View in EDS HTML Full Text PDF Full Text

Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort.

Saved in:
Bibliographic Details
Title: Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort.
Authors: Fond, G. (AUTHOR), Godin, O. (AUTHOR), Boyer, L. (AUTHOR), Berna, F. (AUTHOR), Andrianarisoa, M. (AUTHOR), Coulon, N. (AUTHOR), Brunel, L. (AUTHOR), Bulzacka, E. (AUTHOR), Aouizerate, B. (AUTHOR), Capdevielle, D. (AUTHOR), Chereau, I. (AUTHOR), D'Amato, T. (AUTHOR), Dubertret, C. (AUTHOR), Dubreucq, J. (AUTHOR), Faget, C. (AUTHOR), Leignier, S. (AUTHOR), Lançon, C. (AUTHOR), Mallet, J. (AUTHOR), Misdrahi, D. (AUTHOR), Passerieux, C. (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Dec2019, Vol. 269 Issue 8, p985-992. 8p. 1 Chart, 1 Graph.
Subjects: Schizophrenia, Inflammation, Antipsychotic agents, Tobacco smoke, Metabolic syndrome
Abstract: A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia. Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment, including recording of current treatment. Current psychotic symptomatology was evaluated by the Positive and Negative Syndrome scale for Schizophrenia (PANSS). UTRS was defined by current clozapine treatment + PANSS total score ≥ 70. Functioning was evaluated by the Global Assessment of Functioning scale. High sensitivity CRP (hs-CRP) was measured for each participant as a proxy to define peripheral low-grade inflammation. 609 stabilized community-dwelling SZ subjects (mean age = 32.5 years, 73.6% male gender) have been included. 60 (9.9%) patients were classified in the UTRS group. In multivariate analyses, UTRS has been associated independently with chronic peripheral inflammation (OR = 2.6 [1.2–5.7], p = 0.01), illness duration (0R = 1.1 [1.0–1.2], p = 0.02) and impaired functioning (OR = 0.9 [0.9–0.9], p = 0.0002) after adjustment for age, sex, current daily tobacco smoking, metabolic syndrome and antidepressant consumption. Peripheral low-grade inflammation is associated with UTRS. Future studies should explore if anti-inflammatory strategies are effective in UTRS with chronic low-grade peripheral inflammation. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 139568286
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Fond%2C+G%2E%22">Fond, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Godin%2C+O%2E%22">Godin, O.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boyer%2C+L%2E%22">Boyer, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berna%2C+F%2E%22">Berna, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andrianarisoa%2C+M%2E%22">Andrianarisoa, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coulon%2C+N%2E%22">Coulon, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brunel%2C+L%2E%22">Brunel, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bulzacka%2C+E%2E%22">Bulzacka, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aouizerate%2C+B%2E%22">Aouizerate, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Capdevielle%2C+D%2E%22">Capdevielle, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chereau%2C+I%2E%22">Chereau, I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Amato%2C+T%2E%22">D'Amato, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dubertret%2C+C%2E%22">Dubertret, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dubreucq%2C+J%2E%22">Dubreucq, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faget%2C+C%2E%22">Faget, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leignier%2C+S%2E%22">Leignier, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lançon%2C+C%2E%22">Lançon, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mallet%2C+J%2E%22">Mallet, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Misdrahi%2C+D%2E%22">Misdrahi, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Passerieux%2C+C%2E%22">Passerieux, C.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Dec2019, Vol. 269 Issue 8, p985-992. 8p. 1 Chart, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Tobacco+smoke%22">Tobacco smoke</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+syndrome%22">Metabolic syndrome</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia. Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment, including recording of current treatment. Current psychotic symptomatology was evaluated by the Positive and Negative Syndrome scale for Schizophrenia (PANSS). UTRS was defined by current clozapine treatment + PANSS total score ≥ 70. Functioning was evaluated by the Global Assessment of Functioning scale. High sensitivity CRP (hs-CRP) was measured for each participant as a proxy to define peripheral low-grade inflammation. 609 stabilized community-dwelling SZ subjects (mean age = 32.5 years, 73.6% male gender) have been included. 60 (9.9%) patients were classified in the UTRS group. In multivariate analyses, UTRS has been associated independently with chronic peripheral inflammation (OR = 2.6 [1.2–5.7], p = 0.01), illness duration (0R = 1.1 [1.0–1.2], p = 0.02) and impaired functioning (OR = 0.9 [0.9–0.9], p = 0.0002) after adjustment for age, sex, current daily tobacco smoking, metabolic syndrome and antidepressant consumption. Peripheral low-grade inflammation is associated with UTRS. Future studies should explore if anti-inflammatory strategies are effective in UTRS with chronic low-grade peripheral inflammation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=139568286
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-018-0908-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 985
    Subjects:
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Antipsychotic agents
        Type: general
      – SubjectFull: Tobacco smoke
        Type: general
      – SubjectFull: Metabolic syndrome
        Type: general
    Titles:
      – TitleFull: Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fond, G.
      – PersonEntity:
          Name:
            NameFull: Godin, O.
      – PersonEntity:
          Name:
            NameFull: Boyer, L.
      – PersonEntity:
          Name:
            NameFull: Berna, F.
      – PersonEntity:
          Name:
            NameFull: Andrianarisoa, M.
      – PersonEntity:
          Name:
            NameFull: Coulon, N.
      – PersonEntity:
          Name:
            NameFull: Brunel, L.
      – PersonEntity:
          Name:
            NameFull: Bulzacka, E.
      – PersonEntity:
          Name:
            NameFull: Aouizerate, B.
      – PersonEntity:
          Name:
            NameFull: Capdevielle, D.
      – PersonEntity:
          Name:
            NameFull: Chereau, I.
      – PersonEntity:
          Name:
            NameFull: D'Amato, T.
      – PersonEntity:
          Name:
            NameFull: Dubertret, C.
      – PersonEntity:
          Name:
            NameFull: Dubreucq, J.
      – PersonEntity:
          Name:
            NameFull: Faget, C.
      – PersonEntity:
          Name:
            NameFull: Leignier, S.
      – PersonEntity:
          Name:
            NameFull: Lançon, C.
      – PersonEntity:
          Name:
            NameFull: Mallet, J.
      – PersonEntity:
          Name:
            NameFull: Misdrahi, D.
      – PersonEntity:
          Name:
            NameFull: Passerieux, C.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 269
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1