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Development of bipolar disorder and other comorbidity among youth with attention‐deficit/hyperactivity disorder.

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Title: Development of bipolar disorder and other comorbidity among youth with attention‐deficit/hyperactivity disorder.
Authors: Arnold, L. Eugene, Van Meter, Anna R., Fristad, Mary A., Youngstrom, Eric A., Birmaher, Boris B., Findling, Robert L., Horwitz, Sarah, Black, Sarah R.
Source: Journal of Child Psychology & Psychiatry. Feb2020, Vol. 61 Issue 2, p175-181. 7p. 1 Chart, 3 Graphs.
Subjects: Analysis of variance, Attention-deficit hyperactivity disorder, Chi-squared test, Bipolar disorder, Regression analysis, Comorbidity, Descriptive statistics, Disease complications, Disease risk factors, Adolescence, Children
Abstract: Objective: To examine development of bipolar spectrum disorders (BPSD) and other disorders in prospectively followed children with attention‐deficit/hyperactivity disorder (ADHD). Method: In the Longitudinal Assessment of Manic Symptoms (LAMS) study, 531 of 685 children age 6–12 (most selected for scores > 12 on General Behavior Inventory 10‐item Mania scale) had ADHD, 112 with BPSD, and 419 without. With annual assessments for 8 years, retention averaged 6.2 years. Chi‐square analyses compared rate of new BPSD and other comorbidity between those with versus without baseline ADHD and between retained versus resolved ADHD diagnosis. Cox regression tested factors influencing speed of BPSD onset. Results: Of 419 with baseline ADHD but not BPSD, 52 (12.4%) developed BPSD, compared with 16 of 110 (14.5%) without either baseline diagnosis. Those who developed BPSD had more nonmood comorbidity over the follow‐up than those who did not develop BPSD (p =.0001). Of 170 who still had ADHD at eight‐year follow‐up (and not baseline BPSD), 26 (15.3%) had developed BPSD, compared with 16 of 186 (8.6%) who had ADHD without BPSD at baseline but lost the ADHD diagnosis (χ2 = 3.82, p =.051). There was no statistical difference in whether ADHD persisted or not across new BPSD subtypes (χ2 = 1.62, p =.446). Of those who developed BPSD, speed of onset was not significantly related to baseline ADHD (p =.566), baseline anxiety (p =.121), baseline depression (p =.185), baseline disruptive behavior disorder (p =.184), age (B = −.11 p =.092), maternal mania (p =.389), or paternal mania (B =.73, p =.056). Those who started with both diagnoses had more severe symptoms/impairment than those with later developed BPSD and reported having ADHD first. Conclusions: In a cohort selected for symptoms of mania at age 6–12, baseline ADHD was not a significant prospective risk factor for developing BPSD. However, persistence of ADHD may marginally mediate risk of BPSD, and early comorbidity of both diagnoses increases severity/impairment. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Development of bipolar disorder and other comorbidity among youth with attention‐deficit/hyperactivity disorder.
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  Data: <searchLink fieldCode="AR" term="%22Arnold%2C+L%2E+Eugene%22">Arnold, L. Eugene</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Meter%2C+Anna+R%2E%22">Van Meter, Anna R.</searchLink><br /><searchLink fieldCode="AR" term="%22Fristad%2C+Mary+A%2E%22">Fristad, Mary A.</searchLink><br /><searchLink fieldCode="AR" term="%22Youngstrom%2C+Eric+A%2E%22">Youngstrom, Eric A.</searchLink><br /><searchLink fieldCode="AR" term="%22Birmaher%2C+Boris+B%2E%22">Birmaher, Boris B.</searchLink><br /><searchLink fieldCode="AR" term="%22Findling%2C+Robert+L%2E%22">Findling, Robert L.</searchLink><br /><searchLink fieldCode="AR" term="%22Horwitz%2C+Sarah%22">Horwitz, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Black%2C+Sarah+R%2E%22">Black, Sarah R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Feb2020, Vol. 61 Issue 2, p175-181. 7p. 1 Chart, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: To examine development of bipolar spectrum disorders (BPSD) and other disorders in prospectively followed children with attention‐deficit/hyperactivity disorder (ADHD). Method: In the Longitudinal Assessment of Manic Symptoms (LAMS) study, 531 of 685 children age 6–12 (most selected for scores > 12 on General Behavior Inventory 10‐item Mania scale) had ADHD, 112 with BPSD, and 419 without. With annual assessments for 8 years, retention averaged 6.2 years. Chi‐square analyses compared rate of new BPSD and other comorbidity between those with versus without baseline ADHD and between retained versus resolved ADHD diagnosis. Cox regression tested factors influencing speed of BPSD onset. Results: Of 419 with baseline ADHD but not BPSD, 52 (12.4%) developed BPSD, compared with 16 of 110 (14.5%) without either baseline diagnosis. Those who developed BPSD had more nonmood comorbidity over the follow‐up than those who did not develop BPSD (p =.0001). Of 170 who still had ADHD at eight‐year follow‐up (and not baseline BPSD), 26 (15.3%) had developed BPSD, compared with 16 of 186 (8.6%) who had ADHD without BPSD at baseline but lost the ADHD diagnosis (χ2 = 3.82, p =.051). There was no statistical difference in whether ADHD persisted or not across new BPSD subtypes (χ2 = 1.62, p =.446). Of those who developed BPSD, speed of onset was not significantly related to baseline ADHD (p =.566), baseline anxiety (p =.121), baseline depression (p =.185), baseline disruptive behavior disorder (p =.184), age (B = −.11 p =.092), maternal mania (p =.389), or paternal mania (B =.73, p =.056). Those who started with both diagnoses had more severe symptoms/impairment than those with later developed BPSD and reported having ADHD first. Conclusions: In a cohort selected for symptoms of mania at age 6–12, baseline ADHD was not a significant prospective risk factor for developing BPSD. However, persistence of ADHD may marginally mediate risk of BPSD, and early comorbidity of both diagnoses increases severity/impairment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.13122
    Languages:
      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 175
    Subjects:
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Bipolar disorder
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      – SubjectFull: Regression analysis
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      – SubjectFull: Comorbidity
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Disease complications
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      – SubjectFull: Disease risk factors
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      – SubjectFull: Adolescence
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      – SubjectFull: Children
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      – TitleFull: Development of bipolar disorder and other comorbidity among youth with attention‐deficit/hyperactivity disorder.
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              Text: Feb2020
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              Y: 2020
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