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Neurophysiological markers of response to theta burst stimulation in youth depression.

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Title: Neurophysiological markers of response to theta burst stimulation in youth depression.
Authors: Dhami, Prabhjot (AUTHOR), Atluri, Sravya (AUTHOR), Lee, Jonathan (AUTHOR), Knyahnytska, Yuliya (AUTHOR), Croarkin, Paul E. (AUTHOR), Blumberger, Daniel M. (AUTHOR), Daskalakis, Zafiris J. (AUTHOR), Farzan, Faranak (AUTHOR)
Source: Depression & Anxiety (1091-4269). Feb2021, Vol. 38 Issue 2, p172-184. 13p. 2 Color Photographs, 2 Charts, 1 Graph.
Subjects: Functional magnetic resonance imaging, Transcranial magnetic stimulation, Mental depression, Prefrontal cortex
Abstract: Background: Theta burst stimulation (TBS) has recently been proposed as a novel treatment for youth depression. However, the impact of TBS on the youth brain and neurophysiological predictors of response to TBS in this population have not been investigated. Methods: Cortical reactivity was assessed at baseline and following 2 weeks of bilateral dorsolateral prefrontal cortex (DLPFC) TBS treatment in 16 youth with depression (aged 16–24 years old). In 16 age‐matched health youths, cortical reactivity was assessed twice, 2 weeks apart. Transcranial magnetic stimulation (TMS) combined with electroencephalography was used to assess TMS‐evoked potentials in bilateral DLPFC, motor cortices, and intraparietal lobules (IPL). Resting‐state functional magnetic resonance imaging (fMRI) data was also collected at baseline. Results: Left DLPFC pretreatment cortical reactivity, specifically the negativity at 45 ms (i.e., N45), which is related to GABAA neurotransmission, was associated with changes in depressive symptoms. Furthermore, TBS treatment was found to alter the N45 in the right IPL, a site distal to the treatment sites. The magnitude of the right IPL N45 modulation was correlated with the baseline fMRI connectivity between the right IPL and right DLPFC. Conclusions: TMS‐probed cortical inhibition at the site of TBS application may have potential as a predictor of treatment response in youth depression. Furthermore, pre‐treatment functional connectivity may predict the impact of TBS on the neurophysiology of regions distal to the stimulation site. Collectively, these results offer novel neurophysiological insights into the application of TBS for youth depression, which may facilitate its wider use in the youth population. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Neurophysiological markers of response to theta burst stimulation in youth depression.
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  Data: <searchLink fieldCode="AR" term="%22Dhami%2C+Prabhjot%22">Dhami, Prabhjot</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Atluri%2C+Sravya%22">Atluri, Sravya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jonathan%22">Lee, Jonathan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Knyahnytska%2C+Yuliya%22">Knyahnytska, Yuliya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Croarkin%2C+Paul+E%2E%22">Croarkin, Paul E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blumberger%2C+Daniel+M%2E%22">Blumberger, Daniel M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Daskalakis%2C+Zafiris+J%2E%22">Daskalakis, Zafiris J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farzan%2C+Faranak%22">Farzan, Faranak</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Feb2021, Vol. 38 Issue 2, p172-184. 13p. 2 Color Photographs, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Transcranial+magnetic+stimulation%22">Transcranial magnetic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Theta burst stimulation (TBS) has recently been proposed as a novel treatment for youth depression. However, the impact of TBS on the youth brain and neurophysiological predictors of response to TBS in this population have not been investigated. Methods: Cortical reactivity was assessed at baseline and following 2 weeks of bilateral dorsolateral prefrontal cortex (DLPFC) TBS treatment in 16 youth with depression (aged 16–24 years old). In 16 age‐matched health youths, cortical reactivity was assessed twice, 2 weeks apart. Transcranial magnetic stimulation (TMS) combined with electroencephalography was used to assess TMS‐evoked potentials in bilateral DLPFC, motor cortices, and intraparietal lobules (IPL). Resting‐state functional magnetic resonance imaging (fMRI) data was also collected at baseline. Results: Left DLPFC pretreatment cortical reactivity, specifically the negativity at 45 ms (i.e., N45), which is related to GABAA neurotransmission, was associated with changes in depressive symptoms. Furthermore, TBS treatment was found to alter the N45 in the right IPL, a site distal to the treatment sites. The magnitude of the right IPL N45 modulation was correlated with the baseline fMRI connectivity between the right IPL and right DLPFC. Conclusions: TMS‐probed cortical inhibition at the site of TBS application may have potential as a predictor of treatment response in youth depression. Furthermore, pre‐treatment functional connectivity may predict the impact of TBS on the neurophysiology of regions distal to the stimulation site. Collectively, these results offer novel neurophysiological insights into the application of TBS for youth depression, which may facilitate its wider use in the youth population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Neurophysiological markers of response to theta burst stimulation in youth depression.
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              Text: Feb2021
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              Y: 2021
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