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Eye movement abnormalities are associated with brainstem atrophy in Wilson disease.

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Title: Eye movement abnormalities are associated with brainstem atrophy in Wilson disease.
Authors: Hanuška, Jaromír (AUTHOR), Dušek, Petr (AUTHOR), Rusz, Jan (AUTHOR), Ulmanová, Olga (AUTHOR), Burgetová, Andrea (AUTHOR), Růžička, Evžen (AUTHOR)
Source: Neurological Sciences. May2020, Vol. 41 Issue 5, p1097-1103. 7p. 1 Black and White Photograph, 1 Chart, 3 Graphs.
Subjects: Eye movements, Hepatolenticular degeneration, Atrophy, Error rates, Mesencephalon, Saccadic eye movements, Eye movement disorders, Magnetic resonance imaging, Eye movement measurements, Research funding, Brain stem, Disease complications
Abstract: Backgrounds: This study aims to characterize eye movement abnormalities in Wilson disease and examine their association with the degree of brainstem atrophy.Methods: Twenty patients (10 males, mean age 46.8, SD 8.9 years) with genetically confirmed neurological WD on stable anti-copper treatment and 20 age- and sex-matched healthy subjects were examined. Eye movements, including prosaccade and antisaccade tasks, were evaluated using infrared videooculography. MRI was performed using 1.5 T system, and T2-weighted images were used for the measurement of midbrain and pontine area on mid-sagittal slices. Clinical severity was assessed using the Unified Wilson's Disease Rating Scale (UWDRS).Results: Compared to healthy controls, WD patients showed prolonged latencies of horizontal prosaccades and hypometry of both horizontal (p = 0.04) and vertical (p = 0.0046) prosaccades. In the antisaccade task, WD patients showed prolonged latency of both horizontal (p = 0.04) and vertical antisaccades (p = 0.047) and increased error rate of vertical antisaccades (p = 0.04). There is a significant association between midbrain area and horizontal latencies (r = -0.53; p = 0.02) and vertical maximum speed in prosaccades (r = 0.47; p = 0.04). The pons area inversely correlated with horizontal prosaccade and antisaccade latencies (p = 0.007).Conclusions: We showed impairments of ocular saccades such as prolonged latencies, hypometry, and increased error rate in antisaccades. The strong association between prolonged latencies of prosaccades and the brainstem atrophy suggests that VOG might serve as a sensitive electrophysiological marker of brainstem dysfunction in WD. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Eye movement abnormalities are associated with brainstem atrophy in Wilson disease.
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  Data: <searchLink fieldCode="AR" term="%22Hanuška%2C+Jaromír%22">Hanuška, Jaromír</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dušek%2C+Petr%22">Dušek, Petr</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rusz%2C+Jan%22">Rusz, Jan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ulmanová%2C+Olga%22">Ulmanová, Olga</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burgetová%2C+Andrea%22">Burgetová, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Růžička%2C+Evžen%22">Růžička, Evžen</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2020, Vol. 41 Issue 5, p1097-1103. 7p. 1 Black and White Photograph, 1 Chart, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Eye+movements%22">Eye movements</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatolenticular+degeneration%22">Hepatolenticular degeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Atrophy%22">Atrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Error+rates%22">Error rates</searchLink><br /><searchLink fieldCode="DE" term="%22Mesencephalon%22">Mesencephalon</searchLink><br /><searchLink fieldCode="DE" term="%22Saccadic+eye+movements%22">Saccadic eye movements</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+movement+disorders%22">Eye movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+movement+measurements%22">Eye movement measurements</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Backgrounds: </bold>This study aims to characterize eye movement abnormalities in Wilson disease and examine their association with the degree of brainstem atrophy.<bold>Methods: </bold>Twenty patients (10 males, mean age 46.8, SD 8.9 years) with genetically confirmed neurological WD on stable anti-copper treatment and 20 age- and sex-matched healthy subjects were examined. Eye movements, including prosaccade and antisaccade tasks, were evaluated using infrared videooculography. MRI was performed using 1.5 T system, and T2-weighted images were used for the measurement of midbrain and pontine area on mid-sagittal slices. Clinical severity was assessed using the Unified Wilson's Disease Rating Scale (UWDRS).<bold>Results: </bold>Compared to healthy controls, WD patients showed prolonged latencies of horizontal prosaccades and hypometry of both horizontal (p = 0.04) and vertical (p = 0.0046) prosaccades. In the antisaccade task, WD patients showed prolonged latency of both horizontal (p = 0.04) and vertical antisaccades (p = 0.047) and increased error rate of vertical antisaccades (p = 0.04). There is a significant association between midbrain area and horizontal latencies (r = -0.53; p = 0.02) and vertical maximum speed in prosaccades (r = 0.47; p = 0.04). The pons area inversely correlated with horizontal prosaccade and antisaccade latencies (p = 0.007).<bold>Conclusions: </bold>We showed impairments of ocular saccades such as prolonged latencies, hypometry, and increased error rate in antisaccades. The strong association between prolonged latencies of prosaccades and the brainstem atrophy suggests that VOG might serve as a sensitive electrophysiological marker of brainstem dysfunction in WD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-019-04225-3
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        Text: English
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        PageCount: 7
        StartPage: 1097
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      – SubjectFull: Eye movements
        Type: general
      – SubjectFull: Hepatolenticular degeneration
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      – SubjectFull: Atrophy
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      – SubjectFull: Error rates
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      – SubjectFull: Mesencephalon
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      – SubjectFull: Brain stem
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      – TitleFull: Eye movement abnormalities are associated with brainstem atrophy in Wilson disease.
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              Text: May2020
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