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Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first‐episode psychosis cohort.

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Title: Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first‐episode psychosis cohort.
Authors: Mas, S. (AUTHOR), Gassó, P. (AUTHOR), Rodríguez, N. (AUTHOR), Cabrera, B. (AUTHOR), Mezquida, G. (AUTHOR), Lobo, A. (AUTHOR), González‐Pinto, A. (AUTHOR), Parellada, M. (AUTHOR), Corripio, I. (AUTHOR), Vieta, E. (AUTHOR), Castro‐Fornieles, J. (AUTHOR), Bobes, J. (AUTHOR), Usall, J. (AUTHOR), Saiz‐Ruiz, J. (AUTHOR), Contreras, F. (AUTHOR), Parellada, E. (AUTHOR), Bernardo, M. (AUTHOR), Lafuente, Amalia (AUTHOR), Bioque, Miquel (AUTHOR), Diaz‐Caneja, Covadonga M. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Jun2020, Vol. 141 Issue 6, p541-552. 12p. 2 Charts, 2 Graphs.
Subjects: Individualized medicine, Psychoses, Phenotypes, Age of onset, Mental illness
Abstract: Aims: Here, we present a clustering strategy to identify phenotypes of antipsychotic (AP) response by using longitudinal data from patients presenting first‐episode psychosis (FEP). Method: One hundred and ninety FEP with complete data were selected from the PEPs project. The efficacy was assessed using total PANSS, and adverse effects using total UKU, during one‐year follow‐up. We used the Klm3D method to cluster longitudinal data. Results: We identified four clusters: cluster A, drug not toxic and beneficial; cluster B, drug beneficial but toxic; cluster C, drug neither toxic nor beneficial; and cluster D, drug toxic and not beneficial. These groups significantly differ in baseline demographics, clinical, and neuropsychological characteristics (PAS, total PANSS, DUP, insight, pIQ, age of onset, cocaine use and family history of mental illness). Conclusions: The results presented here allow the identification of phenotypes of AP response that differ in well‐known simple and classic clinical variables opening the door to clinical prediction and application of personalized medicine. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first‐episode psychosis cohort.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jun2020, Vol. 141 Issue 6, p541-552. 12p. 2 Charts, 2 Graphs.
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  Data: Aims: Here, we present a clustering strategy to identify phenotypes of antipsychotic (AP) response by using longitudinal data from patients presenting first‐episode psychosis (FEP). Method: One hundred and ninety FEP with complete data were selected from the PEPs project. The efficacy was assessed using total PANSS, and adverse effects using total UKU, during one‐year follow‐up. We used the Klm3D method to cluster longitudinal data. Results: We identified four clusters: cluster A, drug not toxic and beneficial; cluster B, drug beneficial but toxic; cluster C, drug neither toxic nor beneficial; and cluster D, drug toxic and not beneficial. These groups significantly differ in baseline demographics, clinical, and neuropsychological characteristics (PAS, total PANSS, DUP, insight, pIQ, age of onset, cocaine use and family history of mental illness). Conclusions: The results presented here allow the identification of phenotypes of AP response that differ in well‐known simple and classic clinical variables opening the door to clinical prediction and application of personalized medicine. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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