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Advanced cancer patient preferences for receiving molecular profiling results.

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Title: Advanced cancer patient preferences for receiving molecular profiling results.
Authors: Best, Megan (AUTHOR), Butow, Phyllis (AUTHOR), Jacobs, Chris (AUTHOR), Juraskova, Ilona (AUTHOR), Savard, Jacqueline (AUTHOR), Meiser, Bettina (AUTHOR), Goldstein, David (AUTHOR), Ballinger, Mandy (AUTHOR), Bartley, Nicci (AUTHOR), Napier, Christine (AUTHOR), Davies, Grace (AUTHOR), Thomas, David (AUTHOR), Tucker, Kathy (AUTHOR), Schlub, Timothy (AUTHOR), Newson, Ainsley J. (AUTHOR), And Members of the PiGeOn Project (CORPORATE AUTHOR), PiGeOn Project (CORPORATE AUTHOR)
Source: Psycho-Oncology. Oct2020, Vol. 29 Issue 10, p1533-1539. 7p. 2 Charts.
Subjects: Medical personnel, Cancer patients, Freedom of information, Cancer treatment, Attitude (Psychology)
Abstract: Objective: This study aimed to discern preferences for receiving somatic molecular profiling (MP) results in cancer patients who have given consent to undergo testing.Methods: We conducted a mixed-methods study to explore patients' views on which MP results they would like to receive and why. Advanced cancer patients (n = 1299) completed questionnaires after giving consent to participate in a parent genomics study and undergoing MP. A subset of patients (n = 20) participated in qualitative interviews.Results: Almost all (96%) participants were interested in receiving results which would direct cancer treatment (ie, were actionable). A smaller majority wanted to access results which were not actionable (64%) or were variants of unknown significance (60%). Most (86%) were interested in finding out about germline findings, though not as a priority. Themes identified in interview data were: (a) Cancer is the focus; (b) Trust in clinicians; and (c) Respect for a right not to know.Conclusions: The majority of advanced cancer patients undergoing MP prioritised results which would lead to treatment options. They trusted their oncologists to help them navigate the results return process. While there was interest in knowing about other results, this was a lesser priority. Nevertheless, given high levels of interest in receiving all results, ethical aspects of not providing uninformative results requires further research, including a consideration of patient rationales for desiring this information and what health professionals can and should do to support patients in the absence of meaningful information being available. [ABSTRACT FROM AUTHOR]
Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Advanced cancer patient preferences for receiving molecular profiling results.
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  Data: <searchLink fieldCode="AR" term="%22Best%2C+Megan%22">Best, Megan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Butow%2C+Phyllis%22">Butow, Phyllis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jacobs%2C+Chris%22">Jacobs, Chris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Juraskova%2C+Ilona%22">Juraskova, Ilona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Savard%2C+Jacqueline%22">Savard, Jacqueline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meiser%2C+Bettina%22">Meiser, Bettina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goldstein%2C+David%22">Goldstein, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ballinger%2C+Mandy%22">Ballinger, Mandy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bartley%2C+Nicci%22">Bartley, Nicci</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Napier%2C+Christine%22">Napier, Christine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davies%2C+Grace%22">Davies, Grace</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomas%2C+David%22">Thomas, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tucker%2C+Kathy%22">Tucker, Kathy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schlub%2C+Timothy%22">Schlub, Timothy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Newson%2C+Ainsley+J%2E%22">Newson, Ainsley J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22And+Members+of+the+PiGeOn+Project%22">And Members of the PiGeOn Project</searchLink> (CORPORATE AUTHOR)<br /><searchLink fieldCode="AR" term="%22PiGeOn+Project%22">PiGeOn Project</searchLink> (CORPORATE AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Medical+personnel%22">Medical personnel</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Freedom+of+information%22">Freedom of information</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Attitude+%28Psychology%29%22">Attitude (Psychology)</searchLink>
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  Data: <bold>Objective: </bold>This study aimed to discern preferences for receiving somatic molecular profiling (MP) results in cancer patients who have given consent to undergo testing.<bold>Methods: </bold>We conducted a mixed-methods study to explore patients' views on which MP results they would like to receive and why. Advanced cancer patients (n = 1299) completed questionnaires after giving consent to participate in a parent genomics study and undergoing MP. A subset of patients (n = 20) participated in qualitative interviews.<bold>Results: </bold>Almost all (96%) participants were interested in receiving results which would direct cancer treatment (ie, were actionable). A smaller majority wanted to access results which were not actionable (64%) or were variants of unknown significance (60%). Most (86%) were interested in finding out about germline findings, though not as a priority. Themes identified in interview data were: (a) Cancer is the focus; (b) Trust in clinicians; and (c) Respect for a right not to know.<bold>Conclusions: </bold>The majority of advanced cancer patients undergoing MP prioritised results which would lead to treatment options. They trusted their oncologists to help them navigate the results return process. While there was interest in knowing about other results, this was a lesser priority. Nevertheless, given high levels of interest in receiving all results, ethical aspects of not providing uninformative results requires further research, including a consideration of patient rationales for desiring this information and what health professionals can and should do to support patients in the absence of meaningful information being available. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/pon.5446
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