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Exposure-induced changes of plasma metabolome and gene expression in patients with panic disorder.

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Bibliographic Details
Title:	Exposure-induced changes of plasma metabolome and gene expression in patients with panic disorder.
Authors:	Martins, Jade (AUTHOR), Czamara, Darina (AUTHOR), Lange, Jennifer (AUTHOR), Dethloff, Frederik (AUTHOR), Binder, Elisabeth B. (AUTHOR), Turck, Chris W. (AUTHOR), Erhardt, Angelika (AUTHOR)
Source:	Depression & Anxiety (1091-4269). Dec2019, Vol. 36 Issue 12, p1173-1181. 9p. 4 Charts, 3 Graphs.
Subjects:	Panic disorders, Gene expression, Panic attacks, Agoraphobia, Anxiety disorders, Mental illness
Abstract:	Background: Anxiety disorders including panic disorder (PD) are the most prevalent psychiatric diseases leading to high disability and burden in the general population. Acute panic attacks are distinctive for PD but also frequent in other anxiety disorders. The neurobiology or specific molecular changes leading to and present during panic attacks are insufficiently known so far.Methods: In the present pilot study, we investigated dynamic metabolomic and gene expression changes in peripheral blood of patients with PD (n = 25) during two exposure-induced acute panic attacks.Results: The results show that the metabolite glyoxylate was dynamically regulated in peripheral blood. Additionally, glyoxylate levels were associated with basal anxiety levels and showed gender-related differences at baseline. As glyoxylate is part of the degradation circuit of cholecystokinin, this suggests that this neuropeptide might be directly involved in exposure-induced panic attacks. Only gene expression changes of very small magnitude were observed in this experimental setting.Conclusions: From this first metabolome and gene expression study in exposure-induced acute panic attacks in PD we conclude that metabolites can potentially serve as dynamic markers for different anxiety states. However, these findings have to be replicated in cohorts with greater sample sizes. [ABSTRACT FROM AUTHOR]
	Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection
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