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Detection of disability worsening in relapsing‐remitting multiple sclerosis patients: a real‐world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register.

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Title: Detection of disability worsening in relapsing‐remitting multiple sclerosis patients: a real‐world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register.
Authors: Lepore, V. (AUTHOR), Bosetti, C. (AUTHOR), Santucci, C. (AUTHOR), Iaffaldano, P. (AUTHOR), Trojano, M. (AUTHOR), Mosconi, P. (AUTHOR), Totaro, Rocco (AUTHOR), Coniglio, Maria Gabriella (AUTHOR), Bossio, Roberto Bruno (AUTHOR), Valentino, Paola (AUTHOR), Gatto, Maurizia (AUTHOR), Paolicelli, Damiano (AUTHOR), Ardito, Bonaventura (AUTHOR), Barcella, Valeria (AUTHOR), Capone, Lorenzo (AUTHOR), Nicolao, Piero (AUTHOR), Lugaresi, Alessandra (AUTHOR), Rini, Augusto (AUTHOR), Bianchi, Marta (AUTHOR), Plasmati, Imma (AUTHOR)
Source: European Journal of Neurology. Feb2021, Vol. 28 Issue 2, p567-578. 12p.
Subjects: Multiple sclerosis, Disabilities, Disease relapse
Abstract: Background and purpose: In relapsing‐remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6‐month confirmed disability‐worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real‐world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability‐worsening events and of confirmed disability‐worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6‐year overall confirmed disability‐worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability‐worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability‐worsening events). Conclusions: In a real‐world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability‐worsening events unrelated to relapse in RRMS patients. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Detection of disability worsening in relapsing‐remitting multiple sclerosis patients: a real‐world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Lepore%2C+V%2E%22">Lepore, V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bosetti%2C+C%2E%22">Bosetti, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Santucci%2C+C%2E%22">Santucci, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iaffaldano%2C+P%2E%22">Iaffaldano, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Trojano%2C+M%2E%22">Trojano, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mosconi%2C+P%2E%22">Mosconi, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Totaro%2C+Rocco%22">Totaro, Rocco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coniglio%2C+Maria+Gabriella%22">Coniglio, Maria Gabriella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bossio%2C+Roberto+Bruno%22">Bossio, Roberto Bruno</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valentino%2C+Paola%22">Valentino, Paola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gatto%2C+Maurizia%22">Gatto, Maurizia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paolicelli%2C+Damiano%22">Paolicelli, Damiano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ardito%2C+Bonaventura%22">Ardito, Bonaventura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barcella%2C+Valeria%22">Barcella, Valeria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Capone%2C+Lorenzo%22">Capone, Lorenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nicolao%2C+Piero%22">Nicolao, Piero</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lugaresi%2C+Alessandra%22">Lugaresi, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rini%2C+Augusto%22">Rini, Augusto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bianchi%2C+Marta%22">Bianchi, Marta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plasmati%2C+Imma%22">Plasmati, Imma</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2021, Vol. 28 Issue 2, p567-578. 12p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Disabilities%22">Disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: In relapsing‐remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6‐month confirmed disability‐worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real‐world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability‐worsening events and of confirmed disability‐worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6‐year overall confirmed disability‐worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability‐worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability‐worsening events). Conclusions: In a real‐world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability‐worsening events unrelated to relapse in RRMS patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=148145027
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        Value: 10.1111/ene.14589
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        Text: English
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        PageCount: 12
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      – SubjectFull: Multiple sclerosis
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      – SubjectFull: Disabilities
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      – SubjectFull: Disease relapse
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