J%2E+V%2E%22">Manjon, J. V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Romero%2C+J%2E+E%2E%22">Romero, J. E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hozer%2C+F%2E%22">Hozer, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leboyer%2C+M%2E%22">Leboyer, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coupe%2C+P%2E%22">Coupe, P.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Nov2019, Vol. 140 Issue 5, p468-476. 9p. 1 Color Photograph, 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellum%22">Cerebellum</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+lithium%22">Therapeutic use of lithium</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. Methods: Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. Results: Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent‐onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. Conclusion: Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/acps.13087
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