View in EDS HTML Full Text PDF Full Text

Can network analysis shed light on predictors of lithium response in bipolar I disorder?

Saved in:
Bibliographic Details
Title: Can network analysis shed light on predictors of lithium response in bipolar I disorder?
Authors: Scott, J. (AUTHOR), Bellivier, F. (AUTHOR), Manchia, M. (AUTHOR), Schulze, T. (AUTHOR), Alda, M. (AUTHOR), Etain, B. (AUTHOR), Cervantes, Pablo (AUTHOR), Garnham, Julie (AUTHOR), Nunes, Abraham (AUTHOR), O'Donovan, Claire (AUTHOR), Slaney, Claire (AUTHOR), Bauer, Michael (AUTHOR), Pfennig, Andrea (AUTHOR), Reif, Andreas (AUTHOR), Kittel‐Schneider, Sarah (AUTHOR), Veeh, Julia (AUTHOR), Zompo, Maria del (AUTHOR), Ardau, Raffaella (AUTHOR), Chillotti, Caterina (AUTHOR), Severino, Giovanni (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Jun2020, Vol. 141 Issue 6, p522-533. 12p. 1 Illustration, 1 Diagram, 2 Charts, 1 Graph.
Subjects: Bipolar disorder, Therapeutic use of lithium, Obsessive-compulsive disorder, Panic disorders, Anxiety disorders
Abstract: Objective: To undertake a large‐scale clinical study of predictors of lithium (Li) response in bipolar I disorder (BD‐I) and apply contemporary multivariate approaches to account for inter‐relationships between putative predictors. Methods: We used network analysis to estimate the number and strength of connections between potential predictors of good Li response (measured by a new scoring algorithm for the Retrospective Assessment of Response to Lithium Scale) in 900 individuals with BD‐I recruited to the Consortium of Lithium Genetics. Results: After accounting for co‐associations between potential predictors, the most important factors associated with the good Li response phenotype were panic disorder, manic predominant polarity, manic first episode, age at onset between 15–32 years and family history of BD. Factors most strongly linked to poor outcome were comorbid obsessive–compulsive disorder, alcohol and/or substance misuse, and/or psychosis (symptoms or syndromes). Conclusions: Network analysis can offer important additional insights to prospective studies of predictors of Li treatment outcomes. It appears to especially help in further clarifying the role of family history of BD (i.e. its direct and indirect associations) and highlighting the positive and negative associations of different subtypes of anxiety disorders with Li response, particularly the little‐known negative association between Li response and obsessive–compulsive disorder. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 143634110
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Can network analysis shed light on predictors of lithium response in bipolar I disorder?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Scott%2C+J%2E%22">Scott, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bellivier%2C+F%2E%22">Bellivier, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manchia%2C+M%2E%22">Manchia, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulze%2C+T%2E%22">Schulze, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alda%2C+M%2E%22">Alda, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Etain%2C+B%2E%22">Etain, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cervantes%2C+Pablo%22">Cervantes, Pablo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garnham%2C+Julie%22">Garnham, Julie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nunes%2C+Abraham%22">Nunes, Abraham</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22O'Donovan%2C+Claire%22">O'Donovan, Claire</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Slaney%2C+Claire%22">Slaney, Claire</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bauer%2C+Michael%22">Bauer, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pfennig%2C+Andrea%22">Pfennig, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reif%2C+Andreas%22">Reif, Andreas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kittel‐Schneider%2C+Sarah%22">Kittel‐Schneider, Sarah</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Veeh%2C+Julia%22">Veeh, Julia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zompo%2C+Maria+del%22">Zompo, Maria del</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ardau%2C+Raffaella%22">Ardau, Raffaella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chillotti%2C+Caterina%22">Chillotti, Caterina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Severino%2C+Giovanni%22">Severino, Giovanni</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jun2020, Vol. 141 Issue 6, p522-533. 12p. 1 Illustration, 1 Diagram, 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+lithium%22">Therapeutic use of lithium</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Panic+disorders%22">Panic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To undertake a large‐scale clinical study of predictors of lithium (Li) response in bipolar I disorder (BD‐I) and apply contemporary multivariate approaches to account for inter‐relationships between putative predictors. Methods: We used network analysis to estimate the number and strength of connections between potential predictors of good Li response (measured by a new scoring algorithm for the Retrospective Assessment of Response to Lithium Scale) in 900 individuals with BD‐I recruited to the Consortium of Lithium Genetics. Results: After accounting for co‐associations between potential predictors, the most important factors associated with the good Li response phenotype were panic disorder, manic predominant polarity, manic first episode, age at onset between 15–32 years and family history of BD. Factors most strongly linked to poor outcome were comorbid obsessive–compulsive disorder, alcohol and/or substance misuse, and/or psychosis (symptoms or syndromes). Conclusions: Network analysis can offer important additional insights to prospective studies of predictors of Li treatment outcomes. It appears to especially help in further clarifying the role of family history of BD (i.e. its direct and indirect associations) and highlighting the positive and negative associations of different subtypes of anxiety disorders with Li response, particularly the little‐known negative association between Li response and obsessive–compulsive disorder. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=143634110
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/acps.13163
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 522
    Subjects:
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Therapeutic use of lithium
        Type: general
      – SubjectFull: Obsessive-compulsive disorder
        Type: general
      – SubjectFull: Panic disorders
        Type: general
      – SubjectFull: Anxiety disorders
        Type: general
    Titles:
      – TitleFull: Can network analysis shed light on predictors of lithium response in bipolar I disorder?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Scott, J.
      – PersonEntity:
          Name:
            NameFull: Bellivier, F.
      – PersonEntity:
          Name:
            NameFull: Manchia, M.
      – PersonEntity:
          Name:
            NameFull: Schulze, T.
      – PersonEntity:
          Name:
            NameFull: Alda, M.
      – PersonEntity:
          Name:
            NameFull: Etain, B.
      – PersonEntity:
          Name:
            NameFull: Cervantes, Pablo
      – PersonEntity:
          Name:
            NameFull: Garnham, Julie
      – PersonEntity:
          Name:
            NameFull: Nunes, Abraham
      – PersonEntity:
          Name:
            NameFull: O'Donovan, Claire
      – PersonEntity:
          Name:
            NameFull: Slaney, Claire
      – PersonEntity:
          Name:
            NameFull: Bauer, Michael
      – PersonEntity:
          Name:
            NameFull: Pfennig, Andrea
      – PersonEntity:
          Name:
            NameFull: Reif, Andreas
      – PersonEntity:
          Name:
            NameFull: Kittel‐Schneider, Sarah
      – PersonEntity:
          Name:
            NameFull: Veeh, Julia
      – PersonEntity:
          Name:
            NameFull: Zompo, Maria del
      – PersonEntity:
          Name:
            NameFull: Ardau, Raffaella
      – PersonEntity:
          Name:
            NameFull: Chillotti, Caterina
      – PersonEntity:
          Name:
            NameFull: Severino, Giovanni
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 0001690X
          Numbering:
            – Type: volume
              Value: 141
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Acta Psychiatrica Scandinavica
              Type: main
ResultId 1