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HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome.

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Title: HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome.
Authors: Gigli, Gian Luigi (AUTHOR), Vogrig, Alberto (AUTHOR), Nilo, Annacarmen (AUTHOR), Fabris, Martina (AUTHOR), Biasotto, Alessia (AUTHOR), Curcio, Francesco (AUTHOR), Miotti, Valeria (AUTHOR), Tascini, Carlo (AUTHOR), Valente, Mariarosaria (AUTHOR)
Source: Neurological Sciences. Dec2020, Vol. 41 Issue 12, p3391-3394. 4p. 2 Charts.
Subjects: Guillain-Barré syndrome, COVID-19, SARS-CoV-2, Interleukin-6, Classical swine fever, Alleles
Abstract: We report the clinical and immunological features in a case of SARS-CoV-2-induced Guillain-Barré syndrome (Si-GBS), suggesting that (1) Si-GBS can develop even after paucisymptomatic COVID-19 infection; (2) a distinctive cytokine repertoire is associated with this autoimmune complication, with increased CSF concentration of IL-8, and moderately increased serum levels of IL-6, IL-8, and TNF-α; (3) a particular genetic predisposition can be relevant, since the patient carried several HLA alleles known to be associated with GBS, including distinctive class I (HLA-A33) and class II alleles (DRB1*03:01 and DQB1*05:01). To the best of our knowledge, this is the first case of GBS in which SARS-CoV-2 antibodies were detected in the CSF, further strengthening the role of the virus as a trigger. In conclusion, our study suggests that SARS-CoV-2 antibodies need to be searched in the serum and CSF in patients with GBS living in endemic areas, even in the absence of a clinically severe COVID-19 infection, and that IL-8 pathway can be relevant in Si-GBS pathogenesis. Further studies are needed to conclude on the relevance of the genetic findings, but it is likely that HLA plays a role in this setting as in other autoimmune neurological syndromes, including those triggered by infections. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome.
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  Data: <searchLink fieldCode="AR" term="%22Gigli%2C+Gian+Luigi%22">Gigli, Gian Luigi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vogrig%2C+Alberto%22">Vogrig, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nilo%2C+Annacarmen%22">Nilo, Annacarmen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fabris%2C+Martina%22">Fabris, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Biasotto%2C+Alessia%22">Biasotto, Alessia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Curcio%2C+Francesco%22">Curcio, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miotti%2C+Valeria%22">Miotti, Valeria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tascini%2C+Carlo%22">Tascini, Carlo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valente%2C+Mariarosaria%22">Valente, Mariarosaria</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2020, Vol. 41 Issue 12, p3391-3394. 4p. 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Guillain-Barré+syndrome%22">Guillain-Barré syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22Classical+swine+fever%22">Classical swine fever</searchLink><br /><searchLink fieldCode="DE" term="%22Alleles%22">Alleles</searchLink>
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  Label: Abstract
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  Data: We report the clinical and immunological features in a case of SARS-CoV-2-induced Guillain-Barré syndrome (Si-GBS), suggesting that (1) Si-GBS can develop even after paucisymptomatic COVID-19 infection; (2) a distinctive cytokine repertoire is associated with this autoimmune complication, with increased CSF concentration of IL-8, and moderately increased serum levels of IL-6, IL-8, and TNF-α; (3) a particular genetic predisposition can be relevant, since the patient carried several HLA alleles known to be associated with GBS, including distinctive class I (HLA-A33) and class II alleles (DRB1*03:01 and DQB1*05:01). To the best of our knowledge, this is the first case of GBS in which SARS-CoV-2 antibodies were detected in the CSF, further strengthening the role of the virus as a trigger. In conclusion, our study suggests that SARS-CoV-2 antibodies need to be searched in the serum and CSF in patients with GBS living in endemic areas, even in the absence of a clinically severe COVID-19 infection, and that IL-8 pathway can be relevant in Si-GBS pathogenesis. Further studies are needed to conclude on the relevance of the genetic findings, but it is likely that HLA plays a role in this setting as in other autoimmune neurological syndromes, including those triggered by infections. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Dec2020
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