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GABAergic phenotypic differentiation of a subpopulation of subventricular derived migrating progenitors.

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Title: GABAergic phenotypic differentiation of a subpopulation of subventricular derived migrating progenitors.
Authors: De Marchis, S. (AUTHOR), Temoney, S. (AUTHOR), Erdelyi, F. (AUTHOR), Bovetti, S. (AUTHOR), Bovolin, P. (AUTHOR), Szabo, G. (AUTHOR), Puche, A. C. (AUTHOR)
Source: European Journal of Neuroscience. Sep2004, Vol. 20 Issue 5, p1307-1317. 11p.
Subjects: GABA, Phenotypes, Lineage, Olfactory cortex, Stem cells, Interneurons
Abstract: Olfactory bulb interneurons are continuously generated throughout development and in adulthood. These neurons are born in the subventricular zone (SVZ) and migrate along the rostral migratory stream into the olfactory bulb where they differentiate into local interneurons. To investigate the differentiation of GABAergic interneurons of the olfactory bulb we used a transgenic mouse which expresses green fluorescent protein (GFP) under the control of the glutamic acid decarboxylase 65 kDa (GAD65) promoter. During development and in adulthood GFP was expressed by cells in the SVZ and along the entire length of its rostra! extension including the distal portion within the olfactory bulb. The occurrence of GAD65 mRNA in these zones was confirmed by PCR analysis on microdissected regions along the pathway. Polysialic acid neural cell adhesion molecule, a marker of migrating neuroblasts in adults, was coexpressed by the majority of the GFP-positive SVZ-derived progenitor cells. Cell tracer injections into the SVZ indicated that ≈26% of migrating progenitor cells expressed GFP. These data show the early differentiation of migrating SVZ-derived progenitors into a GAD65-GFP-positive phenotype. These cells could represent a restricted lineage giving rise to GAD65-positive GABAergic olfactory bulb interneurons. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: GABAergic phenotypic differentiation of a subpopulation of subventricular derived migrating progenitors.
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  Data: <searchLink fieldCode="AR" term="%22De+Marchis%2C+S%2E%22">De Marchis, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Temoney%2C+S%2E%22">Temoney, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erdelyi%2C+F%2E%22">Erdelyi, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bovetti%2C+S%2E%22">Bovetti, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bovolin%2C+P%2E%22">Bovolin, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Szabo%2C+G%2E%22">Szabo, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Puche%2C+A%2E+C%2E%22">Puche, A. C.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2004, Vol. 20 Issue 5, p1307-1317. 11p.
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  Data: <searchLink fieldCode="DE" term="%22GABA%22">GABA</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Lineage%22">Lineage</searchLink><br /><searchLink fieldCode="DE" term="%22Olfactory+cortex%22">Olfactory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Interneurons%22">Interneurons</searchLink>
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  Label: Abstract
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  Data: Olfactory bulb interneurons are continuously generated throughout development and in adulthood. These neurons are born in the subventricular zone (SVZ) and migrate along the rostral migratory stream into the olfactory bulb where they differentiate into local interneurons. To investigate the differentiation of GABAergic interneurons of the olfactory bulb we used a transgenic mouse which expresses green fluorescent protein (GFP) under the control of the glutamic acid decarboxylase 65 kDa (GAD65) promoter. During development and in adulthood GFP was expressed by cells in the SVZ and along the entire length of its rostra! extension including the distal portion within the olfactory bulb. The occurrence of GAD65 mRNA in these zones was confirmed by PCR analysis on microdissected regions along the pathway. Polysialic acid neural cell adhesion molecule, a marker of migrating neuroblasts in adults, was coexpressed by the majority of the GFP-positive SVZ-derived progenitor cells. Cell tracer injections into the SVZ indicated that ≈26% of migrating progenitor cells expressed GFP. These data show the early differentiation of migrating SVZ-derived progenitors into a GAD65-GFP-positive phenotype. These cells could represent a restricted lineage giving rise to GAD65-positive GABAergic olfactory bulb interneurons. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Type: general
      – SubjectFull: Phenotypes
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              Text: Sep2004
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